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An efficient transformation of methyl ethers and nitriles to amides catalyzed by Iron(III) perchlorate hydrate

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Abstract

An efficient and inexpensive synthesis of N-substituted amides from the reaction of nitriles with methyl ethers catalyzed by Fe(ClO4)3·H2O is described. Fe(ClO4)3·H2O is an economically efficient catalyst for the Ritter Reaction under solvent-free conditions. A range of methyl ethers (benzyl, sec-alkyl and tert-butyl ethers) were reacted with nitriles to provide the corresponding amides in high–excellent yields.

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Acknowledgements

We are grateful to Nantong City Science Foundation (No. 2015) and Science program of Jiangsu College of Engineering and Technology for financial support.

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Authors and Affiliations

  1. Institute of Pharmaceutical Engineering, Jiangsu College of Engineering and Technology, Nantong, 226000, Jiangsu, People’s Republic of China

    Guibo Yin & Bin Yan

  2. School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, 211189, Jiangsu, People’s Republic of China

    Junqing Chen & Min Ji

Authors
  1. Guibo Yin
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  2. Bin Yan
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  3. Junqing Chen
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  4. Min Ji
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Correspondence to Guibo Yin.

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Yin, G., Yan, B., Chen, J. et al. An efficient transformation of methyl ethers and nitriles to amides catalyzed by Iron(III) perchlorate hydrate. J IRAN CHEM SOC 16, 1355–1363 (2019). https://doi.org/10.1007/s13738-019-01615-4

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  • DOI: https://doi.org/10.1007/s13738-019-01615-4

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