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Bioactive Natural and Synthetic Polymers for Wound Repair

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Abstract

Wound healing is a dynamic and complicated process that needs a favorable environment to facilitate healing. Although gauze, lint, plasters, bandages (natural or synthetic), and cotton wool used as primary or secondary dressings to protect the wound from contamination, they have several deficiencies. Thus, modern wound dressings have been designed by the use of natural and synthetic polymers that contribute to wound healing rather than merely covering it. These dressings such as hydrogels, films, and foams are designed to prevent dehydration, control infection and inflammation, and enhance wound healing. In this review article, different natural and synthetic polymers for the preparation of these wound dressings, including hydrogel, film, foam, and smart ones have been discussed. Moreover, the use of natural compounds such as honey and oleoresin for wound healing has been investigated. Hopefully, this review will provide a helpful perspective for future research.

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References

  1. J. Grip, R. E. Engstad, I. Skjæveland, N. Škalko-Basnet, and A. M. Holsæter, Eur. J. Pharm. Sci., 107, 24 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. G. Han and R. Ceilley, Adv. Ther., 34, 599 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  3. S. Saghazadeh, C. Rinoldi, M. Schot, S. S. Kashaf, F. Sharifi, E. Jalilian, K. Nuutila, G. Giatsidis, P. Mostafalu, H. Derakhshandeh, K. Yue, W. Swieszkowski, A. Memic, A. Tamayol, and A. Khademhosseini, Adv. Drug Deliv. Rev., 127, 138 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. J. S. Boateng, K. H. Matthews, H. N. Stevens, and G. M. Eccleston, J. Pharm. Sci., 97, 2892 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. A. Sood, M. S. Granick, and N. L. Tomaselli, Adv. Wound Care (New Rochelle), 3, 511 (2014).

    Article  Google Scholar 

  6. E. R. Ghomi, S. Khalili, S. N. Khorasani, R. E. Neisiany, and S. Ramakrishna, J. Appl. Polym. Sci., 136, 47738 (2019).

    Article  CAS  Google Scholar 

  7. J. Dissemond, Hautarzt, 57, 881 (2006).

    Article  CAS  PubMed  Google Scholar 

  8. S. Dhivya, V. V. Padma, and E. Santhini, BioMedicine, 5, 22 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  9. N. J. Percival, Surgery (Oxford), 20, 114 (2002).

    Article  Google Scholar 

  10. M. E. Okur, I. D. Karantas, Z. Şenyiğit, N. Ü. Okur, and P. I. Siafaka, Asian J. Pharm. Sci., 15, 661 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  11. G. C. Gurtner, S. Werner, Y. Barrandon, and M. T. Longaker, Nature, 453, 314 (2008).

    Article  CAS  PubMed  Google Scholar 

  12. X. Zhang, W. Shu, Q. Yu, W. Qu, Y. Wang, and R. Li, Front. Bioeng. Biotechnol., 8, 516 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  13. B. A. Nicks, E. A. Ayello, K. Woo, D. Nitzki-George, and R. G. Sibbald, Int. J. Emerg. Med., 3, 399 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  14. S. Thomas, P. Loveless, and N. Hay, Pharm. J., 240, 785 (1988).

    CAS  Google Scholar 

  15. K. K. Hoffmann, D. J. Weber, G. P. Samsa, and W. A. Rutala, JAMA, 267, 2072 (1992).

    Article  CAS  PubMed  Google Scholar 

  16. S. Seaman, J. Am. Podiatr. Med. Assoc., 92, 24 (2002).

    Article  PubMed  Google Scholar 

  17. X. Liu, Y. Niu, K. C. Chen, and S. Chen, Mater. Sci. Eng. C Mater. Biol. Appl., 71, 289 (2017).

    Article  CAS  PubMed  Google Scholar 

  18. I. Negut, V. Grumezescu, and A. M. Grumezescu, Molecules, 23, 2392 (2018).

    Article  PubMed Central  CAS  Google Scholar 

  19. S. Enoch and D. J. Leaper, Surgery (Oxford), 26, 31 (2008).

    Article  Google Scholar 

  20. B. Larson, A. Nauta, K. Kawai, M. T. Longaker, and H. P. Lorenz, in Advanced Wound Repair Therapies, Woodhead Publishing Limited, Cambridge, 2011, pp 77–111.

    Book  Google Scholar 

  21. T. J. Koh and L. A. DiPietro, Expert. Rev. Mol. Med., 13, e23 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  22. N. X. Landén, D. Li, and M. Ståhle, Cell. Mol. Life Sci., 73, 3861 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  23. P. H. Wang, B. S. Huang, H. C. Horng, C. C. Yeh, and Y. J. Chen, J. Chin. Med. Assoc., 2, 94 (2018).

    Article  Google Scholar 

  24. X. Yang, J. Wang, S. L. Guo, K. J. Fan, J. Li, Y. L. Wang, Y. Teng, and X. Yang, Int. J. Biol. Sci., 7, 685 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. L. E. Tracy, R. A. Minasian, and E. J. Caterson, Adv. Wound Care (New Rochelle), 5, 119 (2016).

    Article  Google Scholar 

  26. A. C. Gonzalez, T. F. Costa, Z. A. Andrade, and A. R. Medrado, An. Bras. Dermatol., 91, 614 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  27. R. J. Hinchliffe, G. D. Valk, J. Apelqvist, D. G. Armstrong, K. Bakker, F. L. Game, A. Hartemann-Heurtier, M. Löndahl, P. E. Price, W. H. van Houtum, and W. J. Jeffcoate, Diabetes Metab. Res. Rev., 24, S119 (2008).

