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Determinants and Assessment of Menstrual Blood Flow

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Abstract

Purpose of Review

The modifiable and non-modifiable determinants and the currently available methods of assessment of menstrual blood flow will be discussed, with the goal of helping healthcare providers, researchers, and those interested in public health.

Recent Findings

Several factors can impact menstruation. The determinants include modifiable factors such as smoking, nutrition, exercise, stress, weight fluctuation, and benign gynecologic diseases, and non-modifiable factors such as age, race, and the individual’s genes. The intertwined dynamic among these determinants needs more critical attention. Currently, the methods for the assessment of menstruation all have advantages and disadvantages, often with a tradeoff between practicality and accuracy.

Summary

Considered by many as the fifth vital, menstruation provides a window to an individual’s general health. The discussion of its determinants and assessment can be more appropriate for individual contexts, especially from a public health perspective as it can improve the reproductive health of the population.

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References

  1. Menstrual Cycles as a Fifth Vital Sign | NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development 2021. https://www.nichd.nih.gov/about/org/od/directors_corner/prev_updates/menstrual-cycles (accessed May 16, 2023).

  2. Bae J, Park S, Kwon J-W. Factors associated with menstrual cycle irregularity and menopause. BMC Womens Health. 2018;18:36. https://doi.org/10.1186/s12905-018-0528-x.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Reed BG, Carr BR. The normal menstrual cycle and the control of ovulation. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dhatariya K, et al., editors. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2000.

    Google Scholar 

  4. Mihm M, Gangooly S, Muttukrishna S. The normal menstrual cycle in women. Anim Reprod Sci. 2011;124:229–36. https://doi.org/10.1016/j.anireprosci.2010.08.030.

    Article  CAS  PubMed  Google Scholar 

  5. Diagnosis of Abnormal Uterine Bleeding in Reproductive-Aged Women n.d. https://www.acog.org/en/clinical/clinical-guidance/practice-bulletin/articles/2012/07/diagnosis-of-abnormal-uterine-bleeding-in-reproductive-aged-women (accessed February 19, 2023).

  6. Marnach ML, Laughlin-Tommaso SK. Evaluation and management of abnormal uterine bleeding. Mayo Clin Proc. 2019;94:326–35. https://doi.org/10.1016/j.mayocp.2018.12.012.

    Article  PubMed  Google Scholar 

  7. Munro MG, Critchley HOD, Fraser IS, FIGO Menstrual Disorders Committee. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet. 2018;143:393–408. https://doi.org/10.1002/ijgo.12666.

    Article  PubMed  Google Scholar 

  8. Female Reproductive Endocrinology - Gynecology and Obstetrics. Merck Manuals Professional Edition n.d. https://www.merckmanuals.com/professional/gynecology-and-obstetrics/female-reproductive-endocrinology/female-reproductive-endocrinology (accessed July 16, 2023).

  9. Monis CN, Tetrokalashvili M. Menstrual cycle proliferative and follicular phase. StatPearls, Treasure Island (FL): StatPearls Publishing; 2023.

    Google Scholar 

  10. Thiyagarajan DK, Basit H, Jeanmonod R. Physiology, menstrual cycle. StatPearls, Treasure Island (FL): StatPearls Publishing; 2022.

    Google Scholar 

  11. Graafian Follicles - an overview | ScienceDirect Topics n.d. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/graafian-follicles (accessed November 21, 2022).

  12. Granot I, Gnainsky Y, Dekel N. Endometrial inflammation and effect on implantation improvement and pregnancy outcome. Reproduction. 2012;144:661–8. https://doi.org/10.1530/REP-12-0217.

    Article  CAS  PubMed  Google Scholar 

  13. Chumlea WC, Schubert CM, Roche AF, Kulin HE, Lee PA, Himes JH, et al. Age at menarche and racial comparisons in US girls. Pediatrics. 2003;111:110–3. https://doi.org/10.1542/peds.111.1.110.

