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Platelet-Rich Plasma to Improve the Bio-Functionality of Biomaterials

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Abstract

Growth factors and cytokines are active players in controlling the different stages of wound healing and tissue regeneration. Recent trends in personalized regenerative medicine involve using patient’s own platelet-rich plasma for stimulating wound healing and tissue regeneration. This technology provides a complex cocktail of growth factors and even a fibrin scaffold with multiple biologic effects. In the last few years, an increasing number of studies provide evidence of the potential of combining platelet-rich plasma with different biomaterials in order to improve their properties, including handling, administration, bioactivity, and level of osseointegration, among others. In this review, we discuss the use of platelet-rich plasma as an alternative, easy, cost-effective, and controllable strategy for the release of high concentrations of many endogenous growth factors. Additionally, we provide an overview of the current progress and future directions of research combining different types of biomaterials with platelet-rich plasma in tissue engineering and regenerative medicine.

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References

  1. Anitua E, Sanchez M, Orive G. Potential of endogenous regenerative technology for in situ regenerative medicine. Adv Drug Deliv Rev. 2010;62(7–8):741–52.

    Article  PubMed  CAS  Google Scholar 

  2. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature. 2000;407(6801):242–8.

    Article  PubMed  CAS  Google Scholar 

  3. Graves DT, Valentin-Opran A, Delgado R, Valente AJ, Mundy G, Piche J. The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells. Connect Tissue Res. 1989;23(2–3):209–18.

    Article  PubMed  CAS  Google Scholar 

  4. Maeda S, Hayashi M, Komiya S, Imamura T, Miyazono K. Endogenous TGF-[beta] signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J. 2004;23(3):552–63.

    Article  PubMed  CAS  Google Scholar 

  5. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nature Med. 2003;9(6):669–76.

    Article  PubMed  CAS  Google Scholar 

  6. Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg. 2002;84-A(12):2123–34.

    Google Scholar 

  7. Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg. 2001;83-A Suppl 1(Pt 2):S151–8.

    Google Scholar 

  8. Orive G, Gascon AR, Hernandez RM, Dominguez-Gil A, Pedraz JL. Techniques: new approaches to the delivery of biopharmaceuticals. Trends Pharmacol Sci. 2004;25(7):382–7.

    Article  PubMed  CAS  Google Scholar 

  9. Guldberg RE. Spatiotemporal delivery strategies for promoting musculoskeletal tissue regeneration. J Bone Miner Res. 2009;24(9):1507–11.

    Article  PubMed  CAS  Google Scholar 

  10. Tayalia P, Mooney DJ. Controlled growth factor delivery for tissue engineering. Adv Mater. 2009;21(32–33):3269–85.

    Article  PubMed  CAS  Google Scholar 

  11. Henry TD, Annex BH, McKendall GR, Azrin MA, Lopez JJ, Giordano FJ, et al. The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis. Circulation. 2003;107(10):1359–65.

    Article  PubMed  CAS  Google Scholar 

  12. Nutt JG, Burchiel KJ, Comella CL, Jankovic J, Lang AE, Laws ER Jr, et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology. 2003;60(1):69–73.

    Article  PubMed  CAS  Google Scholar 

  13. Ponce S, Orive G, Hernandez RM, Gascon AR, Canals JM, Munoz MT, et al. In vivo evaluation of EPO-secreting cells immobilized in different alginate-PLL microcapsules. J Control Release. 2006;116(1):28–34.

    Article  PubMed  CAS  Google Scholar 

  14. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999;14(4):529–35.

    PubMed  CAS  Google Scholar 

  15. Anitua E, Aguirre JJ, Algorta J, Ayerdi E, Cabezas AI, Orive G, et al. Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers. J Biomed Mater Res. 2008;84(2):415–21.

    Article  Google Scholar 

  16. Sanchez M, Anitua E, Orive G, Mujika I, Andia I. Platelet-rich therapies in the treatment of orthopaedic sport injuries. Sports Med. 2009;39(5):345–54.

