Abstract
For the management and prevention of many chronic and acute diseases, the rapid quantification of toxicity in food and feed products have become a significant concern. Technology advancements in the area of biosensors, bioelectronics, miniaturization techniques, and microfluidics have shown a significant impact than conventional methods which have given a boost to improve the sensing performance towards food analyte detection. In this article, recent literature of Aflatoxin B1 (AFB1), worldwide permissible limits, major outbreaks and severe impact on healthy life have been discussed. An improvement achieved in detection range, limit of detection, shelf-life of the biosensor by integrated dimensional nanomaterials such as zero-dimension, one-dimension and two-dimension for AFB1 detection using electrical and optical transduction mechanism has been summarized. A critical overview of the latest trends using paper-based and micro-spotted array integrated with the anisotropic shape of nanomaterials, portable microfluidic devices have also been described together with future perspectives for further advancements.
Similar content being viewed by others
Code availability
Not applicable.
References
Adeyeye SAO (2016) Fungal mycotoxins in foods: a review. Cogent Food Agric 2(1):1213127
Afsah-Hejri L, Jinap S, Hajeb P, Radu S, Shakibazadeh S (2013) A review on mycotoxins in food and feed: malaysia case study. Compr Rev Food Sci Food Saf 12(6):629–651
Althagafi II, Ahmed SA, El-Said WA (2019) Fabrication of gold/graphene nanostructures modified ITO electrode as highly sensitive electrochemical detection of Aflatoxin B1. PLoS ONE 14(1):e0210652
Aquino S, Corrêa B (2011) Aflatoxins in pet foods: a risk to special consumers. In: Aflatoxins-detection, measurements & control, pp 53–76
Ashraf MW, Tayyaba S, Afzulpurkar N (2011) Micro electromechanical systems (MEMS) based microfluidic devices for biomedical applications. Int J Mol Sci 12(6):3648–3704
Ben Abdallah Z, Grauby-Heywang C, Beven L, Cassagnere S, Moroté F, Maillard E, Sghaier H, Cohen Bouhacina T (2019) Development of an ultrasensitive label-free immunosensor for fungal aflatoxin B1 detection. Biochem Eng J 150:107262
Bhardwaj H, Singh C, Pandey MK, Sumana G (2016) Star shaped zinc sulphide quantum dots self-assembled monolayers: Preparation and applications in food toxin detection. Sens Actuators B Chem 231:624–633
Bhardwaj H, Singh C, Kotnala RK, Sumana G (2018) Graphene quantum dots-based nano-biointerface platform for food toxin detection. Anal Bioanal Chem 410:1–11
Bhardwaj H, Pandey M, Rajesh, & Sumana, G. (2019) Electrochemical Aflatoxin B1 immunosensor based on the use of graphene quantum dots and gold nanoparticles. Microchim Acta 186(8):592
Bhardwaj H, Marquette CA, Dutta P, Sumana G (2020a) Integrated graphene quantum dot decorated functionalized nanosheet biosensor for mycotoxin detection. Anal Bioanal Chem 412(25):7029–7041
Bhardwaj H, Sumana G, Marquette CA (2020b) A label-free ultrasensitive microfluidic surface Plasmon resonance biosensor for Aflatoxin B1 detection using nanoparticles integrated gold chip. Food Chem 307:125530
Bhardwaj H, Sumana G, Marquette CA (2020c) Gold nanobipyramids integrated ultrasensitive optical and electrochemical biosensor for Aflatoxin B1 detection. Talanta 222:121578
Bunney J, Williamson S, Atkin D, Jeanneret M, Cozzolino D, Chapman J (2017) The use of electrochemical biosensors in food analysis. Curr Res Nutr Food Sci J 5(3):183–195
Busa LS, Mohammadi S, Maeki M, Ishida A, Tani H, Tokeshi M (2016) A competitive immunoassay system for microfluidic paper-based analytical detection of small size molecules. The Analyst 141(24):6598–6603
