Skip to main content
SpringerLink
Log in

Interleukin-6 is a better metabolic biomarker than interleukin-18 in young healthy adults

  • Original Paper
  • Published:
Journal of Physiology and Biochemistry Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Ahmad R, Al-Mass A, Al-Ghawas D et al (2013) Interaction of osteopontin with IL-18 in obese individuals: implications for insulin resistance. PLoS ONE 8(5):e63944

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Blackburn P, Després J-P, Lamarche B et al (2006) Postprandial variations of plasma inflammatory markers in abdominally obese men. Obesity 14(10):1747–1754

    Article  CAS  PubMed  Google Scholar 

  3. Blankenberg S, Luc G, Ducimetière P et al (2003) Interleukin-18 and the risk of coronary heart disease in European men: the prospective epidemiological study of myocardial infarction (PRIME). Circulation 108(20):2453–2459

    Article  CAS  PubMed  Google Scholar 

  4. Bondia-Pons I, Ryan L, Martinez JA (2012) Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem 68(4):701–711

    Article  CAS  PubMed  Google Scholar 

  5. Breyer MK, Rutten EPA, Vernooy JHJ, Spruit MA, Dentener MA, van der Kallen C, vanGreevenbroek MMJ, Wouters EFM (2011) Gender differences in the adipose secretome system in chronic obstructive pulmonary disease (COPD): a pivotal role of leptin. Respir Med 105:1046–1053

    Article  PubMed  Google Scholar 

  6. Bruun J, Stallknecht B, Helge J, Richelsen B (2007) Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss. Eur J Endocrinol 157:465–471

    Article  CAS  PubMed  Google Scholar 

  7. Chen YC, Chen SD, Miao L, Liu ZG, Li W, Zhao ZX, Sun XJ, Jiang GX, Cheng Q (2012) Serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with multiple sclerosis. J Neuroimmunol 243(1–2):56–60

    Article  CAS  PubMed  Google Scholar 

  8. Ching PL, Willett WC, Rimm EB et al (1996) Activity level and risk of overweight in male health professionals. Am J Public Health 86(1):25–30

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Diehl S, Rincón M (2002) The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 39(9):531–536

    Article  CAS  PubMed  Google Scholar 

  10. Dinarello CA (1999) IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol 103(1):11–24

    Article  CAS  PubMed  Google Scholar 

  11. Fantuzzi G (2005) Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115(5):911–919

    Article  CAS  PubMed  Google Scholar 

  12. Gerdes N, Sukhova GK, Libby P et al (2002) Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. J Exp Med 195:245–257

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Goyenechea E, Parra D, Martínez JA (2007) Impact of interleukin 6–174G > C polymorphism on obesity-related metabolic disorders in people with excess in body weight. Metabolism 56(12):1643–1648

    Article  CAS  PubMed  Google Scholar 

  14. Gülçubuk A, Haktanir D, Cakiris A et al (2014) The effects of resveratrol on tissue injury, oxidative damage, and pro-inflammatory cytokines in an experimental model of acute pancreatitis. J Physiol Biochem 70(2):397–406

    Article  PubMed  Google Scholar 

  15. Gustafson B, Hammarstedt A, Andersson CX et al (2007) Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol 27(11):2276–2283

    Article  CAS  PubMed  Google Scholar 

  16. Helmersson J, Larsson A, Vessby B, Basu S (2005) Active smoking and a history of smoking are associated with enhanced prostaglandin F2α, interleukin-6 and F2-isoprostane formation in elderly men. Atherosclerosis 181(1):201–207

    Article  CAS  PubMed  Google Scholar 

  17. Hermsdorff H, Zulet MA, Abete I, Martínez JA (2011) A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects. Eur J Nutr 50(1):61–69

    Article  CAS  PubMed  Google Scholar 

  18. Hermsdorff H, Zulet MA, Puchau B, Martínez JA (2011) Central adiposity rather than total adiposity measurements are specifically involved in the inflammatory status from healthy young adults. Inflammation 34(3):161–170