    Article  PubMed  Google Scholar 

  17. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):638–46.

    Article  PubMed  CAS  Google Scholar 

  18. Lew WK, Weaver FA. Clinical use of topical thrombin as a surgical hemostat. Biologics. 2008;2(4):593–9.

    PubMed  CAS  Google Scholar 

  19. Anitua E, Alkhraisat MH, Orive G. Perspectives and challenges in regenerative medicine using plasma rich in growth factors. J Control Release. 2012;157(1):29–38.

    Google Scholar 

  20. Tsay RC, Vo J, Burke A, Eisig SB, Lu HH, Landesberg R. Differential growth factor retention by platelet-rich plasma composites. J Oral Maxillofac Surg. 2005;63(4):521–8.

    Article  PubMed  Google Scholar 

  21. Fufa D, Shealy B, Jacobson M, Kevy S, Murray MM. Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg. 2008;66(4):684–90.

    Article  PubMed  Google Scholar 

  22. Orive G, Zalduendo M, Anitua E. Growth factor kinetic study of PRGF-Endoret: the pioneering autologous technology in oral surgery for tissue regeneration. J Clin Periodontol. 2012;39(S13):348.

    Google Scholar 

  23. Grainger DJ, Wakefield L, Bethell HW, Farndale RW, Metcalfe JC. Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin. Nature Med. 1995;1(9):932–7.

    Article  PubMed  CAS  Google Scholar 

  24. Hakimi M, Jungbluth P, Sager M, Betsch M, Herten M, Becker J, Windolf J, Wild M. Combined use of platelet-rich plasma and autologous bone grafts in the treatment of long bone defects in mini-pigs. Injury. 2010;41(7):717–23.

    Article  PubMed  CAS  Google Scholar 

  25. Mooren RE, Merkx MA, Bronkhorst EM, Jansen JA, Stoelinga PJ. The effect of platelet-rich plasma on early and late bone healing: an experimental study in goats. Int J Oral Maxillofac Surg. 2007;36(7):626–31.

    Article  PubMed  CAS  Google Scholar 

  26. Molina-Minano F, Lopez-Jornet P, Camacho-Alonso F, Vicente-Ortega V. Plasma rich in growth factors and bone formation: a radiological and histomorphometric study in New Zealand rabbits. Braz Oral Res. 2009;23(3):275–80.

    Article  PubMed  Google Scholar 

  27. Schlegel KA, Zimmermann R, Thorwarth M, Neukam F-W, Klongnoi B, Nkenke E, et al. Sinus floor elevation using autogenous bone or bone substitute combined with platelet-rich plasma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(3):e15–25.

    Article  PubMed  Google Scholar 

  28. Trindade-Suedam IK, de Morais JA, Faeda RS, Leite FR, Tosoni GM, Neto CB, et al. Bioglass associated with leukocyte-poor platelet-rich plasma in the rabbit maxillary sinus: histomorphometric, densitometric, and fractal analysis. J Oral Implantol. 2010;36(5):333–43.

    Google Scholar 

  29. Kroese-Deutman HC, Vehof JW, Spauwen PH, Stoelinga PJ, Jansen JA. Orthotopic bone formation in titanium fiber mesh loaded with platelet-rich plasma and placed in segmental defects. Int J Oral Maxillofac Surg. 2008;37(6):542–9.

    Article  PubMed  CAS  Google Scholar 

  30. Guerra I, Morais Branco F, Vasconcelos M, Afonso A, Figueiral H, Zita R. Evaluation of implant osseointegration with different regeneration techniques in the treatment of bone defects around implants: an experimental study in a rabbit model. Clin Oral Implants Res. 2011;22(3):314–22.

