Abstract
Patients with psoriasis often complain of several linked disorders including autoimmune and cardiometabolic diseases. Understanding of molecular link between psoriasis and associated comorbidities would be of great interest at the point of patient care management. Integrative unbiased network approach, indicates significant unidirectional gene overlap between psoriasis and its associated comorbid condition including obesity (31 upregulated and 26 downregulated), ischemic stroke (14 upregulated and 2 downregulated), dyslipidaemia (5 upregulated, 5 downregulated), atherosclerosis (8 upregulated and 1 downregulated) and type II diabetes (5 upregulated, 5 downregulated). The analysis revealed substantial gene sharing among the different psoriasis-associated comorbidities. Molecular comorbidity index determining the strength of the interrelation between psoriasis and its comorbidities indicates prevalence of dyslipidaemia followed by type II diabetes among psoriasis patients. The Jaccard coefficient indices revealed psoriasis shared maximum number of biological pathways with dyslipidaemia followed by type 2 diabetes, ischemic stroke, obesity and atherosclerosis. Moreover, pathway annotation highlighted nearly 45 shared pathways amongst psoriasis and its comorbidities and a substantial number of shared pathways was found among multi-morbidities. Overall, the present study established conceivable link between psoriasis and comorbid diseases. The shared genes and overlapped pathways may be explored as a common productive target for psoriasis and its comorbid conditions.
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The relevant data is provided in the manuscript and in case some other data that supports the finding of this study is required, it is accessible from the corresponding authors (Dr. Neeraj Kumar and Dr. Dibyabhaba Pradhan) upon request.
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Acknowledgements
We acknowledge the financial support from the Indian Council of Medical Research, New Delhi [grant number: ISRM/12(117)/2020 (ID No. 2020-4900)] for conducting the study. We also acknowledge financial and administrative support from ICMR-National Institute of Pathology, New Delhi.
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SC is credited with designing, data acquisition, analysis, interpretation, drafting and revision of the script. NSK and RV is credited with critical inputs, interpretation, data acquisition and analysis. PS is credited with analysis and revision of the script. HS and AKJ contributed in analysis, interpretation and revision of the script. GT aided in data acquisition, drafting and revision of the script. DBP and NK aided with supervision, conceptualization, interpretation and analysis.
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Choudhary, S., Khan, N.S., Verma, R. et al. Exploring the molecular underpinning of psoriasis and its associated comorbidities through network approach: cross talks of genes and pathways. 3 Biotech 13, 130 (2023). https://doi.org/10.1007/s13205-023-03533-y
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DOI: https://doi.org/10.1007/s13205-023-03533-y