Jemec GB. Hidradenitis suppurativa. NEJM. 2012;366(2):158–64.
CAS
PubMed
Google Scholar
Jahns AC, Killasli H, Nosek D, et al. Microbiology of hidradenitis suppurativa (acne inversa): a histological study of 27 patients. APMIS. 2014;122(9):804–9.
PubMed
Google Scholar
Sabat R, Jemec GBE, Matusiak Ł, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nat Rev Dis Prim. 2020;6(1):18.
PubMed
Google Scholar
Saunte D, Boer J, Stratigos A, et al. Diagnostic delay in hidradenitis suppurativa is a global problem. Br J Dermatol. 2015;173(6):1546–9.
CAS
PubMed
Google Scholar
Shlyankevich J, Chen AJ, Kim GE, Kimball AB. Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: a chart-verified case-control analysis. J Am Acad Dermatol. 2014;71(6):1144–50.
PubMed
Google Scholar
Phan K, Charlton O, Smith SD. Hidradenitis suppurativa and polycystic ovarian syndrome: systematic review and meta-analysis. Austral J Dermatol. 2020;61(1):e28–33.
Google Scholar
Kromann CB, Ibler KS, Kristiansen VB, Jemec GB. The influence of body weight on the prevalence and severity of hidradenitis suppurativa. Acta Derm Venereol. 2014;94(5):553–7.
PubMed
Google Scholar
Sartorius K, Emtestam L, Jemec G, Lapins J. Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity. Br J Dermatol. 2009;161(4):831–9.
CAS
Google Scholar
Phan K, Charlton O, Smith S. Hidradenitis suppurativa and diabetes mellitus: updated systematic review and adjusted meta-analysis. Clin Exp Dermatol. 2019;44(4):e126–32.
CAS
PubMed
Google Scholar
Miller IM, Ellervik C, Vinding GR, et al. Association of metabolic syndrome and hidradenitis suppurativa. JAMA Dermatol. 2014;150(12):1273–80.
PubMed
Google Scholar
Napolitano M, Megna M, Timoshchuk EA, et al. Hidradenitis suppurativa: from pathogenesis to diagnosis and treatment. Clin Cosmet Investig Dermatol. 2017;10:105.
CAS
PubMed
PubMed Central
Google Scholar
Scuderi N, Monfrecola A, Dessy LA, Fabbrocini G, Megna M, Monfrecola G. Medical and surgical treatment of hidradenitis suppurativa: a review. Skin Append Disord. 2017;3(2):95–110.
Google Scholar
Balato A, Cacciapuoti S, Di Caprio R, et al. Human microbiome: composition and role in inflammatory skin diseases. Arch Immunol Ther Exp. 2019;67(1):1–18.
Google Scholar
Nakatsuji T, Chiang H-I, Jiang SB, Nagarajan H, Zengler K, Gallo RL. The microbiome extends to subepidermal compartments of normal skin. Nat Commun. 2013;4(1):1–8.
Google Scholar
Polkowska-Pruszyńska B, Gerkowicz A, Krasowska D. The gut microbiome alterations in allergic and inflammatory skin diseases—an update. J Eur Acad Dermatol Venereol. 2020;34(3):455–64.
PubMed
Google Scholar
Prescott SL, Larcombe D-L, Logan AC, et al. The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming. World Allergy Org J. 2017;10(1):1–16.
Google Scholar
Levy M, Kolodziejczyk AA, Thaiss CA, Elinav E. Dysbiosis and the immune system. Nat Rev Immunol. 2017;17(4):219–32.
CAS
Google Scholar
Lynch SV, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med. 2016;375(24):2369–79.
CAS
PubMed
Google Scholar
Macklis P, Adams K, Kaffenberger J, Kumar P, Krispinsky A, Kaffenberger B. The association between oral health and skin disease. J Clin Aesthet Dermatol. 2020;13(6):48–53.
Vekic DA, Cains GD. Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 2. Austral J Dermatol. 2018;59(4):261–6.
Riverain-Gillet É, Guet-Revillet H, Jais J-P, et al. The surface microbiome of clinically unaffected skinfolds in hidradenitis suppurativa: a cross-sectional culture based and 16S rRNA gene amplicon sequencing study in 60 patients. J Investig Dermatol. 2020;140(9):1847–55.e6.
Naik HB, Jo J-H, Paul M, Kong HH. Skin microbiota perturbations are distinct and disease severity-dependent in hidradenitis suppurativa. J Investig Dermatol. 2019;140(4):922–5.e3.
Ring H, Sigsgaard V, Thorsen J, et al. The microbiome of tunnels in hidradenitis suppurativa patients. J Eur Acad Dermatol Venereol. 2019;33(9):1775–80.
