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Antimicrobial Peptides

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Abstract

Purpose of Review

The review provides deep understanding on antimicrobial peptides, properties, mechanisms, role in treating diseases, computational drug design, and database updates.

Recent Findings

Recent research has highlighted the growing concern of antibiotic resistance, and has prompted the search for alternative treatments. In response, advances in technology have led to the discovery of novel antimicrobial peptides from a variety of organisms. These peptides are being investigated as potential therapeutics for communicable diseases in humans, animals, and plants. However, a major challenge is to ensure that the effectiveness of these peptides in treating infections is not compromised by the development of resistance. Currently, there is ongoing research to evaluate the safety and efficacy of these novel AMPs in clinical trials, and to determine their potential role in the drug market.

Summary

Microbes, including COVID-19, biofilm-related infections, and antimicrobial resistance, are significant threats to human health. AMPs have potential as effective treatments due to their broad-spectrum activity and specific modes of action. However, developing AMPs as drugs may be limited by factors such as toxicity, protease susceptibility and high production costs.

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Acknowledgements

The authors are very much grateful to School of Life Sciences, B S Abdur Rahman Crescent Institute of Science and Technology, Chennai for providing research facilities and also for their constant support and encouragement.

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  1. School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science & Technology, Vandalur, Chennai, TamilNadu, India

    Noorul Samsoon Maharifa Haja Mohaideen, S. Vaani & S. Hemalatha

  2. Department of Microbiology, Velumanoharan Arts and Science College for Women, Marapalam, TamilNadu, India

    Noorul Samsoon Maharifa Haja Mohaideen

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NSMH analyzed data, designed art work, and wrote manuscript. VS analyzed data, and wrote manuscript. HS Conceived supervised and involved in validation and project administration and edited manuscript.

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Mohaideen, N.S.M.H., Vaani, S. & Hemalatha, S. Antimicrobial Peptides. Curr. Pharmacol. Rep. 9, 433–454 (2023). https://doi.org/10.1007/s40495-023-00342-y

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