In Silico Pharmacology

, 5:3

Revealing the potency of Annona muricata leaves extract as FOXO1 inhibitor for diabetes mellitus treatment through computational study

  • Dini Sri Damayanti
  • Didik Huswo Utomo
  • Chandra Kusuma
Original Research

Abstract

FOXO1 protein inactivation in the nucleus is one of targets for the treatment of diabetes mellitus. Annona muricata leaves contain flavonoid and phenolic compound alkaloids that were known to be able to increase pancreatic β cell proliferation in animal experiment. This research aimed to predict the active compound ability of the Annona muricata leaves to bind and inhibit FOXO1 protein through in silico study. Analysis of molecular docking was performed by using Autodock Vina PyRx. this research proved that anonaine, rutin, muricatocin a, isolaureline, xylopine, and kaempferol 3-O-rutinoside had an equal or smaller free binding energy compared to the control compound. Rutin and Muricatocin A had the same binding ability toward 66% amino acid residues, compared to control compound with hydrogen bond type, while xylopine, anonaine, isolaureline, kaempferol 3-O-rutinoside had a similar binding ability towards 33% amino acid residues compared to control compound with hydrogen bond type.

Keywords

Anonaine Active compound Annona muricata leaves FOXO1 In silico Isolaureline Kaempferol 3-O-rutinoside Muricatocin A Rutin Xylopine 

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Dini Sri Damayanti
    • 1
  • Didik Huswo Utomo
    • 2
  • Chandra Kusuma
    • 1
  1. 1.Faculty of MedicineBrawijaya UniversityMalangIndonesia
  2. 2.Department of Biology, Faculty of Mathematics and Natural SciencesBrawijaya UniversityMalangIndonesia

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