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Phenomenological characterization of blood’s intermediate shear rate: a new concept for hemorheology

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Abstract

The phenomena of aggregation, breakdown, and disaggregation of the rouleaux of red blood cells (RBCs) in addition to deformability affect the human blood viscosity at different shear rates. In this study, the intermediate shear rate is introduced and defined when the effect of aggregation on the change of blood viscosity is diminished; and afterwards, the alteration in the blood viscosity is dominantly affected by the deformation of RBCs. With this respect, modeling the effective parameters on the blood shear-thinning behavior including hematocrit and plasma viscosity was performed for the two different shear regions discriminated by the proposed intermediate shear rates. The presented rheological model reflects a phenomenological approach to assess the human blood viscosity with an average error of ± 5% compared to experimental data for hematocrits between 0.299 and 0.702, subjected to various shear rates from 0.2 to 680 1/s. The temperature changes as well as biochemical effects on whole blood viscosity are characterized by the introduced plasma viscosity-dependent model. The presented comprehensive model could be used for better understanding of blood flow hemodynamics and analyzing the shear dependence of aggregation and deformability behaviors of RBCs.

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Authors and Affiliations

  1. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, North Kargar Street, 14399, Tehran, Iran

    Hadi Tabesh, Ali Poorkhalil, Homa Akbari & Fojan Rafiei

  2. Institute of Physiology, Aachen University Hospital, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany

    Khosrow Mottaghy

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  1. Hadi Tabesh
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  2. Ali Poorkhalil
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  3. Homa Akbari
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Correspondence to Hadi Tabesh.

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Hadi Tabesh, Ali Poorkhalil, Homa Akbari, Fojan Rafiei and Khosrow Mottaghy declares that they have no conflict of interest.

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Tabesh, H., Poorkhalil, A., Akbari, H. et al. Phenomenological characterization of blood’s intermediate shear rate: a new concept for hemorheology. Phys Eng Sci Med 45, 1205–1217 (2022). https://doi.org/10.1007/s13246-022-01188-2

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  • DOI: https://doi.org/10.1007/s13246-022-01188-2

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