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Serum complement C3 has a stronger association with insulin resistance than high sensitive C-reactive protein in non-diabetic Chinese

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Abstract

Objective

To compare association of complement C3 (C3) and high sensitive C-reactive protein (hs-CRP) with insulin resistance.

Subjects

A total of 587 non-diabetic Chinese aged 20–80 years were recruited.

Methods

Complement C3 and hs-CRP were measured by the rate nephelometry method and the particle enhanced immunoturbidimetric method, respectively, and their relationship to insulin resistance was assessed. Insulin resistance was defined as the upper quartile of HOMA2-IR.

Results

Complement C3 and hs-CRP were significantly higher in subjects with insulin resistance than those without. Complement C3 was the second strongest determinant of insulin in the study (β = 0.34, P < 0.001). By regression analysis, C3 was significantly associated with insulin resistance (OR = 3.78, P < 0.05), independent of waist circumference and other metabolic risk factors; however, hs-CRP was not. Receiver operating characteristic curve analysis indicated the best model predicting insulin resistance was one that included C3 and waist circumference (AUC = 0.741, P < 0.05).

Conclusion

Compared to hs-CRP, serum C3 might be a better inflammatory marker of insulin resistance in the non-diabetic Chinese population.

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Acknowledgments

The present study was completed successfully with the help of the Medical Examination Center of The First Affiliated Hospital of Chongqing Medical University and the Laboratory Department of The First Affiliated Hospital of Chongqing Medical University. This research was supported by grants from the National Natural Science Foundation of China (No.30570876 and No.30700271).

Conflict of interest

The authors declare that there is no conflict of interest associated with this manuscript.

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Authors and Affiliations

  1. Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, Chongqing, 400016, China

    Bangqiong Wang, Qifu Li, Yuanjuan Jiang, Zhoujun Liu, Li Zhong, Qingfeng Cheng & Hua Qing

  2. Medical Examination Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

    Rong Luo

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  1. Bangqiong Wang
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  2. Qifu Li
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  3. Yuanjuan Jiang
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  7. Qingfeng Cheng
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Correspondence to Qifu Li.

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Responsible Editor: Ian Ahnfelt-Rønne.

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Wang, B., Li, Q., Jiang, Y. et al. Serum complement C3 has a stronger association with insulin resistance than high sensitive C-reactive protein in non-diabetic Chinese. Inflamm. Res. 60, 63–68 (2011). https://doi.org/10.1007/s00011-010-0236-y

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  • DOI: https://doi.org/10.1007/s00011-010-0236-y

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