Immunohistochemical study of p53, VEGF, Flt-1/VEGFR1 Ab-1, EGFR, HER-2/neu, Bax, and Cox-2 expression in osteosarcomas was carried out in 40 patients aged 16-70 years. Expression of p53 was detected in 27.5% tumors, VEGF in 15%, Flt-1/VEGFR1 Ab-1 in 97.5%, EGFR in 52.5%, HER-2/neu in 32.5%, Bax in 77.8%, and Cox-2 in 32.3% tumors. Multifactorial analysis showed that the expression of HER-2/neu (p=0.004), p53 (p=0.01), and Cox-2 (p=0.04) in osteosarcomas significantly correlated with unfavorable prognosis for overall survival, while HER-2/neu (p=0.02) and Cox-2 (p=0.003) with relapse-free survival. Analysis of HER-2/neu, p53, and Cox-2 expression in the primary tumor should be taken into consideration in the treatment of patients with osteosarcoma.
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References
G. I. Abelev and T. L. Eraizer, Biokhimiya, 73, No. 5, 605-618 (2008).
N. V. Zhukov and S. A. Tyulyandin, Ibid., 751-768 (2008).
E. N. Imyanitov and K. P. Khanson, Molecular Oncology: Clinical Aspects [in Russian], St. Petersburg (2007).
Manual of Immunohistochemical Diagnosis of Human Tumors, Eds. S. V. Petrov and N. T. Raikhlin [in Russian], 3rd ed., Kazan (2004).
G. A. Frank, L. E. Zavalishina, and Yu. Yu. Andreeva, Precise Diagnosis of Cancer by Immunohistochemical Evaluation of Markers [in Russian], Moscow (2009).
J. Bajpai, M. Sharma, V. Sreenivas, et al., Pediatr. Blood Cancer, 53, No. 6, 1035-1039 (2009).
S. Bakhshi, A. Gupta, M. C. Sharma, et al., Pediatr. Hematol. Oncol., 31, No. 4, 245-251 (2009).
M. K. Kaseta, L. Khaldi, I. P. Gomatos, et al., J. Surg. Oncol., 97, No. 3, 259-266 (2008).
M. Kaya, T. Wada, S. Nagoya, et al., J. Bone Joint Surg. Br., 91, No. 6, 784-788 (2009).
L. Masi, R. Recenti, S. Silvestri, et al., Appl. Immunohistochem. Mol. Morphol., 15, No. 1, 70-76 (2007).
T. Nedelcu, B. Kubista, A. Koller, et al., J. Cancer Res. Clin. Oncol., 134, No. 2, 237-244 (2008).
M. Onda, S. Matsuda, S. Higaki, et al., Cancer, 77, No. 1, 71-78 (1996).
H. R. Park, K. Min, H. S. Kim, et al., Pathol. Res. Pract., 204, No. 8, 575-582 (2008).
J. Y. Tsai, H. Aviv, J. Benevenia, et al., Cancer Invest., 22, No. 1, 16-24 (2004).
H. Urakawa, Y. Nishida, T. Naruse, et al., Clin. Orthop. Relat. Res., 467, No. 11, 2932-2938 (2009).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 8, pp. 202-207, August, 2010
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Boulytcheva, I.V., Soloviev, Y.N., Kushlinskii, N.E. et al. Expression of Molecular Markers in the Tumor and Survival Prognosis in Osteosarcoma. Bull Exp Biol Med 150, 237–242 (2010). https://doi.org/10.1007/s10517-010-1114-x
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DOI: https://doi.org/10.1007/s10517-010-1114-x