    Article  PubMed  Google Scholar 

  28. N. Greer, N. A. Foman, R. MacDonald, J. Dorrian, P. Fitzgerald, I. Rutks, and T. J. Wilt, Ann. Intern. Med., 159, 532 (2013).

    Article  PubMed  Google Scholar 

  29. R. J. White, K. Cutting, and A. Kingsley, Ostomy Wound Manage, 52, 26 (2006).

    PubMed  Google Scholar 

  30. M. Abbasipour, M. Mirjalili, R. Khajavi, and M. M. Majidi, J. Eng. Fiber Fabr., 9, 124 (2014).

    CAS  Google Scholar 

  31. V. Jones, J. E. Grey, and K. G. Harding, BMJ, 332, 777 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  32. M. Georgescu, M. C. Chifiriuc, L. Marutescu, I. Gheorghe, V. Lazar, A. Bolocan, and A. Bertesteanu, Curr. Org. Chem., 21, 53 (2017).

    Article  CAS  Google Scholar 

  33. R. M. Day, in Advanced Wound Repair Therapies, Woodhead Publishing Limited, Cambridge, 2011, pp 155–173.

    Book  Google Scholar 

  34. X. Liu and G. Jia, J. Mater. Sci. Eng., 7, 100454 (2018).

    Google Scholar 

  35. P. Prabu, K. W. Kim, N. Dharmaraj, J. H. Park, M. S. Khil, and H. Y. Kim, Macromol. Res., 16, 303 (2008).

    Article  CAS  Google Scholar 

  36. S. Huang and X. Fu, J. Control. Release, 142, 149 (2010).

    Article  CAS  PubMed  Google Scholar 

  37. G. D. Mogoşanu and A. M. Grumezescu, Int. J. Pharm., 463, 127 (2014).

    Article  PubMed  CAS  Google Scholar 

  38. T. Wu, Y. Li, and D. S. Lee, Macromol. Res., 25, 480 (2017).

    Article  CAS  Google Scholar 

  39. H. Seddiqi, E. Oliaei, H. Honarkar, J. Jin, L. C. Geonzon, R. G. Bacabac, and J. Klein-Nulend, Cellulose, 28, 1893 (2021).

    Article  CAS  Google Scholar 

  40. I. Orlando and I. Roy, in Cellulose-Based Superabsorbent Hydrogels, Springer, Cham, 2019, pp 1131–1148.

    Book  Google Scholar 

  41. R. Portela, C. R. Leal, P. L. Almeida, and R. G. Sobral, Microb. Biotechnol., 12, 586 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. A. Khalid, H. Ullah, M. Ul-Islam, R. Khan, S. Khan, F. Ahmad, T. Khan, and F. Wahid, RSC Adv., 7, 47662 (2017).

    Article  CAS  Google Scholar 

  43. P. Basu, U. Narendrakumar, R. Arunachalam, S. Devi, and I. Manjubala, ACS Omega, 3, 12622 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. L. R. Bennison, C. N. Miller, R. J. Summers, A. M. B. Minnis, G. Sussman, and W. McGuiness, Wound Practice and Research, 25, 63 (2017).

    Google Scholar 

  45. K. Azuma, R. Izumi, T. Osaki, S. Ifuku, M. Morimoto, H. Saimoto, S. Minami, and Y. Okamoto, J. Funct. Biomater., 6, 104 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. H. Ueno, T. Mori, and T. Fujinaga, Adv. Drug Deliv. Rev., 52, 105 (2001).

    Article  CAS  PubMed  Google Scholar 

  47. E. I. Rabea, M. E.-T. Badawy, C. V. Stevens, G. Smagghe, and W. Steurbaut, Biomacromolecules, 4, 1457 (2003).

    Article  CAS  PubMed  Google Scholar 

  48. S. Abbaszadeh, M. Rashidipour, P. Khosravi, S. Shahryarhesami, B. Ashrafi, M. Kaviani, and M. M. Sarabi, Int. J. Nanomedicine, 15, 5963 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. M. Rashidipour, B. Ashrafi, M. R. Nikbakht, S. Veiskarami, M. Taherikalani, and S. Soroush, Prep. Biochem. Biotechnol., 51, 971 (2021).

    Article  CAS  PubMed  Google Scholar 

  50. P. Feng, Y. Luo, C. Ke, H. Qiu, W. Wang, Y. Zhu, R. Hou, L. Xu, and S. Wu, Front. Bioeng. Biotechnol., 9, 650598 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  51. M. A. Matica, F. L. Aachmann, A. Tøndervik, H. Sletta, and V. Ostafe, Int. J. Mol. Sci., 20, 5889 (2019).

    Article  CAS  PubMed Central  Google Scholar 

  52. Z. Değim, N. Celebi, H. Sayan, A. Babül, D. Erdoğan, and G. Take, Amino Acids, 22, 187 (2002).

    Article  PubMed  Google Scholar 

  53. H. Xu, Z. Fang, W. Tian, Y. Wang, Q. Ye, L. Zhang, and J. Cai, Adv. Mater., 30, e1801100 (2018).

    Article  CAS  Google Scholar 

  54. S. Thomas, J. Wound Care, 9, 56 (2000).

    Article  CAS  PubMed  Google Scholar 

  55. J. Boateng and O. Catanzano, J. Pharm. Sci., 104, 3653 (2015).

    Article  CAS  PubMed  Google Scholar 

  56. J. Sayag, S. Meaume, and S. Bohbot, J. Wound Care, 5, 357 (1996).

    Article  PubMed  Google Scholar 

  57. R. Raguvaran, B. K. Manuja, M. Chopra, R. Thakur, T. Anand, A. Kalia, and A. Manuja, Int. J. Biol. Macromol., 96, 185 (2017).