    Article  PubMed  Google Scholar 

  14. Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, et al. Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod. 2016;31:473–81. https://doi.org/10.1093/humrep/dev318.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Harlow SD, Campbell B. Ethnic differences in the duration and amount of menstrual bleeding during the postmenarcheal period. Am J Epidemiol. 1996;144:980–8. https://doi.org/10.1093/oxfordjournals.aje.a008868.

    Article  CAS  PubMed  Google Scholar 

  16. Lawson CC, Whelan EA, Lividoti Hibert EN, Spiegelman D, Schernhammer ES, Rich-Edwards JW. Rotating shift work and menstrual cycle characteristics. Epidemiology. 2011;22:305–12. https://doi.org/10.1097/EDE.0b013e3182130016.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Jung AN, Park JH, Kim J, Kim SH, Jee BC, Cha BH, et al. Detrimental effects of higher body mass index and smoking habits on menstrual cycles in Korean women. J Womens Health (Larchmt). 2017;26:83–90. https://doi.org/10.1089/jwh.2015.5634.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Grossman MP, Nakajima ST. Menstrual cycle bleeding patterns in cigarette smokers. Contraception. 2006;73:562–5. https://doi.org/10.1016/j.contraception.2006.01.016.

    Article  PubMed  Google Scholar 

  19. Rowland AS, Baird DD, Long S, Wegienka G, Harlow SD, Alavanja M, et al. Influence of medical conditions and lifestyle factors on the menstrual cycle. Epidemiology. 2002;13:668.

    Article  PubMed  Google Scholar 

  20. Magnay JL, O’Brien S, Gerlinger C, Seitz C. Pictorial methods to assess heavy menstrual bleeding in research and clinical practice: a systematic literature review. BMC Womens Health. 2020;20:24. https://doi.org/10.1186/s12905-020-0887-y.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Shaw ST, Aaronson DE, Moyer DL. Quantitation of menstrual blood loss — further evaluation of the alkaline hematin method. Contraception. 1972;5:497–513. https://doi.org/10.1016/0010-7824(72)90015-7.

    Article  PubMed  Google Scholar 

  22. Magnay JL, O’Brien S, Gerlinger C, Seitz C. A systematic review of methods to measure menstrual blood loss. BMC Womens Health. 2018;18:142. https://doi.org/10.1186/s12905-018-0627-8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Onieva-Zafra MD, Fernández-Martínez E, Abreu-Sánchez A, Iglesias-López MT, García-Padilla FM, Pedregal-González M, et al. Relationship between diet, menstrual pain and other menstrual characteristics among Spanish students. Nutrients. 2020;12:1759. https://doi.org/10.3390/nu12061759.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Payne NE, Cross JH, Sander JW, Sisodiya SM. The ketogenic and related diets in adolescents and adults--a review. Epilepsia. 2011;52:1941–8. https://doi.org/10.1111/j.1528-1167.2011.03287.x.

    Article  PubMed  Google Scholar 

  25. Mady MA, Kossoff EH, McGregor AL, Wheless JW, Pyzik PL, Freeman JM. The ketogenic diet: adolescents can do it, too. Epilepsia. 2003;44:847–51. https://doi.org/10.1046/j.1528-1157.2003.57002.x.

    Article  PubMed  Google Scholar 

  26. Pirke KM, Schweiger U, Laessle R, Dickhaut B, Schweiger M, Waechtler M. Dieting influences the menstrual cycle: vegetarian versus nonvegetarian diet**Supported by a grant from the German Federal Government (Ministerium für Forschung und Technologie) grant no. 187490. Fertil Steril. 1986;46:1083–8. https://doi.org/10.1016/S0015-0282(16)49884-5.

    Article  CAS  PubMed  Google Scholar 

  27. Drosdzol-Cop A, Bąk-Sosnowska M, Sajdak D, Białka A, Kobiołka A, Franik G, et al. Assessment of the menstrual cycle, eating disorders and self-esteem of Polish adolescents. J Psychos Obst Gynecol. 2017;38:30–6. https://doi.org/10.1080/0167482X.2016.1216959.

