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Exploratory mathematical frameworks and design of control systems for the automation of propofol anesthesia

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Abstract

A variety of automatic control systems are increasingly being deployed to assist clinicians to monitor patient functioning and enhance healthcare delivery during surgical procedures. This article deals with the mathematical design framework of closed-loop infusion schemes for propofol delivery in general anesthesia. The main emphasis of this research series is to come up with a better-performing control system which could handle the clinical concerns of automation-based anesthesia without compromise of safety. Also, the research is geared at studying the performance of these plausible control-based automatic drug infusion patterns in a computer environment prior to actual clinical implementation. The study advances the design of effective model-based predictive control (MPC) strategies familiar to engineers in the process industries, as well as a preliminary design of a proportional–integral–derivative (PID) controller. The consideration of the traditional PID controller is followed by two linear MPC strategies and a nonlinear one. These varieties of closed-loop infusion strategies were designed in order to make well-informed comparison and assessment of the promising method(s) of control for the sought clinical application. The successive linearization technique is being applied in novelty to anesthesia in this work. The results indicate that the MPC controllers show great promise for adoption for automated drug delivery in anesthesia delivering better performance. This sets the pace for future investigations which may assess, via pseudo-clinical in silico studies, the deployment of the controllers.

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reproduced from The MathWorks, 2004 [19]

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Acknowledgements

The guidance of Prof. Yi Cao is acknowledged during the conduct of the research at Cranfield University. Also, the financial sponsorship of the PTDF Nigeria provided to the author in the form of postgraduate study scholarship is acknowledged.

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Authors and Affiliations

  1. Department of Chemical Engineering, College of Engineering, Landmark University, PMB 1001, Omu-Aran, Kwara State, Nigeria

    Temitope A. Oshin

  2. Landmark University SDG 3 Cluster (Good Health and Well-Being), PMB 1001, Omu-Aran, Kwara State, Nigeria

    Temitope A. Oshin

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Correspondence to Temitope A. Oshin.

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I hereby declare that this manuscript is the result of my independent creation under the reviewers’ comments. Except for the quoted contents, this manuscript does not contain any research achievements that have been published or written by other individuals or groups. I am the only author of this manuscript. The legal responsibility of this statement shall be borne by me.

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Oshin, T.A. Exploratory mathematical frameworks and design of control systems for the automation of propofol anesthesia. Int. J. Dynam. Control 10, 1858–1875 (2022). https://doi.org/10.1007/s40435-022-00953-1

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  • DOI: https://doi.org/10.1007/s40435-022-00953-1

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