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Understanding the charismatic potential of nanotechnology to treat skin carcinoma

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Abstract

Carcinoma is a condition that continues to pose a significant challenge, despite current medical advances. Skin carcinoma is the leading cause of cancer, and it has seen a massive increase all over the world. The challenges with current treatment are due to toxicity that leads to many more skin complications. Due to this to avoid such complications by designing diverse nanoparticles as delivery carriers, nanomedicine is employed as a hub for diagnostics and therapy. Liposomes, gold nanoparticles, transferases, nanofibers, etc., can all be used as delivery nanocarriers. These nanoparticles’ structures and characteristics protect the medicine from degradation and improve its stability. Surface modifying agents and procedures are employed to functionalize nanoparticles, resulting in smart delivery systems. The application of nanotechnology-based approaches systematically increases drug delivery to target cells. Skin cancer has several challenges, including a long time to diagnose early types of cancer and a slower growth rate. This review focuses on innovative skin cancer therapy techniques, focusing on nanotechnology and the challenges associated with current treatment of skin cancer.

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Data availability

The authors confirm that the data supporting the findings of this study are available within the article references.

Abbreviations

AuNP:

Gold nanoparticle

BCC:

Basal cell carcinoma

CPD:

Cyclopyrimidine dimer

DAMPs:

Danger-associated molecular patterns

DNMTs:

DNA methyltransferases

HH:

Hedgehog pathway

MM:

Malignant melanoma

MC1R:

Melanocortin 1 receptor

NMSC:

Nonmelanoma skin cancer

PDT:

Photodynamic therapy

PTT:

Photothermal therapy

ROS:

Reactive oxygen species

SCC:

Squamous cell carcinoma

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Acknowledgements

The authors would like to acknowledge Dr. R.S. Gaud, Director, Pharma Section, SVKM’s NMIMS Deemed-to-be University, for providing excellent research facilities and deep encouragement whilst pursuing this project

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM’S NMIMS Deemed-to-be University, Shirpur, Maharashtra, 425405, India

    Aamravi Sathe & Sankha Bhattacharya

  2. Shree S K Patel College of Pharmaceutical Education and Research, Ganpat University, Mahesana, Gujarat, 384012, India

    Bhupendra G. Prajapati

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  1. Aamravi Sathe
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Contributions

AS: initiated and designed this study, contributed to data interpretation, and wrote the original manuscript. SB: collected the data, contributed to data interpretation, and drafted the manuscript and further supervised the study. All the authors have reviewed and approved the final manuscript.

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Correspondence to Sankha Bhattacharya.

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Sathe, A., Prajapati, B.G. & Bhattacharya, S. Understanding the charismatic potential of nanotechnology to treat skin carcinoma. Med Oncol 41, 22 (2024). https://doi.org/10.1007/s12032-023-02258-5

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