    Article  Google Scholar 

  28. Pedersen AB, Bartholomew MJ, Dolence LA, Aljadir LP, Netteburg KL, Lloyd T. Menstrual differences due to vegetarian and nonvegetarian diets. Am J Clin Nutr. 1991;53:879–85. https://doi.org/10.1093/ajcn/53.4.879.

    Article  CAS  PubMed  Google Scholar 

  29. Bajalan Z, Alimoradi Z, Moafi F. Nutrition as a potential factor of primary dysmenorrhea: a systematic review of observational studies. Gynecol Obstet Invest. 2019;84:209–24. https://doi.org/10.1159/000495408.

    Article  PubMed  Google Scholar 

  30. Ålgars M, Huang L, Von Holle AF, Peat CM, Thornton LM, Lichtenstein P, et al. Binge eating and menstrual dysfunction. J Psychos Res. 2014;76:19–22. https://doi.org/10.1016/j.jpsychores.2013.11.011.

    Article  Google Scholar 

  31. Martini MG, Solmi F, Krug I, Karwautz A, Wagner G, Fernandez-Aranda F, et al. Associations between eating disorder diagnoses, behaviors, and menstrual dysfunction in a clinical sample. Arch Womens Ment Health. 2016;19:553–7. https://doi.org/10.1007/s00737-015-0576-2.

    Article  PubMed  Google Scholar 

  32. Roberts RE, Farahani L, Webber L, Jayasena C. Current understanding of hypothalamic amenorrhoea. Therap Adv Endocrinol. 2020;11:204201882094585. https://doi.org/10.1177/2042018820945854.

    Article  Google Scholar 

  33. Wiksten-Almströmer M, Lindén Hirschberg A, Hagenfeldt K. Menstrual disorders and associated factors among adolescent girls visiting a youth clinic. Acta Obstet Gynecol Scand. 2007;86:65–72. https://doi.org/10.1080/00016340601034970.

    Article  PubMed  Google Scholar 

  34. Mena GP, Mielke GI, Brown WJ. Prospective associations between physical activity and BMI with irregular periods and heavy menstrual bleeding in a large cohort of Australian women. Human Reprod. 2021;36:1481–91. https://doi.org/10.1093/humrep/deab055.

    Article  Google Scholar 

  35. Vyver E, Steinegger C, Katzman DK. Eating disorders and menstrual dysfunction in adolescents. Annals New York Acad Sci. 2008;1135:253–64. https://doi.org/10.1196/annals.1429.013.

    Article  Google Scholar 

  36. Poyastro Pinheiro A, Thornton LM, Plotonicov KH, Tozzi F, Klump KL, Berrettini WH, et al. Patterns of menstrual disturbance in eating disorders. Int J Eat Disord. 2007;40:424–34. https://doi.org/10.1002/eat.20388.

    Article  PubMed  Google Scholar 

  37. Seif MW, Diamond K, Nickkho-Amiry M. Obesity and menstrual disorders. Best Pract Res Clin Obst Gynaecol. 2015;29:516–27. https://doi.org/10.1016/j.bpobgyn.2014.10.010.

    Article  Google Scholar 

  38. Stoegerer-Hecher E, Kirchengast S, Huber JC, Hartmann B. Amenorrhea and BMI as independent determinants of patient satisfaction in LNG-IUD users: cross-sectional study in a Central European district. Gynecol Endocrinol. 2012;28:119–24. https://doi.org/10.3109/09513590.2011.588751.

    Article  PubMed  Google Scholar 

  39. Assessing Your Weight and Health Risk n.d. https://www.nhlbi.nih.gov/health/educational/lose_wt/risk.htm (accessed February 19, 2023).

  40. Bryant M, Truesdale KP, Dye L. Modest changes in dietary intake across the menstrual cycle: implications for food intake research. Br J Nutr. 2006;96:888–94. https://doi.org/10.1017/BJN20061931.

    Article  CAS  PubMed  Google Scholar 

  41. Huhmann K. Menses requires energy: a review of how disordered eating, excessive exercise, and high stress lead to menstrual irregularities. Clin Ther. 2020;42:401–7. https://doi.org/10.1016/j.clinthera.2020.01.016.

