Abstract
Management of glycaemic response is perhaps the most critical part of antidiabetic therapy. Hypoglycaemia is an avoidable complication caused by conventional drugs used in the treatment of diabetes. It triggers commonly during the intensification of anti-hyperglycemic therapy used to render glycemic control in diabetic patients. The commercial oral hypoglycaemic drugs, insulin, herbal medicines and plant extracts are therefore used as a part of the treatment of diabetes. The demand for treating diabetes, through herbal and plant resources is due to their lesser adverse reactions and better phytochemical benefits. Corn silk has been shown to have anti-allergic, anti-inflammatory, and anti-hypertensive effects when extracted in various solvents. Corn silk has medicinal characteristics and has long been used as a traditional medicine in many nations, although the mechanism of action is unknown. The hypoglycaemic effects of corn silk are investigated in this review. The phytochemical components present in corn silk-like flavonoids, phenolics, terpenoids, tannins, sterols, and alkaloids are phytochemical components that have hypoglycemic activity and a mechanism for lowering blood glucose levels. There is a lack of a homogenized database on the hypoglycemic properties of corn silk thus the present review attempts to critically analyse it and provide specific recommendations of its doses.
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Abbreviations
- IDF :
-
International diabetes federation
- MEA:
-
Middle east & Africa
- APEJ:
-
Asia pacific excluding Japan
- GAE:
-
Gallic acid equivalent
- ABTS:
-
(2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)
- CS:
-
Corn silk
- NC:
-
Non-diabetic control
- DC:
-
Diabetic control
- LD:
-
Low dose
- HD:
-
High dose
- MD:
-
Medium dose
- PD:
-
Dimethylbiguanide
- GLUT4:
-
Glucose transporter type 4
- PECS:
-
Petroleum ether corn silk
- CECS :
-
Chloroform corn silk
- MECS:
-
Methanol corn silk
- AGE :
-
Advanced glycation end PRODUCTS
- HFD-STZ:
-
High fat diet streptozotocin
- POCS:
-
Corn silk polysaccharides
- DPPH:
-
2,2-Diphenyl-1-picrylhydrazyl.
- YMS-EA:
-
Ethyl acetate fraction
- ROS:
-
Reactive oxygen species
- PDX-1:
-
Pancreatic and duodenal homeobox
- PCS:
-
Petroleum ether fraction
- BCS:
-
n-Butanol fraction
- TPC:
-
Total phenolic content
- GC-MS:
-
Gas chromatography mass spectrometry
- PPAR:
-
Peroxisome proliferator-activated receptors
- NOAEL:
-
No-observed-adverse-effect-level
- AST:
-
Aspartate aminotransferase
- ALT:
-
Alanine transaminase
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PR planned and supervised the manuscript, JS conceptualized and developed the manuscript, SKur co-supervised, reviewed and illustrated the manuscript and VN co-supervised, interpreted the data and proof read the manuscript.
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Singh, J., Rasane, P., Nanda, V. et al. Bioactive compounds of corn silk and their role in management of glycaemic response. J Food Sci Technol 60, 1695–1710 (2023). https://doi.org/10.1007/s13197-022-05442-z
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DOI: https://doi.org/10.1007/s13197-022-05442-z