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The Predictive Values of Five Sarcopenia Screening Tools on Clinical Outcomes Following Surgery in Patients with Gastric Cancer: A Prospective Cohort Study

  • Original Research
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The journal of nutrition, health & aging

Abstract

Background

The association between strength, assistance with walking, rise from a chair, climb stairs and falls (SARC-F), strength, assistance with walking, rise from a chair, climb stairs, falls and calf circumference (SARC-CalF), Ishii score chart, the short version of mini sarcopenia risk assessment (MSRA-5), the full version of mini sarcopenia risk assessment (MSRA-7) and clinical outcomes in patients with gastric cancer were unclear. We aimed to investigate the predictive values of the above five sarcopenia screening tools on clinical outcomes following surgery in patients with gastric cancer.

Methods

The clinical data of consecutive patients who would undergo gastrectomy from May 2020 to October 2020 at the First Affiliated Hospital of Nanjing Medical University were prospectively collected. On the first admission day, patients’ characteristics, Nutrition risk screening 2002 (NRS 2002), the above five sarcopenia screening tools and anthropometric measurements were preoperatively collected. Within 24 hours after discharge, operation information, tumor-node-metastasis (TNM) stage and clinical outcomes in hospital (postoperative complications, hospitalization expenditures and postoperative hospital stay) were collected. Three months after discharge, clinical outcomes out of hospital (hospital readmissions and mortality) were collected. Multivariate analyses were conducted to identify the independent predictors for clinical outcomes.

Results

A total of 263 patients were finally included in the study, with the average age being 62.44 years. The prevalence of sarcopenia risk ranged from 3.42% to 73.76%. For the above five sarcopenia screening tools, multivariate analyses showed that sarcopenia risk indicated by SARC-CalF was an independent predictor for postoperative complications (OR=3.145 [95%CI: 0.594, 16.665], P=0.037), prolonged postoperative hospital stay (B=2.383 [95%CI: 0.377, 4.388], P=0.020), increased hospitalization expenditures (B=1.305 [95%CI: 0.402, 2.208], P=0.005) and 3-month hospital readmissions (HR=3.626 [95%CI: 1.126, 11.676], P=0.031). Sarcopenia risk indicated by Ishii score chart was an independent predictor for postoperative complications (OR=6.491 [95%CI: 1.514, 27.840], P=0.012) and hospitalization expenditures (B=0.767 [95%CI: 0.065, 1.469], P=0.032). Sarcopenia risk indicated by MSRA-7 was an independent predictor for prolonged postoperative hospital stay (B=1.636 [95%CI: 0.119, 3.153], P=0.035)and increased hospitalization expenditures (B=0.831 [95%CI: 0.146, 1.516], P=0.018).

Conclusion

Among the above five sarcopenia screening tools, SARC-CalF seemed to have better predictive values on clinical outcomes. Preoperative gastric cancer patients with sarcopenia risk indicated by SARC-CalF could have a higher risk of postoperative complications, prolonged postoperative hospital stay, increased hospitalization expenditures and 3-month hospital readmissions.

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Acknowledgment

The authors would like to thank all the patient volunteers for their collaborative contribution in this project and for making this study possible.

Funding

Funding: This work was supported by National Natural Science Foundation of China (NSFC) (No. 82073407); NSFC (No. 72004099); People’s Government of Jiangsu Province ((2018) No.87).

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Authors and Affiliations

  1. School of Nursing, Nanjing Medical University, 140 Hanzhong Road, Gulou District, Nanjing, Jiangsu Province, 210029, China

    J.-L. Lu, L.-Y. Ding, J.-M. Hu, W.-Y. Li, Shu-Qin Zhu & Qin Xu

  2. Department of Gastric Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    J.-L. Lu & L. Chen

  3. Faculty of Health, Queensland University of Technology, Brisbane, Australia

    X.-Y. Xu

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  1. J.-L. Lu
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Correspondence to Shu-Qin Zhu or Qin Xu.

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The authors report no conflicts of interest in this work.

These authors are co-first author.

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Lu, JL., Xu, XY., Chen, L. et al. The Predictive Values of Five Sarcopenia Screening Tools on Clinical Outcomes Following Surgery in Patients with Gastric Cancer: A Prospective Cohort Study. J Nutr Health Aging 26, 259–265 (2022). https://doi.org/10.1007/s12603-022-1751-6

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  • DOI: https://doi.org/10.1007/s12603-022-1751-6

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