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Bone mineral density and insulin-like growth factor-1 in children with spastic cerebral palsy

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Abstract

Background

Children with cerebral palsy (CP) have significant decrease linear growth rate and low bone mineral density (BMD).

Aims

This study is to evaluate BMD in children with CP and its relation to the levels of insulin-like growth factor-1 (IGF-1).

Subjects and methods

This cross-sectional study was carried out on 58 children suffering from spastic CP with the age range 4–12 years compared to 19 controls. All assessed by dual energy x-ray absorptiometry (DXA) to measure BMD, serum level of IGF-1, and serum vitamin D. The patients were classified according to their GMFCS.

Results

Fractures were reported in seven (12.1%) of cases. Our study demonstrated that, IGF-1 level and BMD decrease in correlation with the severity of CP. IGF-1correlates positively with serum vitamin D, BMI, and BMD. CP children with severe GMFCS level or who use anticonvulsive drugs are at a high risk for low BMD and low levels of IGF-1.

Conclusion

Both BMD and IGF-1 were significantly in low children with spastic CP; IGF-1 negatively correlates with the severity of osteopenia in children with spastic. Children with CP who are not independently ambulant or with severe GMFCS level or who use anticonvulsive drugs are at a high risk for developing low BMD.

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Author information

Authors and Affiliations

  1. Department of Childhood Medical Studies, Institute of Postgraduate Childhood Studies, Ain Shams University, Cairo, Egypt

    H Nazif & A Ibrahim

  2. Department of Pediatrics, Pediatric Neurology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    R Shatla

  3. Deparment of Pediatrics, Pediatric Neurology Unit, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt

    R Elsayed

  4. Department of Physical Medicine, Rheumatology and Rehabilitation Faculty of Medicine, Ain Shams University, Cairo, Egypt

    E Tawfik

  5. Department of Radio Diagnoses, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    N Osman

  6. Department of Molecular Biology, National Center for Radiation Research and Technology, Cairo, Egypt

    S Korra

Authors
  1. H Nazif
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  2. R Shatla
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  3. R Elsayed
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  4. E Tawfik
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  5. N Osman
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  6. S Korra
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  7. A Ibrahim
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Corresponding author

Correspondence to R Elsayed.

Ethics declarations

Parents were informed about the aims and the procedures of the study. A written informed consent was signed from parents to enroll their children in the study as well as an ascent from the patient. The study was approved by the local ethical committee of our hospital.

Conflict of interest

All authors stated that no conflict of interest related to this article.

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Nazif, H., Shatla, R., Elsayed, R. et al. Bone mineral density and insulin-like growth factor-1 in children with spastic cerebral palsy. Childs Nerv Syst 33, 625–630 (2017). https://doi.org/10.1007/s00381-017-3346-9

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  • DOI: https://doi.org/10.1007/s00381-017-3346-9

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