    Article  PubMed  Google Scholar 

  42. Huhmann K. Menses requires energy: a review of how disordered eating, excessive exercise, and high stress lead to menstrual irregularities. Clin Ther. 2020;42:401–7. https://doi.org/10.1016/j.clinthera.2020.01.016.

    Article  PubMed  Google Scholar 

  43. Song S, Choi H, Pang Y, Kim O, Park H-Y. Factors associated with regularity and length of menstrual cycle: Korea Nurses’ Health Study. BMC Women’s Health. 2022;22:361. https://doi.org/10.1186/s12905-022-01947-z.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Nagma S. To evaluate the effect of perceived stress on menstrual function. JCDR. 2015; https://doi.org/10.7860/JCDR/2015/6906.5611.

  45. De Souza MJ, Toombs RJ, Scheid JL, O’Donnell E, West SL, Williams NI. High prevalence of subtle and severe menstrual disturbances in exercising women: confirmation using daily hormone measures. Human Reprod. 2010;25:491–503. https://doi.org/10.1093/humrep/dep411.

    Article  CAS  Google Scholar 

  46. Bernstein L, Ross RK, Lobo RA, Hanisch R, Krailo MD, Henderson BE. The effects of moderate physical activity on menstrual cycle patterns in adolescence: implications for breast cancer prevention. Br J Cancer. 1987;55:681–5. https://doi.org/10.1038/bjc.1987.139.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Hahn K, Wise L, Riis, Mikkelsen, Rothman, Banholzer, et al. Correlates of menstrual cycle characteristics among nulliparous Danish women. CLEP 2013:311. https://doi.org/10.2147/CLEP.S46712.

  48. Motzer SA, Hertig V. Stress, stress response, and health. Nurs Clin North Am. 2004;39:1–17. https://doi.org/10.1016/j.cnur.2003.11.001.

    Article  PubMed  Google Scholar 

  49. Jung E-K, Kim S-W, Ock S-M, Jung K-I, Song C-H. Prevalence and related factors of irregular menstrual cycles in Korean women: the 5th Korean National Health and Nutrition Examination Survey (KNHANES-V, 2010-2012). J Psychosom Obstet Gynaecol. 2018;39:196–202. https://doi.org/10.1080/0167482X.2017.1321631.

    Article  PubMed  Google Scholar 

  50. Yu M, Han K, Nam GE. The association between mental health problems and menstrual cycle irregularity among adolescent Korean girls. J Affect Disord. 2017;210:43–8. https://doi.org/10.1016/j.jad.2016.11.036.

    Article  PubMed  Google Scholar 

  51. Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188:100–7. https://doi.org/10.1067/mob.2003.99.

    Article  PubMed  Google Scholar 

  52. Vercellini P, Frattaruolo MP. Uterine fibroids: from observational epidemiology to clinical management. BJOG. 2017;124:1513. https://doi.org/10.1111/1471-0528.14730.

    Article  CAS  PubMed  Google Scholar 

  53. Vannuccini S, Jain V, Critchley H, Petraglia F. From menarche to menopause, heavy menstrual bleeding is the underrated compass in reproductive health. Fertil Steril. 2022;118:625–36. https://doi.org/10.1016/j.fertnstert.2022.07.021.

    Article  PubMed  Google Scholar 

  54. Dueholm M. Transvaginal ultrasound for diagnosis of adenomyosis: a review. Best Pract Res Clin Obstet Gynaecol. 2006;20:569–82. https://doi.org/10.1016/j.bpobgyn.2006.01.005.

    Article  PubMed  Google Scholar 

  55. Benagiano G, Brosens I, Habiba M. Structural and molecular features of the endomyometrium in endometriosis and adenomyosis. Hum Reprod Update. 2014;20:386–402. https://doi.org/10.1093/humupd/dmt052.