    Article  CAS  PubMed  Google Scholar 

  19. Hermsdorff HH, Zulet MA, Martínez JA (2011) The implication of unknown bioactive compounds and cooking techniques in relations between the variety in fruit and vegetable intake and inflammation. Am J Clin Nutr 93(6):1384

    Article  CAS  PubMed  Google Scholar 

  20. Hermsdorff HHM, Puchau B, Bressan J, Martínez JA (2009) Association of retinol-binding protein-4 with dietary selenium intake and other lifestyle features in young healthy women. Nutrition 25(4):392–399

    Article  CAS  PubMed  Google Scholar 

  21. Hermsdorff HHM, Puchau B, Bressan J, Martínez JA (2010) Association of body Fat distribution with proinflammatory gene expression in peripheral blood mononuclear cells from young adult subjects. OMICS: J Integr Biol 14(3):297–307

    Article  CAS  Google Scholar 

  22. Hung J, McQuillan BM, Chapman CML (2005) Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance. Arterioscler Thromb Vasc Biol 25(6):1268–1273

    Article  CAS  PubMed  Google Scholar 

  23. Kim T, Choi S, Ha E et al (2013) IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle. Acta Diabetol 50(2):189–200

    Article  CAS  PubMed  Google Scholar 

  24. Lavie CJ, Church TS, Milani RV, Earnest CP (2011) Impact of physical activity, cardiorespiratory fitness, and exercise training on markers of inflammation. J Cardiopulm Rehabil Prev 31(3):137–145

    Article  PubMed  Google Scholar 

  25. Matthews DR, Hosker JP, Rudenski AS, Nayloret BA et al (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412–9

    Article  CAS  PubMed  Google Scholar 

  26. McCarty MF (1999) Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: down-regulation with essential fatty acids, athanol and pentoxifylline. Med Hypotheses 52(5):465–477

    Article  CAS  PubMed  Google Scholar 

  27. Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454(7203):428–435

    Article  CAS  PubMed  Google Scholar 

  28. Moreno-Aliaga M, Campión J, Milagro FI et al (2005) Adiposity and proinflammatory state: the chicken or the egg. Adipocytes 1:1–16

    Google Scholar 

  29. Netea MG, Joosten LAB, Lewis E et al (2006) Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med 12(6):650–656

    Article  CAS  PubMed  Google Scholar 

  30. Opstad TB, Pettersen AA, Arnesen H, Seljeflot I (2011) Circulating levels of IL-18 are significantly influenced by the IL-18 + 183 A/g polymorphism in coronary artery disease patients with diabetes type 2 and the metabolic syndrome: an observational study. Cardiovasc Diabetol 10:110

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  31. Pannacciulli N, Cantatore FP, Minenna A et al (2001) C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women. International journal of obesity and related metabolic disorders. Int J Obes Relat Metab Disord 25(10):1416–1420

    Article  CAS  PubMed  Google Scholar 

  32. Pedersen M, Bruunsgaard H, Weis N et al (2003) Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mech Ageing Dev 124(4):495–502

    Article  CAS  PubMed  Google Scholar 

  33. Petersen AMW, Pedersen BK (2006) The role of il-6 in mediating the anti-inflammatory effects of exercise. J Physiol Pharmacol 57(10):43–51

    PubMed  Google Scholar 

  34. Quintero P, Milagro FI, Campion J, Martínez JA (2010) Impact of oxygen availability on body weight management. Med Hypotheses 74(5):901–907

    Article  CAS  PubMed  Google Scholar 

  35. Ropelle ER, Flores MB, Cintra DE et al (2010) IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKβ and ER stress inhibition. PLoS Biol 8(8):e1000465

    Article  PubMed Central  PubMed  Google Scholar 

  36. Safavi SM, Ziaei R, Marac MR (2012) Association of serum ceruloplasmin level with obesity: some components of metabolic syndrome and high-sensitive C-reactive protein in Iran. J Obes 2012:951093

