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Topographical patterns of whole-brain structural alterations in association with genetic risk, cerebrospinal fluid, positron emission tomography biomarkers of Alzheimer’s disease, and neuropsychological measures

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Abstract

Purpose

This study aimed at investigating the topographical pattern of whole-brain structural alterations in association with apolipoprotein E ε4 (APOE ε4), cerebrospinal fluid (CSF) [amyloid-beta 42 (Aβ42), and neurofibrillary tau protein], positron emission tomography (PET) biomarkers [Aβ, tau, and 2-[18F]fluoro-2-deoxy-d-glucose (FDG)], and neuropsychological measures.

Methods

PubMed, Scopus, Ovid, and Cochrane databases were searched. Risk of bias (using a modified Newcastle–Ottawa Scale) and level of evidence were determined.

Results

One hundred and thirty-one studies met the inclusion criteria. APOE ε4 effect is exerted on the whole-brain. Still, the medial temporal lobe is the most affected, with moderate evidence observed across the lifespan (except late mid-life) and in the AD continuum. Moderate to strong evidence shows that atrophy of AD-vulnerable regions is associated with reduced CSF Aβ42, increased Aβ- and tau-PET, and increased CSF tau. No association between gray matter changes and FDG-PET measures in healthy late mid-life and older adults. Preliminary findings demonstrate a relationship between hippocampal atrophy and lower episodic memory in early life. Moderate evidence of an association between hippocampal atrophy and lower episodic memory is observed in late mid-life. In contrast, hippocampal atrophy is associated with reduced episodic memory and global cognition in older APOE ε4 carriers.

Conclusions

Strong evidence suggests that atrophy of the AD vulnerable regions is associated with CSF and PET biomarkers and cognitive measures. These relationships may be potentially helpful in characterizing the preclinical and clinical stages of MCI and AD and predicting AD progression.

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Authors and Affiliations

  1. Diagnostic Imaging and Radiotherapy Programme, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia

    Albert Dayor Piersson & Mazlyfarina Mohamad

  2. Department of Imaging Technology and Sonography, School of Allied Health Sciences, University of Cape Coast, University Post Office, Cape Coast, Ghana

    Albert Dayor Piersson

  3. Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia

    Subapriya Suppiah

  4. Biomedical Science Programme, Center for Healthy Aging and Wellness, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia

    Nor Fadilah Rajab

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  1. Albert Dayor Piersson
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  2. Mazlyfarina Mohamad
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  4. Nor Fadilah Rajab
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Conception and study design (ADP), data collection (ADP), interpretation of results (ADP, MM, and SS); drafting the manuscript work (ADP), revising manuscript (ADP, MM, SS, and NFR); approval of final version to be published and agreement to be accountable for the integrity and accuracy of all aspects of the work (ADP, MM, SS, and NFR).

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Correspondence to Mazlyfarina Mohamad.

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Piersson, A.D., Mohamad, M., Suppiah, S. et al. Topographical patterns of whole-brain structural alterations in association with genetic risk, cerebrospinal fluid, positron emission tomography biomarkers of Alzheimer’s disease, and neuropsychological measures. Clin Transl Imaging 9, 439–497 (2021). https://doi.org/10.1007/s40336-021-00440-1

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