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Question about Liu Y et al. entitled “Effect of c-erbB2 overexpression on prognosis in osteosarcoma: evidence from eight studies”

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Tumor Biology

Abstract

We read with great interest on the recent paper by Liu Y et al. “Effect of c-erbB2 overexpression on prognosis in osteosarcoma: evidence from eight studies” published online in Tumor Biology (Tumor Biol 5(9):8939-43, 2014). The investigators (Liu Y et al.) performed a meta-analysis to study the relationship between c-erbB2 expression and prognostic impact in patients with osteosarcoma. They conducted a comprehensive and detailed meta-analysis to reveal the prognostic role of c-erbB2 for osteosarcoma. As a result, eight studies with 411 osteosarcoma patients were involved to estimate the relationship. Positive expressions of c-erbB2 predicted poorer survival in osteosarcoma patients with the pooled RR of 1.53 (95 % CI 1.20–1.94, P = 0.0006). Finally, they concluded that c-erbB2 overexpression is related to poor prognostic of osteosarcoma and can be a useful clinical prognostic factor for those patients. Nevertheless, we have several queries which we would like to communicate with them.

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Authors and Affiliations

  1. Changning Hospital Of Traditional Chinese Medicine, Changning, 421500, Hunan, China

    Xinsheng Yin, Fangwen Deng & Guoping Liao

  2. Department of Pharmacy, Zhujiang Hospital of Southern Medical University, Guangzhou, 510282, Guangdong, China

    Guoping Liao

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  1. Xinsheng Yin
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  2. Fangwen Deng
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  3. Guoping Liao
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Correspondence to Guoping Liao.

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Yin, X., Deng, F. & Liao, G. Question about Liu Y et al. entitled “Effect of c-erbB2 overexpression on prognosis in osteosarcoma: evidence from eight studies”. Tumor Biol. 36, 6667–6668 (2015). https://doi.org/10.1007/s13277-015-3856-6

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  • DOI: https://doi.org/10.1007/s13277-015-3856-6

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