EPMA Journal

, Volume 8, Issue 2, pp 119–127

Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon?

  • Jiri PolivkaJr
  • Milena Kralickova
  • Jiri Polivka
  • Christina Kaiser
  • Walther Kuhn
  • Olga Golubnitschaja
Review

DOI: 10.1007/s13167-017-0087-5

Cite this article as:
Polivka, J., Kralickova, M., Polivka, J. et al. EPMA Journal (2017) 8: 119. doi:10.1007/s13167-017-0087-5

Abstract

The breast cancer (BC) diagnosis currently experiences the epidemic evolution with more than half of million deaths each year. Despite screening programmes applied and treatments available, breast cancer patients frequently develop distant metastases. The brain is one of the predominant sites of the metastatic spread recorded for more than 20% of BC patients, in contrast to the general population, where brain tumours are rarely diagnosed. Although highly clinically relevant, the brain tumour mystery in the cohort of breast cancer patients has not been yet adequately explained. This review summarises currently available information on the risk factors predicting brain metastases in BC patients to motivate the relevant scientific areas to explore the data/facts available and elucidate disease-specific mechanisms that are of a great clinical utility.

Keywords

Breast cancer Brain metastasis Risk factors Multilevel diagnostics Patient stratification Predictive preventive and personalised medicine 

Copyright information

© European Association for Predictive, Preventive and Personalised Medicine (EPMA) 2017

Authors and Affiliations

  • Jiri PolivkaJr
    • 1
    • 2
  • Milena Kralickova
    • 1
    • 2
  • Jiri Polivka
    • 3
  • Christina Kaiser
    • 4
    • 5
    • 6
  • Walther Kuhn
    • 4
    • 5
    • 6
  • Olga Golubnitschaja
    • 5
    • 6
    • 7
  1. 1.Department of Histology and Embryology, Faculty of Medicine in PlzenCharles UniversityPlzenCzech Republic
  2. 2.Biomedical Centre, Faculty of Medicine in PlzenCharles UniversityPlzenCzech Republic
  3. 3.Department of NeurologyFaculty Hospital PlzenPlzenCzech Republic
  4. 4.Department of Gynaecology, Medical FacultyFriedrich-Wilhelms-University of BonnBonnGermany
  5. 5.Breast Cancer Research CentreFriedrich-Wilhelms-University of BonnBonnGermany
  6. 6.Centre for Integrated Oncology Cologne-BonnFriedrich-Wilhelms-University of BonnBonnGermany
  7. 7.Department of RadiologyFriedrich-Wilhelms-University of BonnBonnGermany

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