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Serum Magnesium Levels in Children With and Without Migraine: A Cross-Sectional Study

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Abstract

Objective

To study the association between serum magnesium level and migraine in children.

Methods

This cross-sectional study enrolled children aged 5–18 years diagnosed with migraine, and age- and sex-matched controls without a headache disorder. International Classification of Headache Disorders 3 (ICHD-3) was used for the diagnosis of migraine. The association between serum magnesium level and migraine headache was analyzed.

Results

A total of 35 children with migraine were enrolled with 35 control subjects. The median (IQR) serum magnesium levels were comparable among children with migraine and controls [2.0 (2.0,2.1) vs 2.2 (1.9, 2.2) mg/dL; P=0.23], respectively. In adolescent subgroup, median (IQR) serum magnesium levels were significantly low among the children with migraine as compared to those without migraine [2.0 (1.9, 2.1) vs 2.2 (2.0, 2.2 mg/dL); P<0.045].

Conclusion

We found a statistically significant association between low serum magnesium levels and the occurrence of migraine in adolescents, which may have treatment implications.

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Funding

Funding: None; Competing interest: None stated.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India

    Rishab Bhurat &  Sarala Premkumar

  2. Department of Pediatric Neurology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India

    Ranjith Kumar Manokaran

Authors
  1. Rishab Bhurat
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  2. Sarala Premkumar
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  3. Ranjith Kumar Manokaran
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Contributions

Contributors: RB: study design, acquisition, analysis, drafting; SP: study design, analysis, interpretation and drafting; RKM: study design, interpretation, revising it critically. Final approval of the version and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved by all the contributing authors.

Corresponding author

Correspondence to Sarala Premkumar.

Ethics declarations

Ethics clearance: IEC Sri Ramachandra Institute of Higher Education and Research; No. CSP-MED/18 JUN/44/104 dated June 23, 2018.

Additional information

Note: Additional material related to this study is available with the online version at https://www.indianpediatrics.net.

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Bhurat, R., Premkumar, S. & Manokaran, R.K. Serum Magnesium Levels in Children With and Without Migraine: A Cross-Sectional Study. Indian Pediatr 59, 623–625 (2022). https://doi.org/10.1007/s13312-022-2576-4

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  • DOI: https://doi.org/10.1007/s13312-022-2576-4

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