    Article  PubMed  Google Scholar 

  31. Mooren RECM, Dankers ACA, Merkx MAW, Bronkhorst EM, Jansen JA, Stoelinga PJW. The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss: an experimental study in goats. Int J Oral Maxillofac Surg. 2010;39(4):371–8.

    Article  PubMed  CAS  Google Scholar 

  32. Torres J, Tamimi F, Tresguerres IF, Alkhraisat MH, Khraisat A, Blanco L, et al. Effect of combining platelet-rich plasma with anorganic bovine bone on vertical bone regeneration: early healing assessment in rabbit calvariae. Int J Oral Maxillofac Implants. 2010;25(1):123–9.

    PubMed  Google Scholar 

  33. Camarini ET, Zanoni JN, Leite PC, Boos FB. Use of biomaterials with or without platelet-rich plasma in postextraction sites: a microscopic study in dogs. Int J Oral Maxillofac Implants. 2009;24(3):432–8.

    PubMed  Google Scholar 

  34. Aghaloo TL, Moy PK, Freymiller EG. Evaluation of platelet-rich plasma in combination with anorganic bovine bone in the rabbit cranium: a pilot study. Int J Oral Maxillofac Implants. 2004;19(1):59–65.

    PubMed  Google Scholar 

  35. Wiltfang J, Kloss FR, Kessler P, Nkenke E, Schultze-Mosgau S, Zimmermann R, Schlegel KA. Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects: an animal experiment. Clin Oral Implants Res. 2004;15(2):187–93.

    Article  PubMed  Google Scholar 

  36. Sugimori E, Shintani S, Ishikawa K, Hamakawa H. Effects of apatite foam combined with platelet-rich plasma on regeneration of bone defects. Dent Mater J. 2006;25(3):591–6.

    Article  PubMed  CAS  Google Scholar 

  37. Intini G, Andreana S, Intini FE, Buhite RJ, Bobek LA. Calcium sulfate and platelet-rich plasma make a novel osteoinductive biomaterial for bone regeneration. J Transl Med. 2007;5:13.

    Article  PubMed  Google Scholar 

  38. Shi B, Zhou Y, Wang YN, Cheng XR. Alveolar ridge preservation prior to implant placement with surgical-grade calcium sulfate and platelet-rich plasma: a pilot study in a canine model. Int J Oral Maxillofac Implants. 2007;22(4):656–65.

    PubMed  Google Scholar 

  39. Nair MB, Varma HK, Menon KV, Shenoy SJ, John A. Reconstruction of goat femur segmental defects using triphasic ceramic-coated hydroxyapatite in combination with autologous cells and platelet-rich plasma. Acta Biomater. 2009;5(5):1742–55.

    Article  PubMed  CAS  Google Scholar 

  40. Plachokova AS, van den Dolder J, van den Beucken JJ, Jansen JA. Bone regenerative properties of rat, goat and human platelet-rich plasma. Int J Oral Maxillofac Surg. 2009;38(8):861–9.

    Article  PubMed  CAS  Google Scholar 

  41. Kim B-K, Kim S-G, Kim S-Y, Lim S-C, Kim Y-K. A comparison of bone generation capability in rabbits using tooth ash and plaster of Paris with platelet-rich plasma or fibrin sealant. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(3):e8–14.

    Article  PubMed  Google Scholar 

  42. Suba Z, Takács D, Gyulai-Gaál S, Kovács K. Facilitation of beta-tricalcium phosphate-induced alveolar bone regeneration by platelet-rich plasma in beagle dogs: a histologic and histomorphometric study. Int J Oral Maxillofac Implants. 2004;19(6):832–8.

    PubMed  Google Scholar 

  43. Nagae M, Ikeda T, Mikami Y, Hase H, Ozawa H, Matsuda K, et al. Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres. Tissue Eng. 2007;13(1):147–58.

    Article  PubMed  CAS  Google Scholar 

  44. Kurita J, Miyamoto M, Ishii Y, Aoyama J, Takagi G, Naito Z, et al. Enhanced vascularization by controlled release of platelet-rich plasma impregnated in biodegradable gelatin hydrogel. Ann Thorac Surg. 2011;92(3):837–44.