CAS
PubMed
Google Scholar
Guet-Revillet H, Jais J-P, Ungeheuer M-N, et al. The microbiological landscape of anaerobic infections in hidradenitis suppurativa: a prospective metagenomic study. Clin Infect Dis. 2017;65(2):282–91.
CAS
PubMed
Google Scholar
Ring HC, Thorsen J, Saunte DM, et al. The follicular skin microbiome in patients with hidradenitis suppurativa and healthy controls. JAMA Dermatol. 2017;153(9):897–905.
PubMed
PubMed Central
Google Scholar
Guet-Revillet H, Coignard-Biehler H, Jais J-P, et al. Bacterial pathogens associated with hidradenitis suppurativa, France. Emerg Infect Dis. 2014;20(12):1990.
CAS
PubMed
PubMed Central
Google Scholar
Benzecry V, Grancini A, Guanziroli E, et al. Hidradenitis suppurativa/acne inversa: a prospective bacteriological study of 46 patients and review of the literature. G Ital Dermatol Venereol. 2020;155(4):459–63.
Bettoli V, Manfredini M, Massoli L, et al. Rates of antibiotic resistance/sensitivity in bacterial cultures of hidradenitis suppurativa patients. J Eur Acad Dermatol Venereol. 2019;33(5):930–6.
CAS
PubMed
Google Scholar
Jamalpour M, Saki N, Nozari F. Microbial profile and antibiotic susceptibility of bacteria isolated from patients with hidradenitis suppurativa. Iran J Dermatol. 2019;22(1):25–9.
Google Scholar
Nikolakis G, Liakou AI, Bonovas S, et al. Bacterial colonization in hidradenitis suppurativa/acne inversa: a cross-sectional study of 50 patients and review of the literature. Acta Derm Venereol. 2017;97(4):493–8.
CAS
PubMed
Google Scholar
Thomas C, Rodby KA, Thomas J, Shay E, Antony AK. Recalcitrant hidradenitis suppurativa: an investigation of demographics, surgical management, bacterial isolates, pharmacologic intervention, and patient-reported health outcomes. Am Surg. 2016;82(4):362–8.
PubMed
Google Scholar
Hessam S, Sand M, Georgas D, Anders A, Bechara FG. Microbial profile and antimicrobial susceptibility of bacteria found in inflammatory hidradenitis suppurativa lesions. Skin Pharmacol Physiol. 2016;29(3):161–7.
CAS
PubMed
Google Scholar
Katoulis AC, Koumaki D, Liakou AI, et al. Aerobic and anaerobic bacteriology of hidradenitis suppurativa: a study of 22 cases. Skin Append Disord. 2015;1(2):55–9.
Google Scholar
Matusiak U, Bieniek A, Szepietowski JC. Bacteriology of hidradenitis suppurativa–which antibiotics are the treatment of choice? Acta Derm Venereol. 2014;94(6):699–702.
PubMed
Google Scholar
Sartorius K, Killasli H, Oprica C, Sullivan A, Lapins J. Bacteriology of hidradenitis suppurativa exacerbations and deep tissue cultures obtained during carbon dioxide laser treatment. Br J Dermatol. 2012;166(4):879–83.
CAS
PubMed
Google Scholar
Lapins J, Jarstrand C, Emtestam L. Coagulase-negative staphylococci are the most common bacteria found in cultures from the deep portions of hidradenitis suppurativa lesions, as obtained by carbon dioxide laser surgery. Br J Dermatol. 1999;140(1):90.
CAS
PubMed
Google Scholar
Brook I, Frazier EH. Aerobic and anaerobic microbiology of axillary hidradenitis suppurativa. J Med Microbiol. 1999;48(1):103–5.
CAS
PubMed
Google Scholar
Jemec G, Faber M, Gutschik E, Wendelboe P. The bacteriology of hidradenitis suppurativa. Dermatology. 1996;193(3):203–6.
CAS
PubMed
Google Scholar
Highet AS, Warren RE, Weekes AJ. Bacteriology and antibiotic treatment of perineal suppurative hidradenitis. Arch Dermatol. 1988;124(7):1047–51.
CAS
PubMed
Google Scholar
Kam S, Collard M, Lam J, Alani RM. Gut microbiome perturbations in patients with hidradenitis suppurativa: a case series. J Investig Dermatol. 2020. https://doi.org/10.1016/j.jid.2020.04.017.
Eppinga H, Sperna Weiland CJ, Thio HB, et al. Similar depletion of protective Faecalibacterium prausnitzii in psoriasis and inflammatory bowel disease, but not in hidradenitis suppurativa. J Crohns Colitis. 2016;10(9):1067–75.
PubMed
Google Scholar
Falagas ME, Siakavellas E. Bacteroides, Prevotella, and Porphyromonas species: a review of antibiotic resistance and therapeutic options. Int J Antimicrob Agents. 2000;15(1):1–9.