    Article  PubMed Central  PubMed  Google Scholar 

  37. Simental-Mendía L, Rodríguez-Morán M, Guerrero-Romero F (2008) The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord 6:299–304

    Article  PubMed  Google Scholar 

  38. Thaler JP, Schwartz MW (2010) Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 151(9):4109–4115

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  39. Vachharajani V, Granger DN (2009) Adipose tissue: a motor for the inflammation associated with obesity. IUBMB Life 61(4):424–430

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  40. Vasques ACJ, Novaes FS, de Oliveira MS et al (2011) TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study. Diabetes Res Clin Pract 93(3):e98–e100

    Article  CAS  PubMed  Google Scholar 

  41. Wang B, Li Q, Jiang Y et al (2011) Serum complement C3 has a stronger association with insulin resistance than high sensitive C-reactive protein in non-diabetic Chinese. Inflamm Res 60(1):63–68

    Article  CAS  PubMed  Google Scholar 

  42. Whitworth JA, Chalmers J (2004) World health organisation-international society of hypertension (WHO/ISH) hypertension guidelines. Clin Exp Hypertens 26(7–8):747–52

    Article  PubMed  Google Scholar 

  43. Yudkin JS, Stehouwer CDA, Emeis JJ, Coppack SW (1999) C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19(4):972–978

    Article  CAS  PubMed  Google Scholar 

  44. Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V (2000) Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148(2):209–214

    Article  CAS  PubMed  Google Scholar 

  45. Zilverschoon GRC, Tack CJ, Joosten LAB et al (2008) Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus. Int J Obes 32(9):1407–1414

    Article  CAS  Google Scholar 

  46. Zorrilla EP, Sanchez-Alavez M, Sugama S et al (2007) Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc Natl Acad Sci U S A 104(26):11097–11102

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  47. Zulet MA, Puchau B, Navarro C et al (2007) Biomarcadores del estado inflamatorio: nexo de unión con la obesidad y complicaciones asociadas. Nutr Hosp 22(5):511–527

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We wish to thank the physician Blanca E. Martínez de Morentín, the nurse Salomé Pérez, and the technician Verónica Ciaurriz. This work was supported by Línea Especial about Nutrition, Obesity and Health (University of Navarra LE/97) and CIBERobn. We also thanks to Capes for a PhD scholarship awarded to JCC Carraro. J Bressan and HHM Hermsdorff are CNPq and FUNARBE-UFV fellows, respectively.

Conflict of interest

The authors declare that they have no competing interests.

Author contributions

JCCC analyzed and wrote the manuscript. HHMH contributed in the design, field work, data collection, and analysis. BP contributed in the design, field work, and data collection. MAZ, FIM, and JB contributed in the design and analysis. JAM contributed in the general coordination, design, and financial management. All authors assisted in editing the manuscript as well as reading and approving the final manuscript.

Author information

Authors and Affiliations

  1. Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil

    Júlia Cristina Cardoso Carraro, Helen Hermana M. Hermsdorff & Josefina Bressan

  2. Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, C/ Irunlarrea 1, 31008, Pamplona, Navarra, Spain

    Blanca Puchau, M. Ángeles Zulet, Fermín I. Milagro & J. Alfredo Martínez

  3. CIBERobn, Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y la Nutrición, Carlos III Institute of Health, Madrid, Spain

    M. Ángeles Zulet, Fermín I. Milagro & J. Alfredo Martínez

Authors
  1. Júlia Cristina Cardoso Carraro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Helen Hermana M. Hermsdorff
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Blanca Puchau
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Ángeles Zulet
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Fermín I. Milagro
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Josefina Bressan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. Alfredo Martínez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. Alfredo Martínez.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Carraro, J.C.C., Hermsdorff, H.H.M., Puchau, B. et al. Interleukin-6 is a better metabolic biomarker than interleukin-18 in young healthy adults. J Physiol Biochem 71, 527–535 (2015). https://doi.org/10.1007/s13105-015-0391-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13105-015-0391-2

Keywords

Search

Navigation