    Article  PubMed  Google Scholar 

  45. Bi L, Cheng W, Fan H, Pei G. Reconstruction of goat tibial defects using an injectable tricalcium phosphate/chitosan in combination with autologous platelet-rich plasma. Biomaterials. 2010;31(12):3201–11.

    Article  PubMed  CAS  Google Scholar 

  46. Rai B, Ho KH, Lei Y, Si-Hoe KM, Jeremy Teo CM, Yacob KB, et al. Polycaprolactone-20 % tricalcium phosphate scaffolds in combination with platelet-rich plasma for the treatment of critical-sized defects of the mandible: a pilot study. J Oral Maxillofac Surg. 2007;65(11):2195–205.

    Google Scholar 

  47. Kasten P, Vogel J, Luginbuhl R, Niemeyer P, Weiss S, Schneider S, et al. Influence of platelet-rich plasma on osteogenic differentiation of mesenchymal stem cells and ectopic bone formation in calcium phosphate ceramics. Cells Tissues Organs. 2006;183(2):68–79.

    Article  PubMed  CAS  Google Scholar 

  48. Pieri F, Lucarelli E, Corinaldesi G, Fini M, Aldini NN, Giardino R, Donati D, Marchetti C. Effect of mesenchymal stem cells and platelet-rich plasma on the healing of standardized bone defects in the alveolar ridge: a comparative histomorphometric study in minipigs. J Oral Maxillofac Surg. 2009;67(2):265–72.

    Article  PubMed  Google Scholar 

  49. Behnia H, Khojasteh A, Kiani MT, Khoshzaban A, Abbas FM, Bashtar M, et al. Bone regeneration with a combination of nanocrystalline hydroxyapatite silica gel, platelet-rich growth factor, and mesenchymal stem cells: a histologic study in rabbit calvaria. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012. doi:10.1016/j.oooo.2011.09.034.

  50. Metzler P, von Wilmowsky C, Zimmermann R, Wiltfang J, Schlegel KA. The effect of current used bone substitution materials and platelet-rich plasma on periosteal cells by ectopic site implantation: an in-vivo pilot study. J Craniomaxillofac Surg. 2012;40(5):409–15.

    Article  PubMed  Google Scholar 

  51. Weibrich G, Hansen T, Kleis W, Buch R, Hitzler WE. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone. 2004;34(4):665–71.

    Article  PubMed  CAS  Google Scholar 

  52. Intini G. The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials. 2009;30(28):4956–66.

    Article  PubMed  CAS  Google Scholar 

  53. Plachokova AS, Nikolidakis D, Mulder J, Jansen JA, Creugers NH. Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review. Clin Oral Implants Res. 2008;19(6):539–45.

    Article  PubMed  Google Scholar 

  54. Anitua E, Sánchez M, Nurden AT, Nurden P, Orive G, Andía I. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006;24(5):227–34.

    Article  PubMed  CAS  Google Scholar 

  55. Anitua E, Sánchez M, Orive G, Andía I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007;28(31):4551–60.

    Article  PubMed  CAS  Google Scholar 

  56. Anitua E, Andia Ortiz I. BTI implant system: the first implant system with a bioactive surface. Maxillaris. 2001;39:2–7.

    Google Scholar 

  57. Anitua EA. Enhancement of osseointegration by generating a dynamic implant surface. J Oral Implantol. 2006;32(2):72–6.

    Article  PubMed  Google Scholar 

  58. Anitua E, Orive G, Aguirre JJ, Ardanza B, Andia I. 5-year clinical experience with BTI dental implants: risk factors for implant failure. J Clin Periodontol. 2008;35(8):724–32.

