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Periodontal diseases assessed by average bone resorption are associated with microvascular complications in patients with type 2 diabetes

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Abstract

Periodontal disease often develops in patients with diabetes, and further exacerbated with diabetic complications. It would be clinically important to clarify the relationship between diabetic microvascular diseases and periodontal disease. This study aimed to evaluate the association between periodontal disease and diabetic complications in patients with type 2 diabetes with poor glycemic control. A total of 447 patients with type 2 diabetes hospitalized at Rakuwakai Otowa Hospital, Japan, were initially recruited in this study. After excluding 134 patients who lacked clinical data or were edentulous, 312 were included in our study. The severity of periodontal disease was evaluated based on the average bone resorption rate. Patients with diabetic nephropathy developed severe periodontal disease (multivariate-adjusted odds ratio, 3.00 [95% CI 1.41–5.19]). Diabetic neuropathy was positively associated with the severity of periodontal disease; the multivariate-adjusted odds ratio (95% CI) was 1.62 (0.87‒2.99) for moderate and 4.26 (2.21‒8.20) for severe periodontal disease. In contrast, diabetic retinopathy was linked with moderate periodontal disease (multivariate-adjusted odds ratio 2.23 [95% CI 1.10–4.10]), but not with severe conditions (multivariate-adjusted odds ratio 0.92 [95% CI 0.67–3.07]). In conclusion, periodontal disease, evaluated by average bone resorption rate, was associated with diabetic nephropathy and neuropathy.

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Acknowledgements

We would like to thank Editage (http://www.editage.com) for English language editing.

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Authors and Affiliations

  1. Kyoto Oral Health Center, Rakuwakai Otowa Hospital, 2 Otowachinjicho, Yamashina-ku, Kyoto, Japan

    Noriko Sugi

  2. Department of Public Health, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Okayama, Japan

    Eri Eguchi

  3. Department of Pathophysiology-Periodontal Science, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Okayama, Japan

    Ayaka Tsuboi, Kazu Hatanaka & Shogo Takashiba

  4. Diabetes and Endocrinology Lifestyle-Related Disease Center, Rakuwakai Otowa Hospital, Kyoto, Japan

    Yuri Kira, Masako Miura & Kentaro Doi

  5. Department of Environmental Medicine, Faculty of Medicine, Kochi University, Kochi, Japan

    Keiki Ogino

  6. Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Keita Hirano

  7. Department of Nephrology, Rakuwakai Otowa Hospital, Kyoto, Japan

    Takahiko Nakagawa

  8. Takashima Municipal Hospital, Shiga, Japan

    Kentaro Doi

Authors
  1. Noriko Sugi
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  2. Eri Eguchi
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Corresponding author

Correspondence to Noriko Sugi.

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All authors declare no conflict interest associated with this manuscript.

Human rights statement and informed consent

This study was conducted with the Ethics Review Committee of Rakuwakai Otowa Hospital (The approval number 17-014), which was approved on Apr. 27. 2017, and the Ethics Committee of Okayama University (The approval number 1706-041), which was approved on June.16, 2017. Written informed consent was waived due to its retrospective nature. An opt-out procedure was conducted to allow patients to withdraw from the study by informing them of the study protocol on the hospital homepage website, as advised by the committee.

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Sugi, N., Eguchi, E., Tsuboi, A. et al. Periodontal diseases assessed by average bone resorption are associated with microvascular complications in patients with type 2 diabetes. Diabetol Int 14, 32–39 (2023). https://doi.org/10.1007/s13340-022-00591-0

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  • DOI: https://doi.org/10.1007/s13340-022-00591-0

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