Chen BH, Inbaraj BS (2016) 12: Nanomaterial-based sensors for mycotoxin analysis in food. Nov Approaches Nanotechnol Food 1:387–423
Chen L, Jiang J, Shen G, Yu R (2014) A label-free electrochemical impedance immunosensor for the sensitive detection of aflatoxin B1. Anal Methods 7:2354–2359
Chen Y, Meng X, Zhu Y, Shen M, Lu Y, Cheng J, Xu Y (2018) Rapid detection of four mycotoxins in corn using a microfluidics and microarray-based immunoassay system. Talanta 186:299–305
Costa M, Frías I, Andrade C, Oliveira MDL (2017) Impedimetric immunoassay for aflatoxin B1 using a cysteine modified gold electrode with covalently immobilized carbon nanotubes. Microchim Acta 184:1–9
Das Q, Islam MR, Marcone MF, Warriner K, Diarra MS (2017) Potential of berry extracts to control foodborne pathogens. Food Control 73:650–662
Doss J, Culbertson K, Hahn D, Camacho J, Barekzi N (2017) A review of phage therapy against bacterial pathogens of aquatic and terrestrial organisms. Viruses 9(3):50
Durán N, Marcato PD (2013) Nanobiotechnology perspectives. Role of nanotechnology in the food industry: a review. Int J Food Sci Technol 48(6):1127–1134
Hajslova J, Zachariasova M, Cajka T (2011) Analysis of multiple mycotoxins in food. Mass Spectrom Food Saf 747:233–258
Hu W, Chen H, Zhang H, He G, Li X, Zhang X, Liu Y, Li CM (2014) Sensitive detection of multiple mycotoxins by SPRi with gold nanoparticles as signal amplification tags. J Colloid Interface Sci 431:71–76
Hu H, Cao L, Li Q, Ma K, Yan P, Kirk DW (2015) Fabrication and modeling of an ultrasensitive label free impedimetric immunosensor for Aflatoxin B1 based on poly(o-phenylenediamine) modified gold 3D nano electrode ensembles. RSC Adv 5(68):55209–55217
Jaimez J, Fente CA, Vazquez BI, Franco CM, Cepeda A, Mahuzier G, Prognon P (2000) Application of the assay of aflatoxins by liquid chromatography with fluorescence detection in food analysis. J Chromatogr A 882(1):1–10
Joshi S, Segarra-Fas A, Peters J, Zuilhof H, van Beek TA, Nielen MWF (2016) Multiplex surface plasmon resonance biosensing and its transferability towards imaging nanoplasmonics for detection of mycotoxins in barley. Analyst 141(4):1307–1318
Kabak B, Dobson A (2015) Mycotoxins in spices and herbs: an update. Crit Rev Food Sci Nutr 57(1):18–34
Käferstein FK, Motarjemi Y, Bettcher DW (1997) Foodborne disease control: a transnational challenge. Emerg Infect Dis 3(4):503–510
Kasoju A, Shrikrishna NS, Shahdeo D, Khan AA, Alanazi AM, Gandhi S (2020) Microfluidic paper device for rapid detection of aflatoxin B1 using an aptamer based colorimetric assay. RSC Adv 10(20):11843–11850
Khlangwiset P, Shephard GS, Wu F (2011) Aflatoxins and growth impairment: a review. Crit Rev Toxicol 41(9):740–755
Kolosova AY (2006) Direct competitive ELISA based on a monoclonal antibody for detection of aflatoxin B1. Stabilization of ELISA kit components and application to grain samples. Anal Bioanal Chem 384(1):286–294
Lee T-H, Hirst DJ, Kulkarni K, Del Borgo MP, Aguilar M-I (2018) Exploring molecular-biomembrane interactions with surface plasmon resonance and dual polarization interferometry technology: expanding the spotlight onto biomembrane structure. Chem Rev 118(11):5392–5487
Li Q, Lv S, Lu M, Lin Z, Tang D (2016a) Potentiometric competitive immunoassay for determination of aflatoxin B1 in food by using antibody-labeled gold nanoparticles. Microchim Acta 183:1–8
Li Z, Ye Z, Fu Y, Xiong Y, Li Y (2016b) A portable electrochemical immunosensor for rapid detection of trace aflatoxin B1 in rice. Anal Methods 8(3):548–553
Li Z, Li X, Jian M, Geleta GS, Wang Z (2020) Two-dimensional layered nanomaterial-based electrochemical biosensors for detecting microbial toxins. Toxins 12(1):20
