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Translational Strategies for Neuroprotection in Ischemic Stroke—Focusing on Acid-Sensing Ion Channel 1a

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Abstract

Ischemic stroke contributes to the majority of brain injuries and remains to be a leading cause of death and long-term disability. Despite the devastating pathology and high incidence of disease, there remain only few treatment options (TPA and endovascular procedures), which may be hampered by time-dependent administration among a variety of other factors. Promising research of glutamate receptor antagonists has been unsuccessful in clinical trial. But, the mechanism by which glutamate receptors initiate injury by excessive calcium overload has spurred investigation of new and potentially successful candidates for stroke therapy. Acid-sensing ion channels (ASICs) may contribute to poor stroke prognosis due to localized drop in brain pH, resulting in excessive calcium overload, independent of glutamate activation. Accumulating studies targeting ASICs have underscored the importance of understanding inhibition, regulation, desensitization, and trafficking of this channel and its role in disease. This review will discuss potential directions in translational ASIC research for future stroke therapies.

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Acknowledgments

The work in ZGX's laboratory was partially supported by NIH R01NS066027, NIMHD S21MD000101, U54 NS083932, AHA 0840132 N, and ALZ IIRG-10-173350.

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The authors declare no conflict of interest

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  1. Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr. SW, Atlanta, GA, 30310, USA

    Zaven O’Bryant, Kiara T. Vann & Zhi-Gang Xiong

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  1. Zaven O’Bryant
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Correspondence to Zhi-Gang Xiong.

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Invited review for special issue: “ion transporters and glutamate receptor-independent mechanisms for ischemic and/or traumatic brain injury.” Guest editors: Dandan Sun and Kristopher Kahle, Translational Stroke Research.

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O’Bryant, Z., Vann, K.T. & Xiong, ZG. Translational Strategies for Neuroprotection in Ischemic Stroke—Focusing on Acid-Sensing Ion Channel 1a. Transl. Stroke Res. 5, 59–68 (2014). https://doi.org/10.1007/s12975-013-0319-5

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