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Natural flavonoids as potential therapeutics in the management of Alzheimer’s disease: a review

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Abstract

Alzheimer’s disease (AD) is an age-dependent neurodegenerative disorder which is associated with the accumulation of proteotoxic Aβ peptides, and pathologically characterized by the deposition of Aβ-enriched plaques and neurofibrillary tangles. Given the social and economic burden caused by the rising frequency of AD, there is an urgent need for the development of appropriate therapeutics. Natural compounds are gaining popularity as alternatives to synthetic drugs due to their neuroprotective properties and higher biocompatibility. While natural compound’s therapeutic effects for AD have been recently investigated in numerous in vitro and in vivo studies, only few have developed to clinical trials. The present review aims to provide a brief overview of the therapeutic effects, new insights, and upcoming perspectives of the preclinical and clinical trials of flavonoids for the treatment of Alzheimer’s disease.

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  1. Phuong-Trang Nguyen-Thi and Giau Van Vo equally contributed.

Authors and Affiliations

  1. Faculty of Pharmacy, HUTECH University, Ho Chi Minh City, 700000, Vietnam

    Phuong-Trang Nguyen-Thi

  2. Department of Sports Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, 100000, Vietnam

    Tuong Kha Vo

  3. Institute for Global Health Innovations, Duy Tan University, Da Nang, 550000, Vietnam

    Thi Hong Trang Pham

  4. Faculty of Pharmacy, Duy Tan University, Da Nang, 550000, Vietnam

    Thi Hong Trang Pham

  5. Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City, Ho Chi Minh City, 71420, Vietnam

    Thuy Trang Nguyen

  6. Department of Biomedical Engineering, School of Medicine, Vietnam National University – Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam

    Giau Van Vo

  7. Research Center for Genetics and Reproductive Health (CGRH), School of Medicine, Vietnam National University, Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 70000, Vietnam

    Giau Van Vo

  8. Vietnam National University – Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam

    Giau Van Vo

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Nguyen-Thi, PT., Vo, T.K., Pham, T.H.T. et al. Natural flavonoids as potential therapeutics in the management of Alzheimer’s disease: a review. 3 Biotech 14, 68 (2024). https://doi.org/10.1007/s13205-024-03925-8

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