    Article  CAS  PubMed  Google Scholar 

  58. Z. Ahmadian, A. R. Dargahi, K. Musaie, and M. R. Eskandari, Pharm. Sci., DOI: https://doi.org/10.34172/PS.2021.65 (2022).

  59. Y. Kawano, V. Patrulea, E. Sublet, G. Borchard, T. Iyoda, R. Kageyama, A. Morita, S. Seino, H. Yoshida, O. Jordan, and T. Hanawa, Pharmaceuticals (Basel), 14, 301 (2021).

    Article  CAS  Google Scholar 

  60. C. Longinotti, Burns Trauma, 2, 162 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  61. D. Presti and J. E. Scott, Cell Biochem. Funct., 12, 281 (1994).

    Article  CAS  PubMed  Google Scholar 

  62. M. G. Neuman, R. M. Nanau, L. Oruña-Sanchez, and G. Coto, J. Pharm. Pharm. Sci., 18, 53 (2015).

    Article  CAS  PubMed  Google Scholar 

  63. P. Pirnazar, L. Wolinsky, S. Nachnani, S. Haake, A. Pilloni, and G. W. Bernard, J. Periodontol., 70, 370 (1999).

    Article  CAS  PubMed  Google Scholar 

  64. M. Edmonds and A. Foster, Diabet Foot, 3, 29 (2000).

    Google Scholar 

  65. H. Ying J. Zhou, M. Wang, D. Su, Q. Ma, G. Lv, and J. Chen, Mater. Sci. Eng. C: Mater. Biol. Appl., 101, 487 (2019).

    Article  CAS  Google Scholar 

  66. M. Mir, M. N. Ali, A. Barakullah, A. Gulzar, M. Arshad, S. Fatima, and M. Asad, Prog. Biomater., 7, 1 (2018).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  67. P. Supaphol, O. Suwantong, P. Sangsanoh, S. Srinivasan, R. Jayakumar, and S. V. Nair, in Biomedical Applications of Polymeric Nanofibers, Springer, Berlin, Heidelberg, 2011, pp 213–239.

    Book  Google Scholar 

  68. M. Sinha, R. M. Banik, C. Haldar, and P. Maiti, J. Porous Mater., 20, 799 (2013).

    Article  CAS  Google Scholar 

  69. P. Y. Lee, E. Cobain, J. Huard, and L. Huang, Mol. Ther., 15, 1189 (2007).

    Article  CAS  PubMed  Google Scholar 

  70. J. Zhu, F. Li, X. Wang, J. Yu, and D. Wu, ACS Appl. Mater. Interfaces, 10, 13304 (2018).

    Article  CAS  PubMed  Google Scholar 

  71. A. Kumar and S. S. Han, Int. J. Polym. Mater., 66, 159 (2017).

    Article  CAS  Google Scholar 

  72. J. K. Li, N. Wang, and X. S. Wu, J. Control. Release, 56, 117 (1998).

    Article  CAS  PubMed  Google Scholar 

  73. C. A. Finch, Ed., in Polyvinyl Alcohol; Properties and Applications, John Wiley & Sons, London, 1973, p 622.

    Google Scholar 

  74. M. D. Figueroa-Pizano, I. Vélaz, and M. E. Martínez-Barbosa, J. Vis. Exp., 155, e59636 (2020).

    Google Scholar 

  75. J. Zhang, S. Wang, Z. Zhao, D. Si, H. Zhou, M. Yang, and X. Wang, Macromol. Res., 28, 1127 (2020).

    Article  CAS  Google Scholar 

  76. A. Fahmy, E. A. Kamoun, R. El-Eisawy, E. M. El-Fakharany, T. H. Taha, B. K. El-Damhougy, and F. Abdelhai, J. Braz. Chem. Soc., 26, 1466 (2015).

    CAS  Google Scholar 

  77. T. M. Don, C. F. King, W. Y. Chiu, and C. A. Peng, Carbohydr. Polym., 63, 331 (2006).

    Article  CAS  Google Scholar 

  78. K. Tarun and N. Gobi, Indian J. Fibre Text. Res., 37, 127 (2012).

    CAS  Google Scholar 

  79. M. Bahadoran, A. Shamloo, and Y. D. Nokoorani, Sci. Rep., 10, 7342 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. S. Kumbar, C. Laurencin, and M. Deng, Natural and Synthetic Biomedical Polymers, 1st ed., Elsevier, Burlington, 2014.

    Google Scholar 

  81. A. E. Hafeman, B. Li, T. Yoshii, K. Zienkiewicz, J. M. Davidson, and S. A. Guelcher, Pharm. Res., 25, 2387 (2008).

    Article  CAS  PubMed  Google Scholar 

  82. M. Rottmar, M. Richter, X. Mäder, K. Grieder, K. Nuss, A. Karol, B. von Rechenberg, E. Zimmermann, S. Buser, A. Dobmann, J. Blume, and A. Bruinink, Sci. Technol. Adv. Mater., 16, 034606 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  83. H. J. Shao, Y. T. Lee, C. S. Chen, J. H. Wang, and T. H. Young, Biomaterials, 31, 4695 (2010).

    Article  CAS  PubMed  Google Scholar 

  84. N. Sultana and K. T. Hayat, J. BioNanoScience, 7, 169 (2013).

    Article  CAS  Google Scholar 

  85. M. O. Christen and F. Vercesi, Clin. Cosmet. Investig. Dermatol., 13, 31 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. H. T. Bui, O. H. Chung, J. D. Cruz, and J. S. Park, Macromol. Res., 22, 1288 (2014).