Linting Z, Ruiyi L, Zaijun L, Qianfang X, Yinjun F, Junkang L (2012) An immunosensor for ultrasensitive detection of aflatoxin B1 with an enhanced electrochemical performance based on graphene/conducting polymer/gold nanoparticles/the ionic liquid composite film on modified gold electrode with electrodeposition. Sens Actuators B Chem 174:359–365
Liu Q, Liu Y, Chen S, Wang F, Peng W (2017) A low-cost and portable dual-channel fiber optic surface plasmon resonance system. Sensors 17(12):2797
Lu Z, Chen X, Wang Y, Zheng X, Li C (2015) Aptamer based fluorescence recovery assay for aflatoxin B1 using a quencher system composed of quantum dots and graphene oxide. Microchim Acta 182:571–578
Luo Y, Liu X, Li J (2018) Updating techniques on controlling mycotoxins: a review. Food Control 89:123–132
Ma H, Sun J, Zhang Y, Bian C, Xia S, Zhen T (2016a) Label-free immunosensor based on one-step electrodeposition of chitosan-gold nanoparticles biocompatible film on Au microelectrode for determination of aflatoxin B1 in maize. Biosens Bioelectron 80:222–229
Ma H, Sun J, Zhang Y, Xia S (2016b) Disposable amperometric immunosensor for simple and sensitive determination of aflatoxin B1 in wheat. Biochem Eng J 115:38–46
Majzik A, Hornok V, Sebok D, Bartók T, Szente L, Tuza K, Dekany I (2015) Sensitive detection of aflatoxin B1 molecules on gold spr chip surface using functionalized gold nanoparticles. Cereal Res Commun 43:426–437
Malhotra B, Srivastava S, Ali MA, Singh C (2014) Nanomaterial-based biosensors for food toxin detection. Appl Biochem Biotechnol 174:880–896
Malhotra B, Srivastava S, Augustine S (2015) Biosensors for food toxin detection: carbon nanotubes and graphene. MRS Online Proc Libr 1725(1):24–34
Migliorini FL, Santos DMD, Soares AC, Mattoso LH, Oliveira ON, Correa DS (2020) Design of a low-cost and disposable paper-based immunosensor for the rapid and sensitive detection of aflatoxin B1. Chemosensors 8(3):87
Miklós G, Angeli C, Ambrus Á, Nagy A, Kardos V, Zentai A, Kerekes K, Farkas Z, Jóźwiak Á, Bartók T (2020) Detection of aflatoxins in different matrices and food-chain positions. Front Microbiol 11:1916
Mithöfer A, Maffei M (2016) General mechanisms of plant defense and plant toxins. Plant Toxins, pp 1–22
Mondal K, Ali MA, Srivastava S, Malhotra BD, Sharma A (2016) Electrospun functional micro/nanochannels embedded in porous carbon electrodes for microfluidic biosensing. Sens Actuators B Chem 229:82–91
Moon J, Byun J, Kim H, Lim E-K, Jeong J, Jung J, Kang T (2018) On-site detection of aflatoxin B1 in grains by a palm-sized surface plasmon resonance sensor. Sensors 18:598
Nasirian V, Chabok A, Barati A, Rafienia M, Arabi MS, Shamsipur M (2017) Ultrasensitive aflatoxin B1 assay based on FRET from aptamer labelled fluorescent polymer dots to silver nanoparticles labeled with complementary DNA. Microchim Acta 184(12):4655–4662
Neethirajan S, Ragavan KV, Weng X (2018) Agro-defense: biosensors for food from healthy crops and animals. Trends Food Sci Technol 73:25–44
Nishimwe K, Wanjuki I, Karangwa C, Darnell R, Harvey J (2017) An initial characterization of aflatoxin B1 contamination of maize sold in the principal retail markets of Kigali, Rwanda. Food Control 73:574–580
Oranusi S, Nwankwo U, Onu-Okpara I, Olopade B (2017) Assessment of micro flora, deoxynivalenol (Don) and fumonisin contamination of grains sold in local markets, Nigeria. Conv J Phys Life Sci 4(2):42–49
Ozakyol A (2017) Global epidemiology of hepatocellular carcinoma (HCC epidemiology). J Gastrointest Cancer 48(3):238–240
Park JH, Kim Y-P, Kim I-H, Ko S (2014) Rapid detection of aflatoxin B1 by a bifunctional protein crosslinker-based surface plasmon resonance biosensor. Food Control 36(1):183–190
