Abstract
Patients with cholangiocarcinoma sometimes show very slow progression and thereby exhibit long-term survival under treatment of the disease. A 72-year-old male with hilar cholangiocarcinoma underwent extended-right hemi-hepatectomy and caudate lobectomy. Pathological finding revealed a well differentiated tumor and carcinoma in situ at the bile duct margin. Routine imaging follow-up was continued for 5 years. Ten years after the surgery, the patient noticed a right-hand chest wall mass formation of 5 cm without any symptoms, and the tumor was diagnosed metastatic cholangiocarcinoma by needle biopsy. Radical resection of the metastatic tumor was performed. The pathological findings of the primary tumor and the metastatic tumor were similar. Three months later, recurrent multiple lesions were identified in the chest wall and the liver. The patient received chemotherapy. We here report a rare case of metastatic cholangiocarcinoma 10 years after hepatectomy with positive ductal margin of carcinoma in situ, implying that rare event of very late recurrence of patients with hilar cholangiocarcinoma should be taken into consideration.
Similar content being viewed by others
References
DeOliveira ML, Cunningham SC, Cameron JL et al (2007) Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg 245:755–762
Okabe H, Hashimoto D, Chikamoto A et al (2015) Hepatobiliary and Pancreatic: Skin metastases from cholangiocarcinoma mimicking herpes zoster. J Gastroenterol Hepatol 30:1337
Miyata T, Okabe H, Chikamoto A et al (2017) A long-term survivor of hilar cholangiocarcinoma with resection of recurrent peritoneal dissemination after R0 surgery: a case report. Surg Case Rep 3:110
Nagino M, Ebata T, Yokoyama Y et al (2013) Evolution of surgical treatment for perihilar cholangiocarcinoma: a single-center 34-year review of 574 consecutive resections. Ann Surg 258:129–140
Lee SG, Song GW, Hwang S et al (2010) Surgical treatment of hilar cholangiocarcinoma in the new era: the Asan experience. J Hepatobiliary Pancreat Sci 17:476–489
Unno M, Katayose Y, Rikiyama T et al (2010) Major hepatectomy for perihilar cholangiocarcinoma. J Hepatobiliary Pancreat Sci 17:463–469
Tanaka N, Nobori M, Kohzuma T et al (1994) Anastomotic recurrence at hepaticojejunostomy in a long-term survivor of bile duct carcinoma: report of a case. Surg Today 24:280–284
Sasaki T, Kondo S, Ambo Y et al (2006) Local recurrence at hepaticojejunostomy 9 years after resection of bile duct cancer with superficial flat spread. J Hepatobiliary Pancreat Sci 13:458–462
Machimoto T, Doi R, Ogawa K et al (2009) Abdominal wall recurrence of Hilar bile duct cancer 12 years after a curative resection: report of a case. Surg Today 39:72–76
Ota Y, Matsuyama R, Taniguchi K et al (2013) Solitary rib recurrence of hilar cholangiocarcinoma 10 years after resection: report of a case. Clin J Gastroenterol 6:485–489
Buchner D, Drebber U, Chang DH et al (2016) Bile duct carcinoma recurrence in the papillary region in a long-term survivor of hilar cholangiocarcinoma: a case report. J Med Case Rep 10:299
Kitano Y, Yamashita YI, Nakagawa S et al (2019) Effectiveness of surgery for recurrent cholangiocarcinoma: a single center experience and brief literature review. Am J Surg 219:175–180
Igami T, Nagino M, Oda K et al (2009) Clinicopathologic study of cholangiocarcinoma with superficial spread. Ann Surg 249:296–302
Primrose JN, Fox RP, Palmer DH et al (2019) Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study. Lancet Oncol 20:663–673
Furuse J, Okusaka T, Boku N et al (2008) S-1 monotherapy as first-line treatment in patients with advanced biliary tract cancer: a multicenter phase II study. Cancer Chemother Pharmacol 62:849–855
Kobayashi S, Nagano H, Tomokuni A et al (2019) a prospective, randomized phase II study of adjuvant gemcitabine versus s-1 after major hepatectomy for biliary tract cancer (KHBO 1208): Kansai Hepato-biliary oncology group. Ann Surg 270:230–237
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors have no conflicts of interest.
Ethical approval
It was deemed to be unnecessary for this report.
Informed consent
It was obtained from the patient and family according to the institutional review board protocols.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Mitsuura, C., Okabe, H., Yamashita, Yi. et al. A case of chest wall recurrence of hilar cholangiocarcinoma 10 years after R1 surgery with positive ductal margin of carcinoma in situ. Int Canc Conf J 9, 77–81 (2020). https://doi.org/10.1007/s13691-020-00400-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13691-020-00400-y