    Article  CAS  Google Scholar 

  87. A. Chanda, J. Adhikari, A. Ghosh, S. R. Chowdhury, S. Thomas, P. Datta, and P. Saha, Int. J. Biol. Macromol., 116, 774 (2018).

    Article  CAS  PubMed  Google Scholar 

  88. J. Kundu, J. H. Shim, J. Jang, S. W. Kim, and D. W. Cho, J. Tissue Eng. Regen. Med., 9, 1286 (2015).

    Article  CAS  PubMed  Google Scholar 

  89. E. J. Chong, T. T. Phan, I. J. Lim, Y. Z. Zhang, B. H. Bay, S. Ramakrishna, and C. T. Lim, Acta Biomater., 3, 321 (2007).

    Article  CAS  PubMed  Google Scholar 

  90. R. Thomas, K. R. Soumya, J. Mathew, and E. K. Radhakrishnan, Appl. Biochem. Biotechnol., 176, 2213 (2015).

    Article  CAS  PubMed  Google Scholar 

  91. B. Joseph, R. Augustine, N. Kalarikkal, S. Thomas, B. Seantier, and Y. Grohense, Mater. Today Commun., 19, 319 (2019).

    Article  CAS  Google Scholar 

  92. S. G. Hong and G. H. Kim, Bioprocess Biosyst. Eng., 36, 205 (2013).

    Article  CAS  PubMed  Google Scholar 

  93. C. Xuan, L. Hao, X. Liu, Y. Zhu, H. Yang, Y. Ren, L. Wang, T. Fujie, H. Wu, Y. Chen, X. Shi, and C. Mao, Biomaterials, 252, 120018 (2020).

    Article  CAS  PubMed  Google Scholar 

  94. P. Hubner, N. R. Marcilio, and I. C. Tessaro, J. Biomater. Appl., 3, 682 (2021).

    Article  CAS  Google Scholar 

  95. H. Chopra, S. Bibi, S. Kumar, M. S. Khan, P. Kumar, and I. Singh, Gels, 8, 111 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. M. M. Hasan, M. F. Uddin, N. Zabin, M. S. Shakil, M. Alam, F. J. Achal, M. H. Ara Begum, M. S. Hossen, M. A. Hasan, and M. M. Morshed, Int. J. Biomater., 2021, 4877344 (2021).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  97. G. D. Kang, K. H. Lee, C. S. Ki, J. H. Nahm, and Y. H. Park, Macromol. Res., 12, 534 (2004).

    Article  CAS  Google Scholar 

  98. A. Vijayan and G. Kumar, Sci. Rep., 9, 19165 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. P. Wang, Y. Kim, and C. Soh, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, The 27th Annual International Conference of the IEEE-EMBS, Shanghai, 2006.

  100. A. Eskandarinia, A. Kefayat, M. Agheb, M. Rafienia, M. A. Baghbadorani, S. Navid, K. Ebrahimpour, D. Khodabakhshi, and F. Ghahremani, Sci. Rep., 10, 3063 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. J. Kim and C. M. Lee, Macromol. Res., 26, 1219 (2018).

    Article  CAS  Google Scholar 

  102. F. Poustchi, H. Amani, Z. Ahmadian, S. V. Niknezhad, S. Mehrabi, H. A. Santos, and M. A. Shahbazi, Adv. Healthc. Mater., 10, e2001571 (2021).

    Article  PubMed  CAS  Google Scholar 

  103. Z. Ahmadian, A. Correia, M. Hasany, P. Figueiredo, F. Dobakhti, M. R. Eskandari, S. H. Hosseini, R. Abiri, S. Khorshid, J. Hirvonen, H. A. Santos, and M. A. Shahbazi, Adv. Healthc. Mater., 10, e2001122 (2021).

    Article  PubMed  CAS  Google Scholar 

  104. P. Kuchaiyaphum, C. Chotichayapong, N. Butwong, and W. Bua-ngern, Macromol. Res., 28, 844 (2020).

    Article  CAS  Google Scholar 

  105. J. Boateng, Ed., Therapeutic Dressings and Wound Healing Applications, John Wiley & Sons, Chichester, 2020.

    Google Scholar 

  106. Y. Yao, A. Zhang, C. Yuan, X. Chen, and Y. Liu, Biomater. Sci., 9, 4523 (2021).

    Article  CAS  PubMed  Google Scholar 

  107. C. T. Hess, Adv. Skin Wound Care, 13, 131 (2000).

    CAS  PubMed  Google Scholar 

  108. E. A. Kamoun, E. S. Kenawy, and X. Chen, J. Adv. Res., 8, 217 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Z. Li, F. Zhou, Z. Li, S. Lin, L. Chen, L. Liu, and Y. Chen, ACS Appl. Mater. Interfaces, 10, 25194 (2018).

    Article  CAS  PubMed  Google Scholar 

  110. M. A. Fonder, G. S. Lazarus, D. A. Cowan, B. Aronson-Cook, A. R. Kohli, and A. J. Mamelak, J. Am. Acad. Dermatol., 58, 185 (2008).

    Article  PubMed  Google Scholar 

  111. S. Wang, K. Liu, X. Yao, and L. Jiang, Chem. Rev., 115, 8230 (2015).

    Article  CAS  PubMed  Google Scholar 

  112. X. Yao, G. Zhu, P. Zhu, J. Ma, W. Chen, Z. Liu, and T. Kong, Adv. Funct. Mater., 30, 1909389 (2020).

    Article  CAS  Google Scholar 

  113. S. Thomas, Int. Wound J., 5, 602 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  114. T. S. Stashak, E. Farstvedt, and A. Othic, Clin. Tech. Equ. Pract., 3, 148 (2004).

