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The effects of dementia on the prognosis and mortality of hip fracture surgery: a systematic review and meta-analysis

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Abstract

Objectives

Dementia is a common mental disorder that affects the life quality in elders. Recently, emerging studies reported the negative impacts of dementia on prognosis after hip surgeries. However, the integrated and reliable role of dementia in hip surgery is not illustrated.

Methods

We searched the relevant literatures before June 2020 and extracted the data that met the inclusion criteria. The influence of dementia on postoperative walking ability, complications including infection, cardiovascular complications, hip dislocation, delirium, and respiratory complications, and survival rate at different periods were evaluated. Qualitative and quantitative analysis were conducted using Review Manager Version 5.3.

Results

The meta-analysis enrolled a total of 30 studies with 1,037,049 patients. The pooled results revealed that there were significant negative impacts of dementia on the recovery of postoperative walking ability, postoperative infection, hip dislocation, delirium and respiratory complications and mortality at different periods.

Conclusions

Dementia is a crucial risk factor for the poor prognosis after hip fracture surgery. Therefore, when making clinical strategies for hip fracture patients with dementia, countermeasures for possible complications should be generated.

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Funding

This work was supported by the National Natural Science Foundation of China [31771063]; the Natural Science Foundation of Jiangsu Province [BK20191173]; and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

Author information

Author notes

  1. Mingzhuang Hou and Yijian Zhang contributed equally.

Authors and Affiliations

  1. Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China

    Mingzhuang Hou, Yijian Zhang, Tao Liu, Huilin Yang, Xuesong Zhu & Fan He

  2. Orthopaedic Institute, Medical College, Soochow University, No.708 Renmin Road, Suzhou, 215007, Jiangsu, China

    Mingzhuang Hou, Yijian Zhang, Huilin Yang, Xuesong Zhu & Fan He

  3. School of Public Health and Health Systems, University of Waterloo, Waterloo, ON, NZL 3G1, Canada

    Angela Carley Chen

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  1. Mingzhuang Hou
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  4. Tao Liu
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Contributions

YZ and FH designed the research study; MH, YZ, ACC, TL, XZ and FH performed the data analysis; MH wrote the paper; HY participated in the conception of the study and revision of the manuscript. MH and YZ contributed equally to this work. MH, YZ, and TL collected the data. TL and HY provided statistical guidance. MH, YZ, and ACC, and XZ interpreted the statistical findings. MH and FH wrote the paper. All authors participated in the study's conception and approved of the final version to be published.

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Correspondence to Xuesong Zhu or Fan He.

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Hou, M., Zhang, Y., Chen, A.C. et al. The effects of dementia on the prognosis and mortality of hip fracture surgery: a systematic review and meta-analysis. Aging Clin Exp Res 33, 3161–3172 (2021). https://doi.org/10.1007/s40520-021-01864-5

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