Rai M, Jogee PS, Ingle AP (2015) Emerging nanotechnology for detection of mycotoxins in food and feed. Int J Food Sci Nutr 66(4):363–370
Rasmussen S, Andersen A, Andersen N, Nielsen K, Hansen P, Larsen TO (2016) Chemical diversity, origin, and analysis of phycotoxins. J Nat Prod 79:662–673
Reddy B, Raghavender C (2007) Outbreaks of aflatoxicoses in India. Afr J Food Agric Nutr Dev 7(5):1–15
Reddy KRN, Salleh B, Saad B, Abbas H, Abel C, Shier WT (2010) An overview of mycotoxin contamination in foods and its implications for human health. Toxin Rev 29:3–26
Sabet F, Khabbaz H, Hosseini M, Dadmehr M, Ganjali M (2016) FRET-based aptamer biosensor for selective and sensitive detection of aflatoxin B1 in peanut and rice. Food Chem 220:527–532
Sadeghi H (2016) Graphene-based DNA sensors. In: Graphene science handbook: applications and industrialization, vol 13. CRC Press, pp 13–26
Scott PM (1978) Mycotoxins in feeds and ingredients and their origin. J Food Prot 41(5):385–398
Seale AC, Blencowe H, Manu AA, Nair H, Bahl R, Qazi SA, Zaidi AK, Berkley JA, Cousens SN, Lawn JE (2014) Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, south Asia, and Latin America for 2012: a systematic review and meta-analysis. Lancet Infect Dis 14(8):731–741
Sharma A, Kumar A, Khan R (2017) Electrochemical immunosensor based on poly (3,4-ethylenedioxythiophene) modified with gold nanoparticle to detect aflatoxin B1. Mater Sci Eng C 76:802–809
Sharma A, Khan R, Catanante G, Sherazi TA, Bhand S, Hayat A, Marty JL (2018) Designed strategies for fluorescence-based biosensors for the detetion of mycotoxins. Toxins 10(5):197
Shekhar M, Singh N, Sunaina SV, Kumar A. (2018) Effects of climate change on occurrence of aflatoxin and its impacts on maize in India. Int J Curr Microbiol Appl Sci 7(6):109–116
Shipway AN, Katz E, Willner I (2000) Nanoparticle arrays on surfaces for electronic, optical, and sensor applications. ChemPhysChem 1(1):18–52
Singh J, Mehta A (2020) Rapid and sensitive detection of mycotoxins by advanced and emerging analytical methods: a review. Food Sci Nutr 8(5):2183–2204
Singh C, Srivastava S, Ali MA, Gupta DT, Sumana G, Srivastava A, Mathur RB, Malhotra B (2013) Carboxylated multiwalled carbon nanotube based biosensor for aflatoxin detection. Sens Actuators B Chem 185:258–264
Solanki P, Singh J, Rupavali B, Tiwari S, Malhotra B (2016) Bismuth oxide nanorods based immunosensor for mycotoxin detection. Mater Sci Eng C 70:564–571
Sozer N, Kokini JL (2009) Nanotechnology and its applications in the food sector. Trends Biotechnol 27(2):82–89
Srivastava S, Kumar V, Ali MA, Solanki P, Srivastava A, Sumana G, Saxena P, Joshi DA, Malhotra B (2013) Electrophoretically deposited reduced graphene oxide platform for food toxin detection. Nanoscale 5(7):3043–3051
Srivastava S, Ali MA, Umrao S, Parasar U, Srivastava A, Sumana G, Malhotra B, Pandey S, Hayase S (2014) Graphene oxide-based biosensor for food toxin detection. Appl Biochem Biotechnol 174(3):960–970
Srivastava S, Abraham S, Singh C, Ali MA, Srivastava A, Sumana G, Malhotra B (2015) Protein conjugated carboxylated gold@reduced graphene oxide for aflatoxin B 1 detection. RSC Adv 5:5406–5414
Stepurska K, Soldatkin O, Arkhypova V, Soldatkin A, Lagarde F, Jaffrezic-Renault N, Dzyadevych S (2015) Development of novel enzyme potentiometric biosensor based on pH-sensitive field-effect transistors for aflatoxin B1 analysis in real samples. Talanta 144:1079–1084
Szabo A, Stolz L, Granzow R (1995) Surface plasmon resonance and its use in biomolecular interaction analysis (BIA). Curr Opin Struct Biol 5(5):699–705