    Article  Google Scholar 

  115. J. Lei, L. Sun, P. Li, C. Zhu, Z. Lin, V. Mackey, D. H. Coy, and Q. He, Heal. Sci. J., 13, 662 (2019).

    Google Scholar 

  116. H. E. Thu, M. H. Zulfakar, and S. F. Ng, Int. J. Pharm., 434, 375 (2012).

    Article  CAS  PubMed  Google Scholar 

  117. G. Schoukens, in Advanced Textiles for Wound Care, 2nd ed., Elsevier, Cambridge, 2019, pp 135–167.

    Book  Google Scholar 

  118. A. Agarwal, J. F. McAnulty, M. J. Schurr, C. J. Murphy, and N. L. Abbott, in Advanced Wound Repair Therapies, Woodhead Publishing Limited, Cambridge, 2011, pp 186–208.

    Book  Google Scholar 

  119. S. A. Eming, T. Krieg, and J. M. Davidson, J. Invest. Dermatol., 127, 514 (2007).

    Article  CAS  PubMed  Google Scholar 

  120. M. De Mattei, A. Ongaro, S. Magaldi, D. Gemmati, A. Legnaro, A. Palazzo, F. Masieri, A. Pellati, L. Catozzi, A. Caruso, and P. Zamboni, Dermatol. Surg., 34, 347 (2008).

    CAS  PubMed  Google Scholar 

  121. S. M. Lee, I. K. Park, Y. S. Kim, H. J. Kim, H. Moon, S. Mueller, and Y. I. Jeong, Biomater. Res., 20, 15 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  122. S. Thomas, J. Wound Care, 5, 271 (1996).

    Article  CAS  PubMed  Google Scholar 

  123. K. Yasuda, M. Ogushi, A. Nakashima, Y. Nakano, and K. Suzuki, In Vivo, 32, 799 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  124. R. Pereira, A. Carvalho, D. C. Vaz, M. H. Gil, A. Mendes, and P. Bártolo, Int. J. Biol. Macromol., 52, 221 (2013).

    Article  CAS  PubMed  Google Scholar 

  125. H. Shrimali, U. K. Mandal, M. Nivsarkar, and N. Shrivastava, Future J. Pharm. Sci., 5, 12 (2019).

    Article  Google Scholar 

  126. H. J. Yoo and H. D. Kim, J. Appl. Polym. Sci., 107, 331 (2008).

    Article  CAS  Google Scholar 

  127. R. James, U. S. Toti, C. T. Laurencin, and S. G. Kumbar, Methods Mol. Biol., 726, 243 (2011).

    Article  CAS  PubMed  Google Scholar 

  128. M. Ramalingam and S. Ramakrishna, in Nanofiber Composites for Biomedical Applications, Elsevier, Cambridge, 2017, pp 3–29.

    Book  Google Scholar 

  129. M. Zamani, M. P. Prabhakaran, and S. Ramakrishna, Int. J. Nanomedicine, 8, 2997 (2013).

    PubMed  PubMed Central  Google Scholar 

  130. S. Thenmozhi, N. Dharmaraj, K. Kadirvelu, and H. Y. Kim, Mater. Sci. Eng. B, 217, 36 (2017).

    Article  CAS  Google Scholar 

  131. Z. Sun, E. Zussman, A. L. Yarin, J. H. Wendorff, and A. Greiner, Adv. Mater., 15, 1929 (2003).

    Article  CAS  Google Scholar 

  132. S. Sattari, A. D. Tehrani, M. Adeli, K. Soleimani, and M. Rashidipour, Int. J. Biol. Macromol., 156, 1126 (2020).

    Article  CAS  PubMed  Google Scholar 

  133. S. M. Jung, S. K. Min, H. C. Lee, Y. S. Kwon, M. H. Jung, and H. S. Shin, J. Nanomater., 2016, 6135727 (2016).

    Google Scholar 

  134. E. G. Lemraski, H. Jahangirian, M. Dashti, E. Khajehali, S. Sharafinia, R. Rafiee-Moghaddam, and T. J. Webster, Int. J. Nanomedicine, 16, 223 (2021).

    Article  Google Scholar 

  135. J. Dissemond, M. Witthoff, T. C. Brauns, D. Haberer, and M. Goos, Hautarzt, 54, 959 (2003).

    Article  CAS  PubMed  Google Scholar 

  136. M. Omidi, A. Yadegari, and L. Tayebi, RSC Adv., 7, 10638 (2017).

    Article  CAS  Google Scholar 

  137. E. Gianino, C. Miller, and J. Gilmore, Bioengineering (Basel), 5, 51 (2018).

    Article  CAS  Google Scholar 

  138. R. Dong and B. Guo, Nano Today, 41, 101290 (2021).

    Article  CAS  Google Scholar 

  139. H. Wei, S. X. Cheng, S. X. Xian, X. Z. Zhang, and R. X. Zhuo, Prog. Polym. Sci., 34, 893 (2009).

    Article  CAS  Google Scholar 

  140. L. Jiang and S. C. J. Loo, ACS Appl. Bio Mater., 4, 3849 (2020).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  141. Q. Pang, D. Lou, S. Li, G. Wang, B. Qiao, S. Dong, L. Ma, C. Gao, and Z. Wu, Adv. Sci. (Weinh), 7, 1902673 (2020).