    Article  PubMed  Google Scholar 

  59. Tozum TF, Demiralp B. Platelet-rich plasma: a promising innovation in dentistry. J Can Dent Assoc. 2003;69(10):664.

    PubMed  Google Scholar 

  60. Chaput CD, Patel KV, Brindley GW, Roux MA, Hu N, Dmitriev A, et al. Influence of a platelet concentrate on prosthetic bone ingrowth in a rabbit model. J Surg Orthop Adv. 2007 Winter;16(4):159–63.

  61. Thor A, Rasmusson L, Wennerberg A, Thomsen P, Hirsch JM, Nilsson B, et al. The role of whole blood in thrombin generation in contact with various titanium surfaces. Biomaterials. 2007;28(6):966–74.

    Article  PubMed  CAS  Google Scholar 

  62. Schmaier AH. Contact activation: a revision. Thromb Haemost. 1997;78(1):101–7.

    PubMed  CAS  Google Scholar 

  63. Ellingsen JE. A study on the mechanism of protein adsorption to TiO2. Biomaterials. 1991;12(6):593–6.

    Article  PubMed  CAS  Google Scholar 

  64. Evans-Nguyen KM, Schoenfisch MH. Fibrin proliferation at model surfaces: influence of surface properties. Langmuir. 2005;21(5):1691–4.

    Article  PubMed  CAS  Google Scholar 

  65. Cucuianu M, Trif I. The role of platelets and leukocytes in coagulation and fibrinolysis. Rev Roum Physiol. 1992;29(1–2):33–8.

    PubMed  CAS  Google Scholar 

  66. Nikolidakis D, van den Dolder J, Wolke JG, Jansen JA. Effect of platelet-rich plasma on the early bone formation around Ca–P-coated and non-coated oral implants in cortical bone. Clin Oral Implants Res. 2008;19(2):207–13.

    Article  PubMed  Google Scholar 

  67. Kanagaraja S, Lundstrom I, Nygren H, Tengvall P. Platelet binding and protein adsorption to titanium and gold after short time exposure to heparinized plasma and whole blood. Biomaterials. 1996;17(23):2225–32.

    Article  PubMed  CAS  Google Scholar 

  68. Anitua E, Orive G, Pla R, Roman P, Serrano V, Andia I. The effects of PRGF on bone regeneration and on titanium implant osseointegration in goats: a histologic and histomorphometric study. J Biomed Mater Res. 2009;91(1):158–65.

    Article  Google Scholar 

  69. Fontana S, Olmedo DG, Linares JA, Guglielmotti MB, Crosa ME. Effect of platelet-rich plasma on the peri-implant bone response: an experimental study. Implant Dent. 2004;13(1):73–8.

    Article  PubMed  Google Scholar 

  70. Fuerst G, Gruber R, Tangl S, Sanroman F, Watzek G. Enhanced bone-to-implant contact by platelet-released growth factors in mandibular cortical bone: a histomorphometric study in minipigs. Int J Oral Maxillofac Implants. 2003;18(5):685–90.

    PubMed  Google Scholar 

  71. de Vasconcelos Gurgel BC, Goncalves PF, Pimentel SP, Ambrosano GM, Nociti Junior FH, Sallum EA, et al. Platelet-rich plasma may not provide any additional effect when associated with guided bone regeneration around dental implants in dogs. Clin Oral Implants Res. 2007;18(5):649–54.

  72. Garcia RV, Gabrielli MA, Hochuli-Vieira E, Spolidorio LC, Filho JG, Neto FA, et al. Effect of platelet-rich plasma on peri-implant bone repair: a histologic study in dogs. J Oral Implantol. 2010;36(4):281–90.

    Article  PubMed  Google Scholar 

  73. Schlegel KA, Kloss FR, Kessler P, Schultze-Mosgau S, Nkenke E, Wiltfang J. Bone conditioning to enhance implant osseointegration: an experimental study in pigs. Int J Oral Maxillofac Implants. 2003;18(4):505–11.