    Article  CAS  PubMed  Google Scholar 

  56. Smolarz B, Szyłło K, Romanowicz H. Endometriosis: epidemiology, classification, pathogenesis, treatment and genetics (review of literature). Int J Mol Sci. 2021;22:10554. https://doi.org/10.3390/ijms221910554.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Savelli L, De Iaco P, Santini D, Rosati F, Ghi T, Pignotti E, et al. Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps. Am J Obstet Gynecol. 2003;188:927–31. https://doi.org/10.1067/mob.2003.247.

    Article  PubMed  Google Scholar 

  58. Salim S, Won H, Nesbitt-Hawes E, Campbell N, Abbott J. Diagnosis and management of endometrial polyps: a critical review of the literature. J Minim Invasive Gynecol. 2011;18:569–81. https://doi.org/10.1016/j.jmig.2011.05.018.

    Article  CAS  PubMed  Google Scholar 

  59. Nappi L, Indraccolo U, Di Spiezio SA, Gentile G, Palombino K, Castaldi MA, et al. Are diabetes, hypertension, and obesity independent risk factors for endometrial polyps? J Minim Invasive Gynecol. 2009;16:157–62. https://doi.org/10.1016/j.jmig.2008.11.004.

    Article  PubMed  Google Scholar 

  60. Matteson KA, Zaluski KM. Menstrual health as a part of preventive health care. Obstet Gynecol Clin North Am. 2019;46:441–53. https://doi.org/10.1016/j.ogc.2019.04.004.

    Article  PubMed  Google Scholar 

  61. Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016;106:6–15. https://doi.org/10.1016/j.fertnstert.2016.05.003.

    Article  PubMed  Google Scholar 

  62. Lentscher JA, Decherney AH. Clinical presentation and diagnosis of polycystic ovarian syndrome. Clin Obst Gynecol. 2021;64:3–11. https://doi.org/10.1097/GRF.0000000000000563.

    Article  Google Scholar 

  63. Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10:668–80. https://doi.org/10.1016/S2213-8587(22)00163-2.

    Article  CAS  PubMed  Google Scholar 

  64. Copp T, Doust J, McCaffery K, Hersch J, Jansen J. Polycystic ovary syndrome: why widening the diagnostic criteria may be harming women. BMJ. 2021;373:n700. https://doi.org/10.1136/bmj.n700.

    Article  PubMed  Google Scholar 

  65. Rundell K, Panchal B. Being reproductive. Primary Care: Clin Office Pract. 2018;45:587–98. https://doi.org/10.1016/j.pop.2018.07.003.

    Article  Google Scholar 

  66. Elting MW, Korsen TJ, Rekers-Mombarg LT, Schoemaker J. Women with polycystic ovary syndrome gain regular menstrual cycles when ageing. Hum Reprod. 2000;15:24–8. https://doi.org/10.1093/humrep/15.1.24.

    Article  CAS  PubMed  Google Scholar 

  67. Moran LJ, Pasquali R, Teede HJ, Hoeger KM, Norman RJ. Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Fertil Steril. 2009;92:1966–82. https://doi.org/10.1016/j.fertnstert.2008.09.018.

    Article  PubMed  Google Scholar 

  68. Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013;98:4565–92. https://doi.org/10.1210/jc.2013-2350.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Walker K, Decherney AH, Saunders R. Menstrual dysfunction in PCOS. Clin Obst Gynecol. 2021;64:119. https://doi.org/10.1097/GRF.0000000000000596.

    Article  Google Scholar 

  70. Polycystic Ovary Syndrome n.d. https://www.acog.org/en/clinical/clinical-guidance/practice-bulletin/articles/2018/06/polycystic-ovary-syndrome (accessed February 19, 2023).

  71. Deligeoroglou E, Karountzos V. Abnormal Uterine Bleeding including coagulopathies and other menstrual disorders. Best Pract Res Clin Obstet Gynaecol. 2018;48:51–61. https://doi.org/10.1016/j.bpobgyn.2017.08.016.

    Article  PubMed  Google Scholar 

  72. Wallace RB, Sherman BM, Bean JA, Treloar AE, Schlabaugh L. Probability of menopause with increasing duration of amenorrhea in middle-aged women. Am J Obst Gynecol. 1979;135:1021–4. https://doi.org/10.1016/0002-9378(79)90729-4.

