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Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization

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Abstract

Background

A spontaneous mobilization of Peripheral Blood-Mononuclear CD34+ Cells (PB-MNC-CD34+) has recently been reported in human myocardial infarction and found to be related to improved heart function and survival. However, nothing is known regarding a possible relation between PB-MNC-CD34+ mobilization and neurological recovery in human acute cerebral ischemia.

Methods and Results

PB-MNC-CD34+ were determined daily after an acute cerebral ischemic attack for 14 days in 25 patients with acute ischemic stroke and compared with controls. Results indicated that stroke was followed by large and bursting mobilizations of PB-MNC-CD34+. The amplitude of the mobilizations was similar to those observed in Granulocyte Colony Stimulating Factor (G-CSF) conditioned aplastic patients following myeloablative therapy before leukapheresis and autologous bone graft. The extent of PB-MNC-CD34+ mobilization in each patient was directly related to neurological and functional recoveries as assessed by NIH Stroke Scale, and modified Rankin Scale respectively.

Conclusions

The mobilization of PB-MNC-CD34+ cells might be predictive of neurological and functional recovery.

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Acknowledgement

Authors are very thankful to: Dr Frederic Berthier (from the “Département d’Information Médicale, CHU de Nice) for his valuable contribution in biostatistics; Mr Julien Nivet, Clinical Research Associate; the National Institute of Science and Medical Research and the University Hospital of Nice. We are also very thankful to the “UEFCT’s technicians”.

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Authors and Affiliations

  1. Dept. of Neurology (Stroke Unit), University Hospital Pasteur, 30 avenue de la voie Romaine, Nice Cedex, BP69, 06002, France

    Antoine Dunac MD

  2. Inserm, U615, Nice, 06108, France

    Antoine Dunac MD, Christian Frelin MD, PhD, Marcel Chatel MD, PhD, Marie H. Mahagne MD, PhD & Patrick J.-M. Philip MD

  3. CHRU Nice, Service de Neurologie, Stroke unit, Nice, 06002, France

    Antoine Dunac MD, Margherita Popolo-Blondeau MD, PhD, Marcel Chatel MD, PhD, Marie H. Mahagne MD, PhD & Patrick J.-M. Philip MD

  4. Université de Nice Sophia Antipolis, 06108, France

    Christian Frelin MD, PhD

  5. Dept. d’hématologie, CHRU Nice, Unité d’Exploration Fonctionnelle, Cellulaire et Tissulaire (UEFCT), Nice, 06002, France

    Patrick J.-M. Philip MD

Authors
  1. Antoine Dunac MD
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  2. Christian Frelin MD, PhD
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  3. Margherita Popolo-Blondeau MD, PhD
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  4. Marcel Chatel MD, PhD
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  5. Marie H. Mahagne MD, PhD
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  6. Patrick J.-M. Philip MD
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Corresponding author

Correspondence to Antoine Dunac MD.

Additional information

Financial supports: Centre Hospitalier Universitaire de Nice Sophia Antipolis.

Received in revised form: 21 June 2006

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Dunac, A., Frelin, C., Popolo-Blondeau, M. et al. Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization. J Neurol 254, 327–332 (2007). https://doi.org/10.1007/s00415-006-0362-1

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  • DOI: https://doi.org/10.1007/s00415-006-0362-1

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