Skip to main content
SpringerLink
Log in

Antipsychotic drugs may increase the risk of venous thromboembolism

  • Drug Reactions and Interactions
  • Published:
Drugs & Therapy Perspectives Aims and scope Submit manuscript

Abstract

A wide range of observational studies have demonstrated an increased risk of venous thromboembolism (VTE) in patients receiving antipsychotic drugs. Although current data cannot conclusively verify differences in VTE occurrence rates between individual antipsychotic drugs or different generations thereof, information is sufficient to warrant an increased awareness of this potentially serious adverse drug reaction, as well as consideration of prophylactic antithrombotic therapy in at-risk patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Beckman MG, Hooper WC, Critchley SE, et al. Venous thromboembolism: a public health concern. Am J Prev Med. 2010;38(4 Suppl):S495–501.

    Article  Google Scholar 

  2. Raskob GE, Angchaisuksiri P, Blanco AN, et al. Thrombosis: a major contributor to the global disease burden. J Thromb Haemost. 2014;12(10):1580–90.

    Article  Google Scholar 

  3. Wells P, Anderson D. The diagnosis and treatment of venous thromboembolism. Hematol Am Soc Hematol Educ Program. 2013;2013:457–63.

    Article  Google Scholar 

  4. Jönsson AK, Schill J, Olsson H, et al. Venous thromboembolism during treatment with antipsychotics: a review of current evidence. CNS Drugs. 2018;32(1):47–64.

    Article  Google Scholar 

  5. Lacut K, Le Gal G, Couturaud F, et al. Association between antipsychotic drugs, antidepressant drugs and venous thromboembolism: results from the EDITH case–control study. Fundam Clin Pharmacol. 2007;21(6):643–50.

    Article  CAS  Google Scholar 

  6. Jönsson AK, Horvath-Puho E, Hagg S, et al. Antipsychotics and risk of venous thromboembolism: a population-based case–control study. Clin Epidemiol. 2009;1:19–26.

    Article  Google Scholar 

  7. Parker C, Coupland C, Hippisley-Cox J. Antipsychotic drugs and risk of venous thromboembolism: nested case–control study. BMJ. 2010;341:c4245.

    Article  Google Scholar 

  8. Ishiguro C, Wang X, Li L, et al. Antipsychotic drugs and risk of idiopathic venous thromboembolism: a nested case–control study using the CPRD. Pharmacoepidemiol Drug Saf. 2014;23(11):1168–75.

    Article  CAS  Google Scholar 

  9. Wu CS, Lin CC, Chang CM, et al. Antipsychotic treatment and the occurrence of venous thromboembolism: a 10-year nationwide registry study. J Clin Psychiatry. 2013;74(9):918–24.

    Article  CAS  Google Scholar 

  10. Wang MT, Liou JT, Huang YW, et al. Use of antipsychotics and risk of venous thromboembolism in postmenopausal women: a population-based nested case–control study. Thromb Haemost. 2016;115(6):1209–19.

    Article  Google Scholar 

  11. Conti V, Venegoni M, Cocci A, et al. Antipsychotic drug exposure and risk of pulmonary embolism: a population-based, nested case–control study. BMC Psychiatry. 2015;15:92.

    Article  Google Scholar 

  12. Kleijer BC, Heerdink ER, Egberts TC, et al. Antipsychotic drug use and the risk of venous thromboembolism in elderly patients. J Clin Psychopharmacol. 2010;30(5):526–30.

    Article  CAS  Google Scholar 

  13. Schmedt N, Garbe E. Antipsychotic drug use and the risk of venous thromboembolism in elderly patients with dementia. J Clin Psychopharmacol. 2013;33(6):753–8.

    Article  CAS  Google Scholar 

  14. Allenet B, Schmidlin S, Genty C, et al. Antipsychotic drugs and risk of pulmonary embolism. Pharmacoepidemiol Drug Saf. 2012;21(1):42–8.

