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Natural Products and Bioprospecting

, Volume 3, Issue 6, pp 277–281 | Cite as

New amide alkaloids from Piper longum fruits

  • Jun Yang
  • Yao Su
  • Ji-Feng Luo
  • Wei Gu
  • Hong-Mei Niu
  • Yan Li
  • Yue-Hu Wang
  • Chun-Lin Long
Open Access
Regular Article

Abstract

Three new amide alkaloids piperlongumamides A-C (1–3), together with 12 known ones (4–15), were isolated from the fruits of Piper longum. The structures of the new isolates were determined using spectroscopic data analyses. Cytotoxic activity of these amides against HL-60 (human leukemia), A-549 (human lung cancer), MCF-7 (human breast cancer), SMMC-7721 (human liver cancer) and SW480 (human rectal cancer) cell lines were evaluated. Piperchabamide B (11) exhibited weak inhibitory activity against HL-60 (IC50 = 21.32 μM ), A-549 (IC50 = 23.82 μM ) and MCF-7 (IC50 = 16.58 μM ) cell lines.

Keywords

Piperaceae Piper longum amide alkaloids piperlongumamides piperchabamide B cytotoxicity 

Supplementary material

13659_2013_73_MOESM1_ESM.pdf (2 mb)
Supplementary material, approximately 1.95 MB.

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Copyright information

© The Author(s) 2013

This article is published under license to BioMed Central Ltd. Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

Authors and Affiliations

  1. 1.Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of BotanyChinese Academy of SciencesKunmingChina
  2. 2.College of Resources and Environmental SciencesHebei Agricultural UniversityHebeiChina
  3. 3.State Key Laboratory of Phytochemisty and Plant Resources in West China, Kunming Institute of BotanyChinese Academy of SciencesKunmingChina
  4. 4.College of Life and Environmental SciencesMinzu University of ChinaBeijingChina

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