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Brain identification of IBS patients based on GBDT and multiple imaging techniques

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Abstract

The brain biomarker of irritable bowel syndrome (IBS) patients is still lacking. The study aims to explore a new technology studying the brain alterations of IBS patients based on multi-source brain data. In the study, a decision-level fusion method based on gradient boosting decision tree (GBDT) was proposed. Next, 100 healthy subjects were used to validate the effectiveness of the method. Finally, the identification of brain alterations and the pain evaluation in IBS patients were carried out by the fusion method based on the resting-state fMRI and DWI for 46 patients and 46 controls selected randomly from 100 healthy subjects. The results showed that the method can achieve good classification between IBS patients and controls (accuracy = 95%) and pain evaluation of IBS patients (mean absolute error = 0.1977). Moreover, both the gain-based and the permutation-based evaluation instead of statistical analysis showed that left cingulum bundle contributed most significantly to the classification, and right precuneus contributed most significantly to the evaluation of abdominal pain intensity in the IBS patients. The differences seem to suggest a probable but unexplored separation about the central regions between the identification and progression of IBS. This finding may provide one new thought and technology for brain alteration related to IBS.

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Data availability

The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This work was supported by the Young Teacher Foundation of Henan Province [No. 2021GGJS093 and 2020GGJS123], the Project for the Science and Technology Planning Program of Henan Province [No. 232102211003, 22A520046, and 232102210062] and Henan Key Laboratory of Food Safety Data Intelligence.

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Authors and Affiliations

  1. School of Computer and Communication Engineering, Zhengzhou University of Light Industry, 136 Science Avenue, Zhengzhou, 450000, Henan, China

    Li Han, Qian Xu, Panting Meng, Ruyun Xu & Jiaofen Nan

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  1. Li Han
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  2. Qian Xu
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  3. Panting Meng
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Contributions

LH and JN: conceptualization and investigation. LH, QX, PM and JN: methodology, writing—original draft preparation and editing. JN, PM and LH: resources, software, and validation. LH and RX: writing—review and supervision. All authors contributed to the article and approved the submitted version.

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Correspondence to Jiaofen Nan.

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The authors declare that they have no conflict of interest.

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The study was approved by the Institutional Review Board of the First Affiliated Hospital of the Medical College in Xi’an Jiaotong University (2013KL011). Prior to the study, all participants provided written informed consent.

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Han, L., Xu, Q., Meng, P. et al. Brain identification of IBS patients based on GBDT and multiple imaging techniques. Phys Eng Sci Med (2024). https://doi.org/10.1007/s13246-024-01394-0

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