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•• Parra A, Madrid R, Echevarria D, delOlmo S, Morenilla-Palao C, Acosta MC, Gallar J, Dhaka A, Viana F, Belmonte C. Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. Nat Med. 2010;16:1396–9. The first demonstration that cold thermoreceptors of the cornea depend on the expression of the TRPM8 channel for spontaneous and cold evoked responses and of the role of cold thermoreceptors in the maintaining of basal tearing in rodents and humans.
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Latorre R, Brauchi S, Madrid R, Orio P. A cool channel in cold transduction. Physiology. 2011;26:273–85.
•• Parra A, Gonzalez O, Gallar J, Belmonte C. Tear film hyperosmolality increases nerve impulse activity of cold thermoreceptor endings of the cornea. Pain. 2014;155:1481–91. First experimental demonstration that hyperosmolality in tears excites corneal cold thermoreceptors, proposing a mechanism for the contribution of corneal cold thermoreceptors in dry eye.
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Morenilla-Palao C, Luis E, Fernández-Peña C, Quintero E, Weaver JL, Bayliss DA, Viana F. Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation. Cell Rep. 2014;8:1571–82.
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•• Gallar J, Acosta MC, Moilanen JAO, Holopainen JM, Belmonte C, Tervo T. Recovery of corneal sensitivity to mechanical and chemical stimulation after laser in situ keratomileusis. J Refract Surg. 2004;20:229–35. First demonstration in humans of the reduction of corneal sensitivity for all sensory modalities after photorefractive surgery.
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Namavari A, Chaudhary S, Chang JH, Yco L, Sonawane S, Khanolkar V, Yue BY, Sarkar J, Jain S. Cyclosporine immunomodulation retards regeneration of surgically transected corneal nerves. Invest Ophthalmol Vis Sci. 2012;53:732–40.
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Acosta MC, Luna CL, Quirce S, Belmonte C, Gallar J. Changes in sensory activity of ocular surface sensory nerves during allergic keratoconjunctivitis. Pain. 2013;154:2353–62.
Acosta MC, Luna C, Quirce S, Belmonte C, Gallar J. Corneal sensory nerve activity in an experimental model of UV keratitis. Invest Ophthalmol Vis Sci. 2014;55:3403–12.
Report of the Dry Eye Workshop. Ocul Surf. 2007;5:65–204.
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Descoeur J, Pereira V, Pizzoccaro A, Francois A, Ling B, Maffre V, Couette B, Busserolles J, Courteix C, Noel J, Lazdunski M, Eschalier A, Authier N, Bourinet E. Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med. 2011;3:266–78.
Belmonte C, Gallar J. Cold thermoreceptors, unexpected players in tear production and ocular dryness sensations. Invest Ophthalmol Vis Sci. 2011;52:3888–92.
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Stern ME, Schaumburg CS, Pflugfelder SC. Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013;32:19–41.
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•• Belmonte C. Eye dryness sensations after refractive surgery. Impaired tear secretion or ‘phantom’ cornea? J Refract Surg. 2007;23:598–602. First proposal that dryness sensations experienced by dry eye patients are due to neuropathic ocular pain and not ocular surface dryness.
•• Stapleton F, Marfurt C, Golebiowski B, Rosenblatt M, Bereiter D, Begley C, Dartt D, Gallar J, Belmonte C, Hamrah P, Willcox M. The TFOS international workshop on contact lens discomfort: report of the subcommittee on neurobiology. Invest Ophthalmol Vis Sci. 2013;54:TFOS71–97. A complete and updated revision of ocular surface pain.