    Article  CAS  Google Scholar 

  15. Hsu WY, Lane HY, Lin CL, et al. A population-based cohort study on deep vein thrombosis and pulmonary embolism among schizophrenia patients. Schizophr Res. 2015;162(1–3):248–52.

    Article  Google Scholar 

  16. Ferraris A, Szmulewicz AG, Vazquez FJ, et al. Antipsychotic use among adult outpatients and venous thromboembolic disease: a retrospective cohort study. J Clin Psychopharmacol. 2017;37(4):405–11.

    Article  Google Scholar 

  17. Hippisley-Cox J, Coupland C. Development and validation of risk prediction algorithm (QThrombosis) to estimate future risk of venous thromboembolism: prospective cohort study. BMJ. 2011;343:d4656.

    Article  Google Scholar 

  18. Nakamura M, Yamada N, Oda E, et al. Predictors of venous thromboembolism recurrence and the bleeding events identified using a Japanese healthcare database. J Cardiol. 2017;70(2):155–62.

    Article  Google Scholar 

  19. Ray JG, Mamdani MM, Yeo EL. Antipsychotic and antidepressant drug use in the elderly and the risk of venous thromboembolism. Thromb Haemost. 2002;88(2):205–9.

    CAS  PubMed  Google Scholar 

  20. Liperoti R, Pedone C, Lapane KL, et al. Venous thromboembolism among elderly patients treated with atypical and conventional antipsychotic agents. Arch Intern Med. 2005;165(22):2677–82.

    Article  Google Scholar 

  21. Dennis M, Shine L, John A, et al. Risk of adverse outcomes for older people with dementia prescribed antipsychotic medication: a population based e-cohort study. Neurol Ther. 2017;6(1):57–77.

    Article  Google Scholar 

  22. Letmaier M, Grohmann R, Kren C, et al. Venous thromboembolism during treatment with antipsychotics: results of a drug surveillance programme. World J Biol Psychiatry. 2018;19(3):175–86.

    Article  Google Scholar 

  23. Hägg S, Bate A, Stahl M, et al. Associations between venous thromboembolism and antipsychotics: a study of the WHO database of adverse drug reactions. Drug Saf. 2008;31(8):685–94.

    Article  Google Scholar 

  24. Hägg S, Spigset O, Söderström TG. Association of venous thromboembolism and clozapine. Lancet. 2000;355(9210):1155–6.

    Article  Google Scholar 

  25. Barbui C, Conti V, Cipriani A. Antipsychotic drug exposure and risk of venous thromboembolism: a systematic review and meta-analysis of observational studies. Drug Saf. 2014;37(2):79–90.

    Article  CAS  Google Scholar 

  26. Zhang R, Dong L, Shao F, et al. Antipsychotics and venous thromboembolism risk: a meta-analysis. Pharmacopsychiatry. 2011;44(5):183–8.

    Article  CAS  Google Scholar 

  27. Malý R, Masopust J, Hosak L, et al. Assessment of risk of venous thromboembolism and its possible prevention in psychiatric patients. Psychiatry Clin Neurosci. 2008;62(1):3–8.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

    Consortia

    Adis Medical Writers

    Ethics declarations

    Funding

    The preparation of this review was not supported by any external funding.

    Conflict of interest

    The article was adapted from CNS Drugs 2018;32(1):47–64 [4] by employees of Adis/Springer, who are responsible for the article content and declare no conflicts of interest.

    Rights and permissions

    Reprints and permissions

    About this article

    Check for updates. Verify currency and authenticity via CrossMark

    Cite this article

    Adis Medical Writers. Antipsychotic drugs may increase the risk of venous thromboembolism. Drugs Ther Perspect 34, 372–376 (2018). https://doi.org/10.1007/s40267-018-0535-x

    Download citation

    • Published:

    • Issue Date:

    • DOI: https://doi.org/10.1007/s40267-018-0535-x

    Search

    Navigation