    Article  CAS  Google Scholar 

  73. Harlow SD. Menstrual cycle changes as women approach the final menses: what matters? Obst Gynecol Clin North Am. 2018;45:599–611. https://doi.org/10.1016/j.ogc.2018.07.003.

    Article  Google Scholar 

  74. Diagnosis and treatment of luteal phase deficiency: a committee opinion. Fertil Steril. 2021;115:1416–23. https://doi.org/10.1016/j.fertnstert.2021.02.010.

  75. Deligeoroglou E, Karountzos V, Creatsas G. Abnormal uterine bleeding and dysfunctional uterine bleeding in pediatric and adolescent gynecology. Gynecol Endocrinol. 2013;29:74–8. https://doi.org/10.3109/09513590.2012.705384.

    Article  PubMed  Google Scholar 

  76. Peer RF, Shabir N. Iatrogenesis: A review on nature, extent, and distribution of healthcare hazards. J Family Med Prim Care. 2018;7:309–14. https://doi.org/10.4103/jfmpc.jfmpc_329_17.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Healy MW, Schexnayder B, Connell MT, Terry N, DeCherney AH, Csokmay JM, et al. Intrauterine adhesion prevention after hysteroscopy: a systematic review and meta-analysis. Am J Obstet Gynecol. 2016;215:267–275.e7. https://doi.org/10.1016/j.ajog.2016.05.001.

    Article  PubMed  Google Scholar 

  78. Matsuoka M, Taga A, Hata S, Yamamoto R, Ando Y, Kozono Y, et al. Abnormal menstruation after radical trachelectomy and its effects on fertility. J Obst Gynaecol Res. 2019;45:1906–12. https://doi.org/10.1111/jog.14032.

    Article  Google Scholar 

  79. Djuwantono T, Permadi W, Septiani L, Faried A, Halim D, Parwati I. Female genital tuberculosis and infertility: serial cases report in Bandung, Indonesia and literature review. BMC Res Notes. 2017;10:683. https://doi.org/10.1186/s13104-017-3057-z.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Brown DL. Congenital bleeding disorders. Curr Problems in Pediatr Adole Health Care. 2005;35:38–62. https://doi.org/10.1016/j.cppeds.2004.12.001.

    Article  Google Scholar 

  81. Hallberg L, Hôgdahl A-M, Nilsson L, Rybo G. Menstrual blood loss–a population study. Acta Obstetricia et Gynecologica Scandinavica. 1966;45:320–51. https://doi.org/10.3109/00016346609158455.

    Article  CAS  PubMed  Google Scholar 

  82. Warner PE, Critchley HOD, Lumsden MA, Campbell-Brown M, Douglas A, Murray GD. Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data. Am J Obst Gynecol. 2004;190:1216–23. https://doi.org/10.1016/j.ajog.2003.11.015.

    Article  Google Scholar 

  83. Heavy menstrual bleeding: assessment and management 2021.

  84. Camaschella C. Iron deficiency. Blood. 2019;133:30–9. https://doi.org/10.1182/blood-2018-05-815944.

    Article  CAS  PubMed  Google Scholar 

  85. van Eijkeren MA, Scholten PC, Christiaens GCML, Alsbach GPJ, Haspels AA. The alkaline hematin method for measuring menstrual blood loss — a modification and its clinical use in menorrhagia. Eur J Obst Gynecol Reprod Biol. 1986;22:345–51. https://doi.org/10.1016/0028-2243(86)90124-3.

    Article  Google Scholar 

  86. Higham JM, O’Brien PM, Shaw RW. Assessment of menstrual blood loss using a pictorial chart. Br J Obstet Gynaecol. 1990;97:734–9. https://doi.org/10.1111/j.1471-0528.1990.tb16249.x.

    Article  CAS  PubMed  Google Scholar 

  87. Worsfold L, Marriott L, Johnson S, Harper JC. Period tracker applications: what menstrual cycle information are they giving women? Womens Health (Lond). 2021;17:17455065211049904. https://doi.org/10.1177/17455065211049905.