    PubMed  Google Scholar 

  74. Zechner W, Tangl S, Tepper G, Furst G, Bernhart T, Haas R, et al. Influence of platelet-rich plasma on osseous healing of dental implants: a histologic and histomorphometric study in minipigs. Int J Oral Maxillofac Implants. 2003;18(1):15–22.

    Google Scholar 

  75. Jensen TB, Bechtold JE, Chen X, Vestermark M, Soballe K. No effect of autologous growth factors (AGF) around ungrafted loaded implants in dogs. Int Orthop. 2010;34(6):925–30.

    Article  PubMed  Google Scholar 

  76. Eriksson C, Lausmaa J, Nygren H. Interactions between human whole blood and modified TiO2-surfaces: influence of surface topography and oxide thickness on leukocyte adhesion and activation. Biomaterials. 2001;22(14):1987–96.

    Article  PubMed  CAS  Google Scholar 

  77. Vogler EA, Siedlecki CA. Contact activation of blood-plasma coagulation. Biomaterials. 2009;30(10):1857–69.

    Article  PubMed  CAS  Google Scholar 

  78. Kammerer PW, Gabriel M, Al-Nawas B, Scholz T, Kirchmaier CM, Klein MO. Early implant healing: promotion of platelet activation and cytokine release by topographical, chemical and biomimetical titanium surface modifications in vitro. Clin Oral Implants Res. 2012;23(4):504–10.

    Article  PubMed  CAS  Google Scholar 

  79. Park JY, Gemmell CH, Davies JE. Platelet interactions with titanium: modulation of platelet activity by surface topography. Biomaterials. 2001;22(19):2671–82.

    Article  PubMed  CAS  Google Scholar 

  80. Rajtar G, Livio M, Merino J, de Gaetano G. Malondialdehyde formation in rat platelet-rich plasma: I. A kinetic approach. Thromb Haemost. 1980;44(2):49–51.

    PubMed  CAS  Google Scholar 

  81. Kasten P, Vogel J, Beyen I, Weiss S, Niemeyer P, Leo A, et al. Effect of platelet-rich plasma on the in vitro proliferation and osteogenic differentiation of human mesenchymal stem cells on distinct calcium phosphate scaffolds: the specific surface area makes a difference. J Biomater Appl. 2008;23(2):169–88.

    Article  PubMed  CAS  Google Scholar 

  82. Clemmons RM, Bliss EL, Dorsey-Lee MR, Seachord CL, Meyers KM. Platelet function, size and yield in whole blood and in platelet-rich plasma prepared using differing centrifugation force and time in domestic and food-producing animals. Thromb Haemost. 1983;50(4):838–43.

    PubMed  CAS  Google Scholar 

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Acknowledgments

No sources of funding were used to prepare this manuscript. The authors are researchers at BTI Biotechnology Institute I + D (Vitoria, Spain).

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Authors and Affiliations

  1. Private Practice in Implantology and Oral Rehabilitation, Vitoria, Spain

    Eduardo Anitua

  2. BTI Biotechnology Institute, Vitoria, Spain

    Eduardo Anitua, Ricardo Tejero, Mohammad H. Alkhraisat & Gorka Orive

  3. NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country, Vitoria-Gasteiz, Spain

    Gorka Orive

  4. Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Vitoria-Gasteiz, Spain

    Gorka Orive

  5. Instituto Eduardo Anitua, c/ Jose Maria Cajigal 19, 10005, Vitoria, Spain

    Gorka Orive

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  1. Eduardo Anitua
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  2. Ricardo Tejero
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  3. Mohammad H. Alkhraisat
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  4. Gorka Orive
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Correspondence to Gorka Orive.

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Anitua, E., Tejero, R., Alkhraisat, M.H. et al. Platelet-Rich Plasma to Improve the Bio-Functionality of Biomaterials. BioDrugs 27, 97–111 (2013). https://doi.org/10.1007/s40259-012-0004-3

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