    Article  CAS  Google Scholar 

  142. R. D. Forrest, J. R. Soc. Med., 75, 198 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  143. R. Yaghoobi, A. Kazerouni, and O. Kazerouni, Jundishapur J. Nat. Pharm. Prod., 8, 100 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  144. P. C. Molan and T. Rhodes, Wounds, 27, 141 (2015).

    PubMed  Google Scholar 

  145. P. C. Molan, Bee World, 73, 5 (1992).

    Article  Google Scholar 

  146. A. C. Yilmaz and D. Aygin, Complement. Ther. Med., 51, 102388 (2020).

    Article  PubMed  Google Scholar 

  147. J. A. Stewart, O. L. McGrane, and I. S. Wedmore, Wilderness Environ. Med., 25, 103 (2014).

    Article  PubMed  Google Scholar 

  148. S. K. Saikaly and A. Khachemoune, Am. J. Clin. Dermatol., 18, 237 (2017).

    Article  PubMed  Google Scholar 

  149. K. Lay-Flurrie, Br. J. Nurs., 17, S30, S32 (2008).

    Article  PubMed  Google Scholar 

  150. R. M. Zohdi, Z. A. B. Zakaria, N. Yusof, N. M. Mustapha, and M. N. H. Abdullah, Evid. Based Complement. Alternat. Med., 2012, 843025 (2012).

    Google Scholar 

  151. N. K. Ghodela, P. Prasad, V. Kumar, and T. S. Dudhamal, Global J. Res. Med. Plants Indigen. Med., 6, 89 (2017).

    Google Scholar 

  152. J. M. Rosa, L. B. Bonato, C. B. Mancuso, L. Martinelli, M. H. Okura, G. R. P. Malpass, and A. C. Granato, Ciênc Rural, 48, e20170740 (2018).

    CAS  Google Scholar 

  153. K. N. Ali, H. F. Marif, H. S. Raoof, S. M. A. Hassan, and D. O. Ramzi, Indian J. Forensic. Med. Toxicol., 15, 2012 (2021).

    CAS  Google Scholar 

  154. D. Masson-Meyers, C. S. Enwemeka, V. Bumah, and M. A. Frade, Int. J. Appl. Microbiol. Sci., 2, 9 (2013).

    Google Scholar 

  155. Z. Moudi, M. Edozahi, S. A. Emami, J. Asili, and M. S. Pour, J. Ethnopharmacol., 214, 225 (2018).

    Article  CAS  PubMed  Google Scholar 

  156. E. Napoli, A. Boudjelal, A. Benkhaled, S. Chabane, D. Gentile, and G. Ruberto, J. Essent. Oil Res., 33, 464 (2021).

    Article  CAS  Google Scholar 

  157. D. Masson-Meyers, T. Andrade, S. N. Leite, and M. Frade, Int. J. Nat. Prod. Sci., 3, 10 (2013).

    Google Scholar 

  158. A. Mallik, D. Goupalea, H. Dhongadeb, and S. Nayak, Pharm. Lett., 2, 457 (2010).

    CAS  Google Scholar 

  159. F. Haghdoost, M. M. B. Mahdavi, A. Zandifar, M. H. Sanei, B. Zolfaghari, and S. H. Javanmard, Evid. Based Complement. Alternat. Med., 2013, 893425 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  160. A. Rojewska, A. Karewicz, K. Boczkaja, K. Wolski, M. Kępczyński, S. Zapotoczny, and M. Nowakowska, Eur. Polym. J., 96, 200 (2017).

    Article  CAS  Google Scholar 

  161. N. S. V. Capanema, A. A. P. Mansur, A. C. de Jesus, S. M. Carvalho, L. C. de Oliveira, and H. S. Mansur, Int. J. Biol. Macromol., 106, 1218 (2018).

    Article  CAS  PubMed  Google Scholar 

  162. J. Kiiskinen, A. Merivaara, T. Hakkarainen, M. Kääriäinen, S. Miettinen, M. Yliperttula, and R. Koivuniemi, Stem. Cell. Res. Ther, 10, 292 (2019).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  163. N. S. V. Capanema, H. S. Mansur, C. P. Ramos, A. P. Lage, M. Sandhra, S. M. Carvalho, and H. S. Mansur, J. Appl. Polym. Sci., 135, 45812 (2018).

    Article  CAS  Google Scholar 

  164. P. Wutticharoenmongkol, P. Hannirojram, and P. Nuthong, Polym. Adv. Technol., 30, 1135 (2019).

    Article  CAS  Google Scholar 

  165. S. Napavichayanun, S. Ampawong, T. Harnsilpong, A. Angspatt, and P. Aramwit, Arch. Dermatol. Res., 310, 795 (2018).

    Article  PubMed  Google Scholar 

  166. M. Liang, Z. Chen, F. Wang, L. Liu, R. Wei, and M. Zhang, J. Biomed. Mater. Res. B: Appl. Biomater., 107, 1471 (2019).

    Article  CAS  Google Scholar 

  167. I. Sulaeva, H. Hettegger, A. Bergen, C. Rohrer, M. Kostic, J. Konnerth, T. Rosenau, and A. Potthast, Mater. Sci. Eng. C: Mater. Biol. Appl., 110, 110619 (2020).

    Article  CAS  Google Scholar 

  168. A. Ullah, S. Ullah, M. Q. Khan, M. Hashmi, P. D. Nam, Y. Kato, Y. Tamada, and I. S. Kim, Int. J. Biol. Macromol., 155, 479 (2020).

