Skip to main content
SpringerLink
Log in

La présepsine (sCD14-ST), nouveau biomarqueur de la réponse anti-infectieuse

Presepsin (sCD14-ST), an emergent and promising biomarker of infection

  • Mise au Point / Update
  • Published:
Annales françaises de médecine d'urgence

Résumé

La réponse immunitaire innée, première barrière de l’organisme contre l’infection, repose sur la reconnaissance des antigènes microbiens par des récepteurs spécifiques associés au corécepteur membranaire CD14. Après reconnaissance du pathogène et activation des voies de signalisation intracellulaire des mécanismes de défense, le CD14 est libéré dans la circulation sous la forme d’un produit de clivage stable (sous-type du CD14 soluble ou sCD14-ST) qui peut être détecté par des méthodes biochimiques automatisées. Les caractéristiques de cette protéine appelée présepsine en font un marqueur émergent de l’infection, pour lequel des données apparaissent dans la littérature scientifique. L’objet de cet article est de décrypter le rationnel d’utilisation de la présepsine et de décrire les éléments scientifiques supportant son actuel développement.

Abstract

Innate immunity is the first barrier to fight off bacteria. It partly relies on engagement of the membrane coreceptor CD14. A product of cleavage of CD14, named soluble subtype of CD14 (sCD14-ST) or presepsin, is released in the circulation after activation of defense mechanisms. Presepsin can be detected by biochemical methods and therefore appears as an emergent biomarker of infection. An increasing number of studies are currently published that helps understanding the strength and weakness of this biomarker in the field of emergency medicine and sepsis. Reports evaluate the characteristics of presepsin in evaluation of diagnosis and, in a lesser extent, in prognosis of patients with suspected infection. Here we present the rational for presepsin development and recent data supporting its utility at bedside.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Références

  1. Medzhitov R, Janeway C (2000) Innate immunity. N Engl J Med 343:338–344

    Article  PubMed  CAS  Google Scholar 

  2. Hancock R (2001) Cationic peptides: effector ininnate immunity and novel antimicrobials. Lancet 1:156–164

    CAS  Google Scholar 

  3. Modlin R, Brightbill H, Godowski P (1999) The toll of innate immunity on microbial pathogens. N Engl J Med 340:1834–1835

    Article  PubMed  CAS  Google Scholar 

  4. Poussin C, Foti M, Carpentier JL, et al (1998) CD14 dependent endotoxin internalization via a macropinocytic pathway. J Biol Chem 273:20285–20291

    Article  PubMed  CAS  Google Scholar 

  5. Berner R, Fürll B, Stelter F, et al (2002) Elevated levels of lipopolysaccharide-binding protein and soluble CD14 in plasma in neonatal early-onset sepsis. Clin Diagn Lab Immunol 9:440–445

    PubMed  CAS  Google Scholar 

  6. Landmann R, Reber AM, Sansano S, et al (1996) Function of soluble CD14 in serum from patients with septic shock. J Infect Dis 173:661–668

    Article  PubMed  CAS  Google Scholar 

  7. Pavcnik-Arnol M, Hojker S, Derganc M (2007) Lipopolysaccharide-binding protein, lipopolysaccharide, and soluble CD14 in sepsis of critically ill neonates and children. Intensive Care Med 33:1025–1032

    Article  PubMed  CAS  Google Scholar 

  8. Landmann R, Zimmerli W, Sansano S, et al (1995) Increased circulating soluble CD14 is associated with high mortality in gramnegative septic shock. J Infect Dis 171:639–644

    Article  PubMed  CAS  Google Scholar 

  9. Shozushima T, Takahashi G, Matsumoto N, et al (2011) Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J Infect Chemother 17:764–769

    Article  PubMed  CAS  Google Scholar 

  10. Yaegashi Y, Shirakawa K, Sato N, et al (2005) Evaluation of a newly identified soluble CD14 subtype as a marker for sepsis. J Infect Chemother 11:234–238

    Article  PubMed  CAS  Google Scholar 

  11. Okamura Y, Yokoi H (2011) Development of a point-of-care assay system for measurement of presepsin (sCD14-ST). Clin Chim Acta 412:2157–2161

    Article  PubMed  CAS  Google Scholar 

  12. Endo S, Suzuki Y, Takahashi G, et al (2012) Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study. J Infect Chemother 18:891–897

    Article  PubMed  CAS  Google Scholar 

  13. Riquelme R, Torres A, el-Ebiary M, et al (1997) Communityacquired pneumonia in the elderly. Clinical and nutritional aspects. Am J Resp Crit Care Med 156:1908–1914

    Article  PubMed  CAS  Google Scholar 

  14. Urbonas V, Eidukaite A, Tamuliene I (2013) The predictive value of soluble markers (CD14 subtype, interleukin-2 receptor, human leucocyte-antigen) and procalcitonin in the detection of bacteraemia and sepsis in pediatric oncology patients with chemotherapyinduced febrile neutropenia. Cytokine 62:34–37

    Article  PubMed  CAS  Google Scholar 

  15. Palmiere C, Mussap M, Bardy D, et al (2013) Diagnostic value of soluble CD14 subtype (sCD14-ST) presepsin for the post-mortem diagnosis of sepsis-related fatalities. Int J Legal Med (in press)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Département de médicine d’urgence, centre hospitalier Princesse-Grace, 1, avenue Pasteur, BP489 MC-98012, Principauté de Monaco, France

    T. Mallet-Coste, X. Magdelein, F. Brod & Y. -E. Claessens

  2. Service de biochimie, hôpital Cochin-Hôtel-Dieu, AP-HP, 27, rue du Faubourg-Saint-Jacques, F-75679, Paris cedex 14, France

    C. Chenevier-Gobeaux

  3. Département de biologie, centre hospitalier Princesse-Grace, 1, avenue Pasteur, BP489 MC-98012, Principauté de Monaco, France

    C. Fissore-Magdelein

Authors
  1. T. Mallet-Coste
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Chenevier-Gobeaux
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Fissore-Magdelein
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. X. Magdelein
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Brod
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Y. -E. Claessens
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Y. -E. Claessens.

About this article

Cite this article

Mallet-Coste, T., Chenevier-Gobeaux, C., Fissore-Magdelein, C. et al. La présepsine (sCD14-ST), nouveau biomarqueur de la réponse anti-infectieuse. Ann. Fr. Med. Urgence 3, 305–309 (2013). https://doi.org/10.1007/s13341-013-0347-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13341-013-0347-5

Mots clés

Keywords

Search

Navigation