CAS
PubMed
Google Scholar
Lousada M, Lachnit T, Edelkamp J, et al. Exploring the human hair follicle microbiome. Br J Dermatol. 2020. https://doi.org/10.1111/bjd.19461.
Mysak J, Podzimek S, Sommerova P, et al. Porphyromonas gingivalis: major periodontopathic pathogen overview. J Immunol Res. 2014;2014.
Larsen JM. The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017;151(4):363–74.
CAS
PubMed
PubMed Central
Google Scholar
Witte-Händel E, Wolk K, Tsaousi A, et al. The IL-1 pathway is hyperactive in hidradenitis suppurativa and contributes to skin infiltration and destruction. J Investig Dermatol. 2019;139(6):1294–305.
PubMed
Google Scholar
Schlapbach C, Hänni T, Yawalkar N, Hunger RE. Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa. J Am Acad Dermatol. 2011;65(4):790–8.
CAS
PubMed
Google Scholar
Jørgensen AHR, Thomsen SF, Karmisholt KE, Ring HC. Clinical, microbiological, immunological and imaging characteristics of tunnels and fistulas in hidradenitis suppurativa and Crohn’s disease. Exp Dermatol. 2020;29(2):118–23.
PubMed
Google Scholar
Dinh KM, Erikstrup LT, Andersen R, et al. Cross-sectional study identifies lower risk of Staphylococcus aureus nasal colonization in Danish blood donors with hidradenitis suppurativa symptoms. Br J Dermatol. 2020;183(2):387–9.
Katoulis A, Koumaki V, Efthymiou O, et al. Staphylococcus aureus carriage status in patients with hidradenitis suppurativa: an observational cohort study in a tertiary referral hospital in Athens, Greece. Dermatology. 2020;236(1):31–6.
PubMed
Google Scholar
Breuer K, Häussler S, Kapp A, Werfel T. Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis. Br J Dermatol. 2002;147(1):55–61.
CAS
PubMed
Google Scholar
Chehoud C, Rafail S, Tyldsley AS, Seykora JT, Lambris JD, Grice EA. Complement modulates the cutaneous microbiome and inflammatory milieu. Proc Natl Acad Sci. 2013;110(37):15061–6.
CAS
PubMed
Google Scholar
Katz SI, Strober W. The pathogenesis of dermatitis herpetiformis. J Investig Dermatol. 1978;70(2):63–75.
CAS
PubMed
Google Scholar
Maarouf M, Platto JF, Shi VY. The role of nutrition in inflammatory pilosebaceous disorders: implication of the skin-gut axis. Australas J Dermatol. 2019;60(2):e90–8.
PubMed
Google Scholar
Cannistrà C, Finocchi V, Trivisonno A, Tambasco D. New perspectives in the treatment of hidradenitis suppurativa: surgery and brewer’s yeast–exclusion diet. Surgery. 2013;154(5):1126–30.
PubMed
Google Scholar
Aboud C, Zamaria N, Cannistrà C. Treatment of hidradenitis suppurativa: surgery and yeast (Saccharomyces cerevisiae)–exclusion diet. Results after 6 years. Surgery. 2020;167(6):1012–5.
Assan F, Gottlieb J, Tubach F, et al. Anti-Saccharomyces cerevisiae IgG and IgA antibodies are associated with systemic inflammation and advanced disease in hidradenitis suppurativa. J Allergy Clin Immunol. 2020;146(2):452–5.e5.
Quinton J, Sendid B, Reumaux D, et al. Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut. 1998;42(6):788–91.
CAS
PubMed
PubMed Central
Google Scholar
Chen W-T, Chi C-C. Association of hidradenitis suppurativa with inflammatory bowel disease: a systematic review and meta-analysis. JAMA Dermatol. 2019;155(9):1022–7.
PubMed Central
Google Scholar
Frew JW, Hawkes JE, Krueger JG. A systematic review and critical evaluation of inflammatory cytokine associations in hidradenitis suppurativa. F1000Research. 2018;7:1930.
Ring H, Thorsen J, Saunte D, et al. Moderate to severe hidradenitis suppurativa patients do not have an altered bacterial composition in peripheral blood compared to healthy controls. J Eur Acad Dermatol Venereol. 2018;32(1):125–8.
CAS
PubMed
Google Scholar
Frew JW. Hidradenitis suppurativa is an autoinflammatory keratinization disease: a review of the clinical, histologic, and molecular evidence. JAAD Int. 2020;1(1):62–72.
Google Scholar
Perez Perez GI, Gao Z, Jourdain R, et al. Body site is a more determinant factor than human population diversity in the healthy skin microbiome. PLoS One. 2016;11(4):e0151990.
