Oriental Pharmacy and Experimental Medicine

, Volume 12, Issue 2, pp 107–111 | Cite as

Mori Folium regulates DSS-induced ulcerative colitis in mice and cytokine production in mast cells

  • In-Young Choi
  • You-Jeong Kim
  • Ji-Ye Kee
  • Min-Chol Kim
  • Dong-Jin Lee
  • Sung-One Cho
  • Jang-Ho Ko
  • Dae-Seung Kim
  • Yong-Deok Jeon
  • Cheol-Hee Yoon
  • Yun-Jum Park
  • Jae-Young Um
  • Seung-Heon Hong
Research Article
  • 201 Downloads

Abstract

Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut, and the imbalance between proinflammatory and anti-inflammatory reactivity. The incidence and prevalence rates of IBD in Korea have been increasing rapidly during the past decades. In this study, we investigated regulatory effect of leaf of a mulberry tree (Moraceae) called Gwasang-No.2 in Korea. Leaf of Gwasang-No.2 (Gwa.L) inhibited the inflammatory responses on dextran sulfate sodium induced ulcerative colitis in mice and the production of nitrite oxide from lipopolysaccharide and interferon-gamma stimulated mouse peritoneal macrophages. Gwa.L inhibited IL-6 and IL-8 production from HMC-1 cells without cytotoxic effects on cell viability. These results may be relevant for future pharmacological or dietary interventions in patients with ulcerative colitis.

Keywords

Mulberry leaf Ulcerative colitis DSS Nitrite oxide Anti-inflammation 

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Copyright information

© Institute of Oriental Medicine, Kyung Hee University 2012

Authors and Affiliations

  • In-Young Choi
    • 1
  • You-Jeong Kim
    • 1
  • Ji-Ye Kee
    • 1
  • Min-Chol Kim
    • 1
  • Dong-Jin Lee
    • 1
  • Sung-One Cho
    • 1
  • Jang-Ho Ko
    • 1
  • Dae-Seung Kim
    • 1
  • Yong-Deok Jeon
    • 1
  • Cheol-Hee Yoon
    • 1
  • Yun-Jum Park
    • 2
  • Jae-Young Um
    • 3
  • Seung-Heon Hong
    • 1
  1. 1.Department of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research InstituteWonkwang UniversityIksanRepublic of Korea
  2. 2.Division of Horticulture and Pet Animal-Plant ScienceWonkwang UniversityIksanRepublic of Korea
  3. 3.College of Oriental MedicineKyung Hee UniversitySeoulRepublic of Korea

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