Tan G-R, Wang M, Hsu C-Y, Chen N, Zhang Y (2016) Small upconverting fluorescent nanoparticles for biosensing and bioimaging. Adv Opt Mater 4(7):984–997
Tefera T, Kanampiu F, De Groote H, Hellin J, Mugo S, Kimenju S, Beyene Y, Boddupalli P, Shiferaw B, Banziger M (2011) The metal silo: an effective grain storage technology for reducing post-harvest insect and pathogen losses in maize while improving smallholder farmers’ food security in developing countries. Crop Prot 30:240–245
Torres A, Barros G, Palacios S, Chulze S, Battilani P (2014) Review on pre- and post-harvest management of peanuts to minimize aflatoxin contamination. Food Res Int 62:11–19
Wacoo AP, Ocheng M, Wendiro D, Hawumba JF (2016) Development and characterization of an electroless plated silver/cysteine sensor platform for the electrochemical determination of aflatoxin B1. J Sens 2016:1–8
Wang Z, Li J, Xu L, Feng Y (2014) Electrochemical sensor for determination of aflatoxin B1 based on multiwalled carbon nanotubes-supported Au/Pt bimetallic nanoparticles. J Solid State Electrochem 18:2487–2496
Wei T, Ren P, Huang L, Ouyang Z, Wang Z, Kong X, Li T, Yin Y, Wu Y, He Q (2019) Simultaneous detection of aflatoxin B1, ochratoxin A, zearalenone and deoxynivalenol in corn and wheat using surface plasmon resonance. Food Chem 300:125176
Xie H, Dong J, Duan J, Hou J, Ai S, Li X (2018) Magnetic nanoparticles-based immunoassay for aflatoxin B1 using porous g-C3N4 nanosheets as fluorescence probes. Sens Actuators B Chem 278:147–152
Yan C, Wang Q, Yang Q, Wu W (2020) Recent advances in aflatoxins detection based on nanomaterials. Nanomaterials 10(9):1626
Zekavati R, Safi S, Hashemi J, Rahmani-Cherati T, Tabatabaei M, Mohsenifar A, Bayat M (2013) Highly sensitive FRET-based fluorescence immunoassay for aflatoxin B1 using cadmium telluride quantum dots. Microchim Acta 180:1217–1223
Zhang Y, Bai Y, Yan B (2010) Functionalized carbon nanotubes for potential medicinal applications. Drug Discov Today 15:428–435
Zhang S, Shen Y, Shen G, Wang S, Shen G, Yu R (2015) Electrochemical immunosensor based on Pd-Au nanoparticles supported on functionalized PDDA-MWCNT nanocomposites for aflatoxin B1 detection. Anal Biochem 494:10–15
Zhang X, Li C-R, Wang W-C, Xue J, Huang Y-L, Yang X-X, Tan B, Zhou X-P, Shao C, Ding S-J, Qiu J-F (2016) A novel electrochemical immunosensor for highly sensitive detection of aflatoxin B1 in corn using single-walled carbon nanotubes/chitosan. Food Chem 192:197–202
Zinedine A, Mañes J (2009) Occurrence and legislation of mycotoxins in food and feed from Morocco. Food Control 20:334–344
Acknowledgements
We are thankful to Director, CSIR-National Physical Laboratory, New Delhi, India, for providing the facilities. H.B. is grateful to CEFIPRA for the award of Raman-Charpak Fellowship-2017.
Funding
No funding was received to complete the review.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
There are no conflicts of interest to declare.
Ethics approval
Copyright permission is taken for reproduction of the figures (Figs. 5, 6, 7, 8) in this review article.
Consent to participate
Informed consent was obtained from all individual participants included in the review.
Consent for publication
Presented work has not been published or under consideration in any other journal and copy right permission is taken to reprint individual’s image.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Bhardwaj, H., Rajesh & Sumana, G. Recent advances in nanomaterials integrated immunosensors for food toxin detection. J Food Sci Technol 59, 12–33 (2022). https://doi.org/10.1007/s13197-021-04999-5
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13197-021-04999-5