PubMed
PubMed Central
Google Scholar
Gevers D, Knight R, Petrosino JF, et al. The Human Microbiome Project: a community resource for the healthy human microbiome. PLoS Biol. 2012;10(8):e1001377.
CAS
PubMed
PubMed Central
Google Scholar
Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature. 2007;449(7164):804–10.
CAS
PubMed
PubMed Central
Google Scholar
Savin Z, Kivity S, Yonath H, Yehuda S. Smoking and the intestinal microbiome. Arch Microbiol. 2018;200(5):677–84.
CAS
PubMed
Google Scholar
Castaner O, Goday A, Park Y-M, et al. The gut microbiome profile in obesity: a systematic review. Int J Endocrinol. 2018;2018:4095789.
Naik HB, Piguet V. Standardizing hidradenitis suppurativa skin microbiome research: the methods matter. J Investig Dermatol. 2020;140(9):1688–90.
CAS
PubMed
Google Scholar
Prast-Nielsen S, Tobin AM, Adamzik K, et al. Investigation of the skin microbiome: swabs vs. biopsies. Br J Dermatol. 2019;181(3):572–9.
Ardon CB, Prens E, Fuursted K, et al. Biofilm production and antibiotic susceptibility of Staphylococcus epidermidis strains from hidradenitis suppurativa lesions. J Eur Acad Dermatol Venereol. 2019;33(1):170–7.
CAS
PubMed
Google Scholar
Bing M, Forney L, Ravel J. The vaginal microbiome: rethinking health and diseases. Annu Rev Microbiol. 2012;66:371–89.
Google Scholar
Walker AW, Duncan SH, Louis P, Flint HJ. Phylogeny, culturing, and metagenomics of the human gut microbiota. Trends Microbiol. 2014;22(5):267–74.
CAS
PubMed
Google Scholar
Frew JW, Navrazhina K, Byrd A, et al. Defining lesional, perilesional and unaffected skin in hidradenitis suppurativa: proposed recommendations for clinical trials and translational research studies. Br J Dermatol. 2019;181(6):1339–41.
CAS
PubMed
Google Scholar
Jo J-H, Kennedy EA, Kong HH. Research techniques made simple: bacterial 16S ribosomal RNA gene sequencing in cutaneous research. J Investig Dermatol. 2016;136(3):e23–7.
CAS
PubMed
Google Scholar
Kong HH, Andersson B, Clavel T, et al. Performing skin microbiome research: a method to the madness. J Investig Dermatol. 2017;137(3):561–8.
CAS
PubMed
Google Scholar
Kathju S, Lasko L-A, Stoodley P. Considering hidradenitis suppurativa as a bacterial biofilm disease. FEMS Immunol Med Microbiol. 2012;65(2):385–9.
CAS
PubMed
Google Scholar
Ring H, Bay L, Nilsson M, et al. Bacterial biofilm in chronic lesions of hidradenitis suppurativa. Br J Dermatol. 2017;176(4):993–1000.
CAS
PubMed
Google Scholar
Fey PD, Olson ME. Current concepts in biofilm formation of Staphylococcus epidermidis. Future Microbiol. 2010;5(6):917–33.
CAS
PubMed
PubMed Central
Google Scholar
Kimball AB, Kerdel F, Adams D, et al. Adalimumab for the treatment of moderate to severe hidradenitis suppurativa: a parallel randomized trial. Ann Intern Med. 2012;157(12):846–55.
PubMed
Google Scholar
Ribaldone DG, Caviglia GP, Abdulle A, et al. Adalimumab therapy improves intestinal dysbiosis in Crohn’s disease. J Clin Med. 2019;8(10):1646.
CAS
PubMed Central
Google Scholar
Busquets D, Mas-de-Xaxars T, López-Siles M, et al. Anti-tumour necrosis factor treatment with adalimumab induces changes in the microbiota of Crohn’s disease. J Crohns Colitis. 2015;9(10):899–906.
PubMed
Google Scholar
Langan E, Künstner A, Miodovnik M, et al. Combined culture and metagenomic analyses reveal significant shifts in the composition of the cutaneous microbiome in psoriasis. Br J Dermatol. 2019;181(6):1254–64.
CAS
PubMed
Google Scholar
Slocum C, Kramer C, Genco C. Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis. J Intern Med. 2016;280(1):114–28.
CAS
PubMed
Google Scholar
Ahn J, Chen CY, Hayes RB. Oral microbiome and oral and gastrointestinal cancer risk. Cancer Causes Control. 2012;23(3):399–404.
PubMed
PubMed Central
Google Scholar
Machado MO, Stergiopoulos V, Maes M, et al. Depression and anxiety in adults with hidradenitis suppurativa: a systematic review and meta-analysis. JAMA Dermatol. 2019;155(8):939–45.
PubMed Central
Google Scholar