    Article  CAS  PubMed  Google Scholar 

  169. N. Akhavan-Kharazian and H. Izadi-Vasafi, Int. J. Biol. Macromol., 133, 881 (2019).

    Article  CAS  PubMed  Google Scholar 

  170. D. Liang, Z. Lu, H. Yang, J. Gao, and R. Chen, ACS Appl. Mater. Interfaces, 8, 3958 (2016).

    Article  CAS  PubMed  Google Scholar 

  171. W. A. Sarhan, H. M. Azzazy, and I. M. El-Sherbiny, ACS Appl. Mater. Interfaces, 8, 6379 (2016).

    Article  CAS  PubMed  Google Scholar 

  172. S. Anjum, A. Arora, M. S. Alam, and B. Gupta, Int. J. Pharm., 508, 92 (2016).

    Article  CAS  PubMed  Google Scholar 

  173. A. M. Abdel-Mohsen, R. M. Abdel-Rahman, I. Kubena, L. Kobera, Z. Spotz, M. Zboncak, R. Prikryl, J. Brus, and J. Jancar, Carbohydr. Polym., 230, 115708 (2020).

    Article  CAS  PubMed  Google Scholar 

  174. S. Wang, F. Yan, P. Ren, Y. Li, Q. Wu, X. Fang, F. Chen, and C. Wang, Int. J. Biol. Macromol., 158, 9 (2020).

    Article  CAS  PubMed  Google Scholar 

  175. J. S. Oh and E. J. Lee, Mater. Sci. Eng. C: Mater. Biol. Appl., 103, 109815 (2019).

    Article  CAS  Google Scholar 

  176. W. Y. Zhao, Q. Q. Fang, X. F. Wang, X. W. Wang, T. Zhang, B. H. Shi, B. Zheng, D. D. Zhang, Y. Y. Hu, L. Ma, and W. Q. Tan, Wound Repair Regen., 28, 326 (2019).

    Article  PubMed  Google Scholar 

  177. T. Lim, Q. Tang, Z. Zhu, X. Wei, and C. Zhang, J. Biomed. Mater. Res. A, 108, 2111 (2020).

    Article  CAS  PubMed  Google Scholar 

  178. A. N. Khodja, M. Mahlous, D. Tahtat, S. Benamer, S. L. Youcef, H. Chader, L. Mouhoub, M. Sedgelmaci, N. Ammi, M. B. Mansouri, and S. Mameri, Burns, 39, 98 (2013).

    Article  Google Scholar 

  179. M. H. Najar, M. Minaiyan, and A. Taheri, J. Biomater. Appl., 32, 689 (2018).

    Article  CAS  Google Scholar 

  180. H. Kaygusuz, E. Torlak, G. Akin-Evingür, İ. Özen, R. von Klitzing, and F. B. Erim, Int. J. Biol. Macromol., 105, 1161 (2017).

    Article  CAS  PubMed  Google Scholar 

  181. F. Cheng, C. Liu, X. Wei, T. Yan, H. Li, J. He, and Y. Huang, ACS Sustain. Chem. Eng., 5, 3819 (2017).

    Article  CAS  Google Scholar 

  182. M. Elmowafy, K. Shalaby, A. Salama, G. M. Soliman, N. K. Alruwaili, E. M. Mostafa, E. F. Mohammed, A. E. G. A. Moustafa, and A. Zafar, J. Pharm. Pharmacol., 71, 774 (2019).

    Article  CAS  PubMed  Google Scholar 

  183. J. W. Kim, E. H. Kim, G. D. Han, S. H. Noh, D. G. Pyun, Y. Ito, J. W. Nah, J. G. Lee, and T. H. Son, J. Ind. Eng. Chem., 54, 350 (2017).

    Article  CAS  Google Scholar 

  184. C. Z. Bueno and A. M. Moraes, Mater. Sci. Eng. C: Mater. Biol. Appl., 93, 671 (2018).

    Article  CAS  Google Scholar 

  185. M. Rezvanian, M. C. I. M. Amin, and S. F. Ng, Carbohydr. Polym., 137, 295 (2016).

    Article  CAS  PubMed  Google Scholar 

  186. A. Y. Koga, A. V. Pereira, L. C. Lipinski, and M. R. Oliveira, J. Biomater. Appl., 32, 1212 (2018).

    Article  CAS  PubMed  Google Scholar 

  187. Y. Chen, H. Qiu, M. Dong, B. Cheng, Y. Jin, Z. Tong, P. Li, S. Li, and Z. Yang, Carbohydr Polym., 206, 435 (2019).

    Article  CAS  PubMed  Google Scholar 

  188. A. Ehterami, M. Salehi, S. Farzamfar, H. Samadian, A. Vaez, S. Ghorbani, J. Ai, and H. Sahrapeyma, J. Drug Deliv. Sci. Technol., 51, 204 (2019).

    Article  CAS  Google Scholar 

  189. Y. Duan, K. Li, H. Wang, T. Wu, Y. Zhao, H. Li, H. Tang, and W. Yang, Carbohydr Polym., 238, 116195 (2020).

    Article  CAS  PubMed  Google Scholar 

  190. A. Eskandarinia, A. Kefayat, M. Rafienia, M. Agheb, S. Navid, and K. Ebrahimpour, Carbohydr. Polym., 216, 25 (2019).

    Article  CAS  PubMed  Google Scholar 

  191. T. W. Wang, J. S. Sun, H. C. Wu, Y. H. Tsuang, W. H. Wang, and F. H. Lin, Biomaterials, 27, 5689 (2006).

    Article  CAS  PubMed  Google Scholar 

  192. M. Mahedia, N. Shah, and B. Amirlak, Plast. Reconstr. Surg. Glob. Open, 4, e791 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  193. M. R. El-Aassar, O. M. Ibrahim, M. M. G. Fouda, N. G. El-Beheri, and M. M. Agwa, Carbohydr. Polym., 238, 116175 (2020).

