Translational Stroke Research

, Volume 9, Issue 4, pp 356–374 | Cite as

Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell

  • Deepaneeta Sarmah
  • Harpreet Kaur
  • Jackson Saraf
  • Kanta Pravalika
  • Avirag Goswami
  • Kiran Kalia
  • Anupom Borah
  • Xin Wang
  • Kunjan R. Dave
  • Dileep R. Yavagal
  • Pallab BhattacharyaEmail author
Review Article


Stem cell therapy for ischemic stroke has widely been explored. Results from both preclinical and clinical studies have immensely supported the judicious use of stem cells as therapy. These provide an attractive means for preserving and replacing the damaged brain tissues following an ischemic attack. Since the past few years, researchers have used various types of stem cells to replenish insulted neuronal and glial cells in neurological disorders. In the present review, we discuss different types of stem cells employed for the treatment of ischemic stroke and mechanisms and challenges these cells face once introduced into the living system. Further, we also present different ways to maneuver and overcome challenges to translate the advances made at the preclinical level to clinics.


Ischemic stroke Stem cells Neuroprotection Cell engineering Preclinical Clinical 



The authors acknowledge the Department of Science and Technology (DST), Govt. of India, for their financial support through grant (SB/YS/LS-196/2014), International Society for Neurochemistry (ISN) Return Home grant, Department of Pharmaceuticals, Ministry of Chemical and Fertilizers, Govt of India and National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, India. The authors also want to express their thanks to Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA and the Director, NIPER Ahmedabad, for providing necessary support.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

The article does not contain any studies with animal or human subjects


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Deepaneeta Sarmah
    • 1
  • Harpreet Kaur
    • 1
  • Jackson Saraf
    • 1
  • Kanta Pravalika
    • 1
  • Avirag Goswami
    • 2
  • Kiran Kalia
    • 1
  • Anupom Borah
    • 3
  • Xin Wang
    • 4
  • Kunjan R. Dave
    • 2
  • Dileep R. Yavagal
    • 2
  • Pallab Bhattacharya
    • 1
    • 5
    Email author
  1. 1.Department of Pharmacology and ToxicologyNational Institute of Pharmaceutical Education and Research (NIPER) AhmedabadGandhinagarIndia
  2. 2.Department of NeurologyUniversity of Miami Miller School of MedicineMiamiUSA
  3. 3.Cellular and Molecular Neurobiology Laboratory, Department of Life Science and BioinformaticsAssam UniversitySilcharIndia
  4. 4.Department of NeurosurgeryBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  5. 5.Department of NeurosurgeryBoston Children’s Hospital, Harvard Medical SchoolBostonUSA

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