Cardiovascular Engineering and Technology

, Volume 5, Issue 4, pp 317–333 | Cite as

A Stent with Customizable Length for Treatment of Critical Limb Ischemia: Clinical Need, Device Development and Pre-clinical Testing

  • Barry O’Brien
  • Eoin O’Cearbhaill
  • Mark Bruzzi
Article

Abstract

Critical limb ischemia (CLI) is typically associated with a poor prognosis in the absence of a revascularization treatment. While surgical revascularization can be successful, there is an increasing desire for minimally invasive therapies, particularly in the more distal, infrapopliteal arteries. These small vessels contribute significantly to CLI, especially in diabetic CLI patients. This study describes a unique multi-segmented self-expanding stent developed specifically for use in infrapopliteal revascularization procedures. The number of segments deployed can be selected to optimize the stented length and location. The device may provide an adjunctive treatment in instances of sub-optimal balloon angioplasty when treating CLI. The clinical opportunity for the device is presented, followed by a description of the design and the design process. The results from a range of bench testing are presented as well as the findings of porcine studies to assess in vivo behaviour. In summary, while further development is needed, this study has demonstrated the feasibility of this novel device.

Keywords

Self-expanding Infrapopliteal Angioplasty Multi-segmented Radial force Oversizing 

Supplementary material

Supplementary material 1 (WMV 20778 kb)

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Copyright information

© Biomedical Engineering Society 2014

Authors and Affiliations

  • Barry O’Brien
    • 1
  • Eoin O’Cearbhaill
    • 1
    • 2
  • Mark Bruzzi
    • 1
  1. 1.Biomedical Engineering, College of Engineering and InformaticsNational University of Ireland GalwayGalwayIreland
  2. 2.School of Mechanical & Materials EngineeringUniversity College DublinDublinIreland

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