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Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children With Cerebral Palsy

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Abstract

Objective

To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin-like growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age- and gender-matched controls.

Methods

A cross-sectional study enrolled 30 children in each group: CP with epilepsy, CP without epilepsy, and healthy controls. Bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.

Results

z-scores of BMD [−1.80 (1.03), −2.12 (0.85) vs −1.40 (0.90); P<0.01], 25-OHD levels [19.26 (8.28), 20.59 (8.92) Vs 26.79 (12.76) ng/mL; P<0.01] and IGF-1 levels [20.90 (6.42), 23.37 (8.11) vs 31.77 (11.21) ng/mL; P<0.01] were significantly low among children with CP with epilepsy, CP without epilepsy when compared to controls.

Conclusion

Children with CP with or without comorbid epilepsy were prone to vitamin D deficiency, low bone mineral density and growth hormone axis suppression with low IGF-1 levels.

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References

  1. Colver A, Fairhurst C, Pharoah PO. Cerebral palsy. Lancet Lond Engl. 2014;383:1240–9.

    Article  Google Scholar 

  2. Gulati S, Sondhi V. Cerebral palsy: An overview. Indian J Pediatr. 2018;85:1006–16.

    Article  Google Scholar 

  3. Seth A, Aneja S, Singh R, et al. Effect of impaired ambulation and anti-epileptic drug intake on vitamin D status of children with cerebral palsy. Paediatr Int Child Health. 2017;37:193–8.

    Article  Google Scholar 

  4. Ali O, Shim M, Fowler E, et al. Spinal bone mineral density, IGF-1 and IGFBP-3 in children with cerebral palsy. Horm Res. 2007;68:316–20.

    CAS  PubMed  Google Scholar 

  5. Houlihan CM, Stevenson RD. Bone density in cerebral palsy. Phys Med Rehabil Clin N Am. 2009;20:493–508.

    Article  Google Scholar 

  6. Leonard M, Dain E, Pelc K, et al. Nutritional status of neurologically impaired children: Impact on comorbidity. Arch Pediatr. 2020;27:95–103.

    Article  CAS  Google Scholar 

  7. Grether JK, Cummins SK, Nelson KB. The California Cerebral Palsy Project. Paediatr Perinat Epidemiol. 1992;6:339–51.

    Article  CAS  Google Scholar 

  8. Akpinar P. Vitamin D status of children with cerebral palsy: Should vitamin D levels be checked in children with cerebral palsy? North Clin Istanb. 2018;5:341–7.

    PubMed  PubMed Central  Google Scholar 

  9. Niu T, Rosen CJ. The insulin-like growth factor-I gene and osteoporosis: A critical appraisal. Gene. 2005;361:38–56.

    Article  CAS  Google Scholar 

  10. Rosen CJ, Ackert-Bicknell CL, Adamo ML, et al. Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. Bone. 2004;35:1046–58.

    Article  CAS  Google Scholar 

  11. Nazif H, Shatla R, Elsayed R, et al. Bone mineral density and insulin-like growth factor-1 in children with spastic cerebral palsy. Childs Nerv Syst. 2017;33:625–30.

    Article  CAS  Google Scholar 

  12. Ala-Houhala M, Korpela R, Koivikko M, et al. Long-term anticonvulsant therapy and vitamin D metabolism in ambulatory pubertal children. Neuropediatrics. 1986;17: 212–6.

    Article  CAS  Google Scholar 

  13. Singhi P, Saini AS. Changes in the clinical spectrum of cerebral palsy over two decades in north India- an analysis of 1212 cases. J Trop Pediatr. 2013;59:434–40.

    Article  Google Scholar 

  14. Goyal R, Rana R, Bhatia H, et al. Nutritional status of Indian children with cerebral palsy: A cross-sectional study. Indian J Pediatr. 2020;87:225.

    Article  Google Scholar 

  15. Tosun A, Erisen Karaca S, Unuvar T, et al. Bone mineral density and vitamin D status in children with epilepsy, cerebral palsy, and cerebral palsy with epilepsy. Childs Nerv Syst. 2017;33:153–8.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, 124 001, India

    Namita Gwasikoti, Kapil Bhalla & Jaya Shankar Kaushik

  2. Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana, India

    Veena Singh Ghalaut

  3. Department of Orthopedics, Pt. BD Sharma PGIMS, Rohtak, Haryana, India

    Zile Singh Kundu

Authors
  1. Namita Gwasikoti
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  2. Kapil Bhalla
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  3. Jaya Shankar Kaushik
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  4. Veena Singh Ghalaut
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  5. Zile Singh Kundu
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Corresponding author

Correspondence to Kapil Bhalla.

Additional information

Ethics clearance

Institutional ethics committee, PLBD Sharma, PGIMS; No. BREC/Th/19/Ped 15; dated March 06, 2020.

Note

Presented in 19th Annual Conference of Neurology Chapter of Indian Academy of Pediatrics, 26–28 July, 2019, Hyderabad, Telengana.

Contributors

KB, JSK: conceptualized the idea; NG, KB, JSK, VSG, ZSK: involved in data collection and patient management; NG, KB, JSK: drafted the manuscript; VSG, ZSK: provided intellectual inputs; all the authors the final version of the manuscript.

Funding

None

Competing interests

None stated.

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Cite this article

Gwasikoti, N., Bhalla, K., Kaushik, J.S. et al. Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children With Cerebral Palsy. Indian Pediatr 58, 836–838 (2021). https://doi.org/10.1007/s13312-021-2303-6

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  • DOI: https://doi.org/10.1007/s13312-021-2303-6

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