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Medications that affect CNS neurotransmitter levels may induce tactile hallucinations

  • Drug Reactions and Interactions
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Abstract

Tactile hallucinations may be induced by some prescription medications, recreational drug use and underlying organic and psychiatric conditions, as well as being a manifestation of monosymptomatic hypochondriacal psychosis. This article reviews the evidence, albeit limited, indicating that tactile hallucinations may be induced by medications that affect CNS neurotransmitter levels (i.e. dopaminergic, serotonergic and anti-adrenergic agents). Medication-induced tactile hallucinations can generally be managed by modifying the dosage of the causative drug or discontinuing treatment.

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References

  1. Nakamura M, Koo J. Drug-Induced tactile hallucinations beyond recreational drugs. Am J Clin Dermatol. 2016;17(6):643–52.

    Article  PubMed  Google Scholar 

  2. Freudenmann RW, Lepping P. Delusional infestation. Clin Microbiol Rev. 2009;22(4):690–732.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Wong JW, Koo JY. Delusions of parasitosis. Indian J Dermatol. 2013;58(1):49–52.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Wykoff RF. Delusions of parasitosis: a review. Rev Infect Dis. 1987;9(3):433–7.

    Article  CAS  PubMed  Google Scholar 

  5. Goetz CG, Vogel C, Tanner CM, et al. Early dopaminergic drug-induced hallucinations in Parkinsonian patients. Neurology. 1998;51:811–4.

    Article  CAS  PubMed  Google Scholar 

  6. Moskovitz C, Moses H, Klawans HL. Levodopa-induced psychosis: a kindling phenomenon. Am J Psychol. 1978;135:669–75.

    Article  CAS  Google Scholar 

  7. Shepherd G, Velez LI, Keyes DC. Intentional bupropion overdoses. J Emerg Med. 2004;27:147–51.

    Article  PubMed  Google Scholar 

  8. Mukonzo JK, Okwera A, Nakasujja N, et al. Influence of efavirenz pharmacokinetics and pharmacogenetics on neuropsychological disorders in Ugandan HIV-positive patients with or without tuberculosis: a prospective cohort study. BMC Infect Dis. 2013;4(13):261.

    Article  Google Scholar 

  9. Swick B, Walling H. Drug-induced delusions of parasitosis during treatment of Parkinson’s disease. J Am Acad Dermatol. 2005;53:1086–7.

    Article  PubMed  Google Scholar 

  10. Wilcox J. Psychoactive properties of amantadine. J Psychoactive Drugs. 1985;17:51–3.

    Article  CAS  PubMed  Google Scholar 

  11. Fenelon G, Thobois S, Bonnet AM, et al. Tactile hallucinations in Parkinson’s disease. J Neurol. 2002;249(12):1699–703.

    Article  PubMed  Google Scholar 

  12. Flann S, Shotbolt J, Kessel B, et al. Three cases of delusional parasitosis caused by dopamine agonists. Clin Exp Dermatol. 2010;35(7):740–2.

    Article  CAS  PubMed  Google Scholar 

  13. Jimenez-Jimenez FJ, Orti-Pareja M, Gasalla T, et al. Cenesthetic hallucinations in a patient with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1997;63(1):120.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Kataoka H, Sawa N, Sugie K, et al. Can dopamine agonists trigger tactile hallucinations in patients with Parkinson’s disease? J Neurol Sci. 2014;347(1–2):361–3.

    Article  CAS  PubMed  Google Scholar 

  15. Peabody CA. Trazodone withdrawal and formication. J Clin Psychiatry. 1987;48(9):385.

    CAS  PubMed  Google Scholar 

  16. Hvizdos AJ, Bennett JA, Wells BG, et al. Anticholinergic psychosis in a patient receiving usual doses of haloperidol, desipramine, and benztropine. Clin Pharm. 1983;2(2):174–8.

    CAS  PubMed  Google Scholar 

  17. Arora GS, Arora HK, Sidhu J, et al. Tactile hallucinations with fluoxetine and methylphenidate. J Child Adolesc Psychopharmacol. 2014;24(6):360–1.