    Article  CAS  PubMed  Google Scholar 

  194. Z. Hadisi, T. Walsh, S. M. H. Dabiri, A. Seyfoori, D. Hamdi, B. Mirani, E. Pagan, A. Jardim, and M. Akbari, Macromol. Biosci., 20, e1900328 (2020).

    Article  PubMed  CAS  Google Scholar 

  195. Y. Bu, L. Zhang, G. Sun, F. Sun, J. Liu, F. Yang, P. Tang, and D. Wu, Adv. Mater., 31, e1901580 (2019).

    Article  PubMed  CAS  Google Scholar 

  196. X. Zhao, H. Wu, B. Guo, R. Dong, Y. Qiu, and P. X. Ma, Biomaterials, 122, 34 (2017).

    Article  CAS  PubMed  Google Scholar 

  197. M. Movahedi, A. Asefnejad, M. Rafienia, and M. T. Khorasani, Int. J. Biol. Macromol., 146, 627 (2020).

    Article  CAS  PubMed  Google Scholar 

  198. B. Li, J. M. Davidson, and S. A. Guelcher, Biomaterials, 30, 3486 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  199. J. G. Lundin, C. L. McGann, G. C. Daniels, B. C. Streifel, and J. H. Wynne, Mater. Sci. Eng. C: Mater. Biol. Appl., 79, 702 (2017).

    Article  CAS  Google Scholar 

  200. R. Niranjan, M. Kaushik, R. T. Selvi, J. Prakash, K. S. Venkataprasanna, D. Prema, B. Pannerselvam, and G. D. Venkatasubbu, Int. J. Biol. Macromol., 138, 704 (2019).

    Article  CAS  PubMed  Google Scholar 

  201. Y. Liu, Q. Zhang, N. Zhou, J. Tan, J. Ashley, W. Wang, F. Wu, J. Shen, and M. Zhang, Chem. Eng. Sci., 395, 125059 (2020).

    Article  CAS  Google Scholar 

  202. K. Bialik-Wąs, K. Pluta, D. Malina, and T. M. Majka, Int. J. Polym. Mater. Polym. Biomater., 70, 195 (2021).

    Article  CAS  Google Scholar 

  203. N. N. Costa, L. de Faria Lopes, D. F. Ferreira, E. M. L. de Prado, J. A. Severi, J. A. Resende, F. de Paula Careta, M. C. P. Ferreira, L. G. Carreira, S. O. L. de Souza, M. A. P. Cotrim, T. Boeing, S. F. de Andrade, R. L. Oréfice, and J. C. O. Villanova, Mater. Sci. Eng. C: Mater. Biol. Appl., 109, 110643 (2020).

    Article  CAS  Google Scholar 

  204. C. Xuan, L. Hao, X. Liu, Y. Zhu, H. Yang, Y. Ren, L. Wang, T. Fujie, H. Wu, Y. Chen, X. Shi, and C. Mao, Biomaterials, 252, 120018 (2020).

    Article  CAS  PubMed  Google Scholar 

  205. A. P. Rameshbabu, S. Datta, K. Bankoti, E. Subramani, K. Chaudhury, V. Lalzawmliana, S. K. Nandi, and S. Dhara, J. Mater. Chem. B, 6, 6767 (2018).

    Article  CAS  PubMed  Google Scholar 

  206. Q. Pang, D. Lou, S. Li, G. Wang, B. Qiao, S. Dong, L. Ma, C. Gao, and Z. Wu, Adv. Sci. (Weinh), 7, 1902673 (2020).

    Article  CAS  Google Scholar 

  207. K. M. Zepon, M. M. Martins, M. S. Marques, J. M. Heckler, F. Dal Pont Morisso, M. G. Moreira, A. L. Ziulkoski, and L. A. Kanis, Carbohydr. Polym., 206, 362 (2019).

    Article  CAS  PubMed  Google Scholar 

  208. Y. Zhao, Z. Li, S. Song, K. Yang, H. Liu, Z. Yang, J. Wang, B. Yang, and Q. Lin, Adv. Funct. Mater., 29, 1901474 (2019).

    Article  CAS  Google Scholar 

  209. J. Zhou, D. Yao, Z. Qian, S. Hou, L. Li, A. T. A. Jenkins, and Y. Fan, Biomaterials, 161, 11 (2018).

    Article  CAS  PubMed  Google Scholar 

  210. A. S. Montaser, M. Rehan, and M. E. El-Naggar, Int. J. Biol. Macromol., 124, 1016 (2019).

    Article  CAS  PubMed  Google Scholar 

  211. Haryanto and A. N. Aini, IOP Conf. Ser. Mater. Sci. Eng., 403, 012014 (2018).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran

    Zainab Ahmadian

  2. Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

    Hasan Adiban & Mohammad Reza Eskandari

  3. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran

    Marzieh Rashidipour

  4. Environmental Health Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran

    Marzieh Rashidipour

  5. Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan, Iran

    Mohammad Reza Eskandari

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  1. Zainab Ahmadian
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  2. Hasan Adiban
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Correspondence to Mohammad Reza Eskandari.

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Acknowledgment: This study was funded by a Research Grant from Zanjan University of Medical Sciences, Deputy of Research (No. A-12-1296-2) with the ethical code of IR.ZUMS.REC.1398.234.

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Ahmadian, Z., Adiban, H., Rashidipour, M. et al. Bioactive Natural and Synthetic Polymers for Wound Repair. Macromol. Res. 30, 495–526 (2022). https://doi.org/10.1007/s13233-022-0062-4

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