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Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell

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Abstract

Stem cell therapy for ischemic stroke has widely been explored. Results from both preclinical and clinical studies have immensely supported the judicious use of stem cells as therapy. These provide an attractive means for preserving and replacing the damaged brain tissues following an ischemic attack. Since the past few years, researchers have used various types of stem cells to replenish insulted neuronal and glial cells in neurological disorders. In the present review, we discuss different types of stem cells employed for the treatment of ischemic stroke and mechanisms and challenges these cells face once introduced into the living system. Further, we also present different ways to maneuver and overcome challenges to translate the advances made at the preclinical level to clinics.

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Acknowledgements

The authors acknowledge the Department of Science and Technology (DST), Govt. of India, for their financial support through grant (SB/YS/LS-196/2014), International Society for Neurochemistry (ISN) Return Home grant, Department of Pharmaceuticals, Ministry of Chemical and Fertilizers, Govt of India and National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, India. The authors also want to express their thanks to Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA and the Director, NIPER Ahmedabad, for providing necessary support.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, Gujarat, 382355, India

    Deepaneeta Sarmah, Harpreet Kaur, Jackson Saraf, Kanta Pravalika, Kiran Kalia & Pallab Bhattacharya

  2. Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA

    Avirag Goswami, Kunjan R. Dave & Dileep R. Yavagal

  3. Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, Assam, India

    Anupom Borah

  4. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Xin Wang

  5. Department of Neurosurgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Pallab Bhattacharya

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  1. Deepaneeta Sarmah
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  2. Harpreet Kaur
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  8. Xin Wang
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  10. Dileep R. Yavagal
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Correspondence to Pallab Bhattacharya.

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Sarmah, D., Kaur, H., Saraf, J. et al. Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell. Transl. Stroke Res. 9, 356–374 (2018). https://doi.org/10.1007/s12975-017-0580-0

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  • DOI: https://doi.org/10.1007/s12975-017-0580-0

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