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Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

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Abstract

Hypertension, hyperlipidemia, and diabetes are important precursors of cardiovascular disease. Here, we evaluated the antihypertensive, antihyperlipidemic, and antidiabetic potential of five types of sprouts in fructose-loaded spontaneously hypertensive rats (SHRs). Powdered sprouts (PSs) were produced from mung bean, broccoli, radish, and buckwheat sprouts and germinated soybeans by lyophilization. The PSs were analyzed for nutritional composition and bioactive agents (γ-aminobutyric acid [GABA], coenzyme Q10 [CoQ10], rutin, and myo-inositol-1,2,3,4,5,6-hexakisphosphate [IP6]) and functionally tested in SHRs given water containing 25 % fructose and diets containing 30 % PS for 46 days. All PSs were nutritionally rich in protein and dietary fiber. CoQ10, GABA/rutin, and GABA/IP6 were abundant in broccoli, buckwheat, and germinated soybean PSs, respectively. Mung bean, broccoli, and buckwheat PSs caused significant reductions in heart rates and/or serum triglycerides. Mung bean PS also significantly reduced serum total cholesterol. These data supported the antihypertensive and antihyperlipidemic potential of mung bean, broccoli, and buckwheat sprouts.

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Acknowledgments

We greatly appreciate the financial support provided by the “subsidy for a project contributing to food production technology” of the Ministry of Agriculture, Forestry and Fisheries of Japan.

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Authors and Affiliations

  1. Institute of Agriculture, Academic Assembly, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598, Japan

    Kozo Nakamura

  2. Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598, Japan

    Kozo Nakamura & Masahiro Koyama

  3. Department of Bioscience and Biotechnology, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598, Japan

    Kozo Nakamura & Ryuya Ishida

  4. Saladcosmo Co., Ltd, 1-15 Sentanbayashi, Nakatsugawa, Gifu, 509-9131, Japan

    Takashi Kitahara

  5. Department of Metabolic Regulation, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Takero Nakajima & Toshifumi Aoyama

Authors
  1. Kozo Nakamura
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  2. Masahiro Koyama
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  3. Ryuya Ishida
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  4. Takashi Kitahara
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  5. Takero Nakajima
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  6. Toshifumi Aoyama
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Corresponding author

Correspondence to Kozo Nakamura.

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Highlights

• Powdered sprouts (PSs) were prepared from five kinds of marketed sprouts.

• All PSs were nutritionally rich in dietary fiber and contained functional ingredients.

• Food functionalities of PSs were tested in spontaneously hypertensive rats given fructose.

• Mung bean, broccoli and buckwheat PSs significantly reduced serum triglycerides.

• Mung bean PS also significantly reduced serum total cholesterol.

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Nakamura, K., Koyama, M., Ishida, R. et al. Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs. J Food Sci Technol 53, 581–590 (2016). https://doi.org/10.1007/s13197-015-2048-0

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  • DOI: https://doi.org/10.1007/s13197-015-2048-0

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