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Vorapaxar: First Global Approval

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Abstract

Vorapaxar [Zontivity® (US)], an orally active protease-activated receptor-1 (PAR-1) receptor antagonist, has been developed by Merck & Co for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). Vorapaxar has received its first global approval for this indication in the US. This article summarizes the milestones in the development of vorapaxar leading to this first approval for the reduction of thrombotic cardiovascular events in patients with a prior MI or PAD.

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Disclosure

The preparation of this report was not supported by any external funding. During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. R.M. Poole is a contracted employee of Adis, Springer SBM. S. Elkinson is a salaried employee of Adis, Springer SBM.

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Authors and Affiliations

  1. Adis, Level 1, 5 The Warehouse Way, Northcote 0627; Private Bag 65901, Mairangi Bay 0754, Auckland, New Zealand

    Shelley Elkinson

  2. Adis, Auckland, New Zealand

    Raewyn M. Poole

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  1. Raewyn M. Poole
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  2. Shelley Elkinson
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Correspondence to Shelley Elkinson.

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Poole, R.M., Elkinson, S. Vorapaxar: First Global Approval. Drugs 74, 1153–1163 (2014). https://doi.org/10.1007/s40265-014-0252-2

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