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Design of a Low Voltage TCNQ-Pd-Co@NC-Modified Electrode–Based NADH Sensor

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Abstract

The present work involves the design and validation of an electrochemical sensor for precise and selective sensing of nicotinamide adenine dinucleotide (NADH). The designed electrochemical sensor consists of TCNQ and Pd-Co@NC nanocomposite–modified electrodes (TCNQ-Pd-Co@NC/CPE). The designed electrode was validated by cyclic voltammetry, amperometry, and electrochemical impedance spectroscopy (EIS). The results revealed potent electrocatalytic activity towards NADH oxidation and sensing. Cyclic voltammetry revealed the superior capability of TCNQ-Pd-Co@NC-based carbon paste electrode in electron transfer than TCNQ-Co@NC/CPE and TCNQ/CPE, validating better conductivity of TCNQ-Pd-Co@NC/CPE for NADH sensing. Amperometry study provided a wide linear range of 10 to 250 µM for NADH detection with a low detection limit (LOD) of 5.17 µM and a sensitivity of 21.5 µA mM. EIS study revealed the lowest Rct value of 12.5 × 102 for TCNQ-Pd-Co@NC/CPE compared to TCNQ-Co@NC/CPE and TCNQ/CPE, demonstrating high electron transfer capability and thus sensitivity towards NADH. Besides this, the modified TCNQ-Pd-Co@NC-based carbon paste electrodes offered exceptional selectivity, reproducibility, and stability over time. Therefore, designed TCNQ-Pd-Co@NC nanocomposite–based carbon paste electrodes can be efficiently used for precise and selective NADH sensing.

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Acknowledgements

The author is thankful to CIF IIT BHU for providing a central instrumentation facility. The author is also thankful to the Head of the Department for providing other facilities.

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Authors and Affiliations

  1. Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, 221005, India

    Kuldeep Kumar Maurya, Kulveer Singh, Chitra Singh & Manisha Malviya

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  1. Kuldeep Kumar Maurya
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  2. Kulveer Singh
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  3. Chitra Singh
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  4. Manisha Malviya
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Contributions

K.K.M. made the conception and design of the study and wrote the main manuscript. K.S. and C.S. collected the data and analyzed it. M.M. reviewed and edited the manuscript. All authors reviewed the manuscript.

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Correspondence to Manisha Malviya.

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Maurya, K.K., Singh, K., Singh, C. et al. Design of a Low Voltage TCNQ-Pd-Co@NC-Modified Electrode–Based NADH Sensor. Electrocatalysis (2024). https://doi.org/10.1007/s12678-024-00865-y

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