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Serum 25-hydroxyvitamin D status among Saudi children with and without a history of fracture

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Abstract

Background

The significance of vitamin D deficiency in the incidence of bone fractures in children has been under investigated. Here, we aimed to associate serum 25-hydroxyvitamin D levels and fractures in Saudi children.

Materials and methods

This cross-sectional study was conducted in 1022 Saudi children without fracture history [476 boys (age 14.56 ± 1.81, BMI 22.38 ± 5.81) and 546 girls (age 13.57 ± 1.67, BMI 22.24 ± 4.94)] and 234 Saudi children with a history of fracture [148 boys (age 14.25 ± 1.39, BMI 22.66 ± 6.08) and 86 girls (age 13.76 ± 1.35, BMI 21.33 ± 1.35)]. Anthropometric and fasting serum biochemical data were collected. Serum 25-hydroxyvitamin D level was assessed using electrochemiluminescence.

Results

Mean circulating 25-hydroxyvitamin (25OH) D level in subjects with a history of fracture was significantly lower in both boys (p < 0.01) and girls (p < 0.01) than those without, however both groups had low mean 25(OH)D levels. Furthermore, age was positively associated with 25-hydroxyvitamin D in boys (p < 0.05) and negatively in girls (p < 0.05) with a history of fracture.

Conclusion

In conclusion, vitamin D levels were significantly lower in children with a history of bone fractures in both boys and girls than those without such a history; even in the absence of fracture history, vitamin D status correction is warranted in the general Saudi pediatric population.

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Acknowledgments

The authors thank Mr. Malak Nawaz Khan Khattak and Mr. Danish Syed Hussain in the statistical analyses of the data.

Funding

This study was funded by the Deanship of Scientific Research at King Saud University, Riyadh, Saudi Arabia for its funding [Prolific Research Group Program (PRG-1436-15)].

Author information

Authors and Affiliations

  1. Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Al-Daghri, S. Rahman, S. Sabico, O. S. Al-Attas & M. S. Alokail

  2. Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Al-Daghri, N. Aljohani, S. Rahman, S. Sabico, O. S. Al-Attas & M. S. Alokail

  3. Obesity, Endocrine and Metabolism Center, King Fahad Medical City, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, 11461, Saudi Arabia

    N. Aljohani

  4. Department of Clinical Lab Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11433, Saudi Arabia

    A. Al-Ajlan

  5. First Department of Pediatrics, Athens University Medical School, 11527, Athens, Greece

    G. P. Chrousos

Authors
  1. N. M. Al-Daghri
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  2. N. Aljohani
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  3. S. Rahman
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  4. S. Sabico
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  5. O. S. Al-Attas
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  6. M. S. Alokail
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  7. A. Al-Ajlan
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  8. G. P. Chrousos
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Corresponding author

Correspondence to N. M. Al-Daghri.

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Author contributions

Nasser M. Al-Daghri conceptualized and designed the study, and approved the final manuscript as submitted. Shakilur Rahman and Shaun Sabico contributed in the preparation and revision of the manuscript, carried out the initial analyses, reviewed and revised the manuscript, and approved the final manuscript as submitted. Naji Aljohani, Abdulrahman Al-Ajlan, Omar Al-Attas, and Majed Alokail and George Chrousos edited, critically reviewed, and approved the final version of the manuscript as submitted.

Conflict of interest

None.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Written informed consent was obtained from parents, as well as a verbal assent for children, prior to inclusion in the study.

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Al-Daghri, N.M., Aljohani, N., Rahman, S. et al. Serum 25-hydroxyvitamin D status among Saudi children with and without a history of fracture. J Endocrinol Invest 39, 1125–1130 (2016). https://doi.org/10.1007/s40618-016-0496-7

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  • DOI: https://doi.org/10.1007/s40618-016-0496-7

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