    Article  PubMed  Google Scholar 

  18. Charuvastra A, Yaeger D. Tactile hallucinations associated with therapeutic doses of bupropion in 2 patients. J Clin Psychiatry. 2006;67(11):1820–1.

    Article  PubMed  Google Scholar 

  19. Coskun M, Zoroglu S. Tactile and visual hallucinations in a child with methylphenidate and fluoxetine combination. J Clin Psychopharmacol. 2008;28(6):723–5.

    Article  PubMed  Google Scholar 

  20. Liebowitz MR, Nuetzel EJ, Bowser AE, et al. Phenelzine and delusions of parasitosis: a case report. Am J Psychiatry. 1978;135(12):1565–6.

    Article  CAS  PubMed  Google Scholar 

  21. Liskin B, Roose SP, Walsh BT, et al. Acute psychosis following phenelzine discontinuation. J Clin Psychopharmacol. 1985;5(1):46–7.

    Article  CAS  PubMed  Google Scholar 

  22. Stanciu CN, Penders TM, Oxentine HN. Delusional infestation following misuse of prescription stimulants. Psychosomatics. 2015;56(2):210–2.

    Article  PubMed  Google Scholar 

  23. Buscarino M, Saal J, Young JL. Delusional parasitosis in a female treated with mixed amphetamine salts: a case report and literature review. Case Rep Psychiatry. 2012;2012:624235.

    PubMed  PubMed Central  Google Scholar 

  24. Rashid J, Mitelman S. Methylphenidate and somatic hallucinations. J Am Acad Child Psychiatry. 2007;46(8):945–6.

    Article  Google Scholar 

  25. Young JG. Methylphenidate-induced hallucinosis: case histories and possible mechanisms of action. J Dev Behav Pediatr. 1981;2:35–8.

    Article  CAS  PubMed  Google Scholar 

  26. Horn JR, Rylander ML, Hicks HM. Propranolol-induced hallucinosis. Clin Pharm. 1982;1(5):464–8.

    CAS  PubMed  Google Scholar 

  27. Kurland ML. Organic brain syndrome with propranolol. N Engl J Med. 1979;300(7):366.

    CAS  PubMed  Google Scholar 

  28. Hinshelwood RD. Hallucinations and propranolol. Br Med J. 1969;2:445.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Moreira CA, Soares AR, Maia G. Psychiatric antiepileptics side effects: a case report. Eur Psychiatry. 2016;33(Suppl):S348.

    Google Scholar 

  30. Oh HK, Tebrewal P, Dhillon R. Lamotrigine-induced tactile hallucination. J Clin Psychiatry. 2014;75(11):e1330.

    Article  PubMed  Google Scholar 

  31. Shrestha PV, Syed A, Marwaha R. Lacosamide-induced tactile hallucinations in a patient with complex partial seizures. J Neuropsychiatry Clin Neurosci. 2014;26(3):E8–9.

    Article  PubMed  Google Scholar 

  32. Brandt LJ. Formication and azathioprine therapy. Ann Intern Med. 1977;87(4):458.

    Article  CAS  PubMed  Google Scholar 

  33. Siemianowski LA, Rosenheck JP, Whitman CB. Nalbuphine-induced psychosis treated with naloxone. Am J Health Syst Pharm. 2014;71:717–21.

    Article  CAS  PubMed  Google Scholar 

  34. Selvaraj V, Skaf M, Sharma A, et al. Eszopiclone-induced psychosis. Innov Clin Neurosci. 2012;9(10):11.

    PubMed  PubMed Central  Google Scholar 

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    Adis Medical Writers

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The article was adapted from the American Journal Clinical Dermatology 2016;17(6):643–52 [1] by salaried employees of Adis/Springer and was not supported by any external funding.

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Medical Writers, A. Medications that affect CNS neurotransmitter levels may induce tactile hallucinations. Drugs Ther Perspect 33, 279–282 (2017). https://doi.org/10.1007/s40267-017-0394-x

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