    Article  CAS  Google Scholar 

  88. Krishnamurti T, Birru Talabi M, Callegari LS, Kazmerski TM, Borrero S. A framework for Femtech: guiding principles for developing digital reproductive health tools in the United States. J Med Internet Res. 2022;24:e36338. https://doi.org/10.2196/36338.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Fraser IS, Warner P, Marantos PA. Estimating menstrual blood loss in women with normal and excessive menstrual fluid volume. Obstet Gynecol. 2001;98:806–14. https://doi.org/10.1016/s0029-7844(01)01581-2.

    Article  CAS  PubMed  Google Scholar 

  90. Schumacher U, Schumacher J, Mellinger U, Gerlinger C, Wienke A, Endrikat J. Estimation of menstrual blood loss volume based on menstrual diary and laboratory data. BMC Womens Health. 2012;12:24. https://doi.org/10.1186/1472-6874-12-24.

    Article  PubMed  PubMed Central  Google Scholar 

  91. Wyatt KM, Dimmock PW, Walker TJ, O’Brien PMS. Determination of total menstrual blood loss. Fertil Steril. 2001;76:125–31. https://doi.org/10.1016/S0015-0282(01)01847-7.

    Article  CAS  PubMed  Google Scholar 

  92. What Your Period Tracker App Knows About You. Consumer Reports n.d. https://www.consumerreports.org/health-privacy/what-your-period-tracker-app-knows-about-you-a8701683935/ (accessed November 26, 2022).

  93. Pichon A, Jackman KB, Winkler IT, Bobel C, Elhadad N. The messiness of the menstruator: assessing personas and functionalities of menstrual tracking apps. J Am Med Inform Assoc. 2021;29:385–99. https://doi.org/10.1093/jamia/ocab212.

    Article  PubMed Central  Google Scholar 

  94. Dkeidek A, Mattinson R, Grover SR. Bleeding disorders: are gynaecologists testing women at risk? Haemophilia. 2021;27:e534–6. https://doi.org/10.1111/hae.14283.

    Article  PubMed  Google Scholar 

  95. Rochester D, Jain A, Polotsky AJ, Polotsky H, Gibbs K, Isaac B, et al. Partial recovery of luteal function after bariatric surgery in obese women. Fertil Steril. 2009;92:1410–5. https://doi.org/10.1016/j.fertnstert.2008.08.025.

    Article  CAS  PubMed  Google Scholar 

  96. Simons PIHG, Cornelissen MEB, Valkenburg O, Onland-Moret NC, van der Schouw YT, Stehouwer CDA, et al. Causal relationship between polycystic ovary syndrome and coronary artery disease: a Mendelian randomisation study. Clin Endocrinol (Oxf). 2022;96:599–604. https://doi.org/10.1111/cen.14593.

    Article  PubMed  Google Scholar 

  97. Álvarez-Blasco F, Botella-Carretero JI, San Millán JL, Escobar-Morreale HF. Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women. Arch Int Med. 2006;166:2081–6. https://doi.org/10.1001/archinte.166.19.2081.

    Article  Google Scholar 

  98. Li R, Zhang Q, Yang D, Li S, Lu S, Wu X, et al. Prevalence of polycystic ovary syndrome in women in China: a large community-based study. Hum Reprod. 2013;28:2562–9. https://doi.org/10.1093/humrep/det262.

    Article  PubMed  Google Scholar 

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Funding

This work was supported, in part, by NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) grant 3R01HD094380-04S1.

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Jinxiao Liang, Fiza Ali, and Malini Ramaiyer wrote the main manuscript text and Jinxiao Liang prepared Figure 1. Mostafa A. Borahay supervised the manuscript. All authors reviewed the manuscript.

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Correspondence to Mostafa A. Borahay.

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Liang, J., Ali, F., Ramaiyer, M. et al. Determinants and Assessment of Menstrual Blood Flow. Curr Epidemiol Rep 10, 210–220 (2023). https://doi.org/10.1007/s40471-023-00332-0

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