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Association of Fat Mass with SARC-F in Older Patients Undergoing Haemodialysis

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The journal of nutrition, health & aging

Abstract

Background/Objectives

An increase in fat mass is accompanied by a loss of muscle mass and function in chronic kidney disease. However, no studies in haemodialysis (HD) patients have investigated the relationship between fat mass and sarcopenia. The primary aim of this study is to assess the prevalence of sarcopenia, while the secondary aim is to verify the association between the fat mass percentage and SARC-F and SARC-F combined with calf circumference (SARC-F+CC) in elderly HD patients.

Subjects/Methods

A cross-sectional study enrolled 96 HD older patients (male, n = 66). SARC-F ≥4 is used to define the muscle function loss, whereas SARC-F ≥6 or SARC-F ≥11 (with the calf circumference added) are the thresholds to diagnose sarcopenia. The fat mass percentage is obtained using bioelectrical impedance analysis.

Results

We found that 37.5% had a risk of muscle function loss due to SARC-F ≥4, 21.8% risk of sarcopenia using the SARC-F ≥6, and when using CC, the prevalence of risk of sarcopenia increased to 41.6% according to SARC-F+CC ≥11. In addition, there was an association between adiposity and sarcopenia for SARC-F ≥6 (OR: 1.25, p= 0.028) and SARC-F+CC ≥11 (OR: 1.25, p= 0.0003), but not with muscle function loss (SARC-F ≥4).

Conclusion

In conclusion, we found that 37.5% of HD patients had a risk of muscle function loss and 21–41% presented sarcopenia, depending on the cut-off point used. In addition, higher adiposity was associated with an increased likelihood of having sarcopenia by 25%.

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Acknowledgements

A.C.B.M. would like to thank the Capes, Brazil. G.D.P. would like to The Brazilian National Council for Scientific and Technological Development (CNPq, Brazil, 312252/2019-6).

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Authors and Affiliations

  1. Faculdade de Nutrição, Universidade Federal de Goiás, Rua 227, Quadra 68 s/n∘, Setor Leste Universitario, CEP: 74605-080, Goiânia, GO, Brasil

    R. S. Feitosa, A. C. B. Marini & Gustavo Duarte Pimentel

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  1. R. S. Feitosa
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  2. A. C. B. Marini
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  3. Gustavo Duarte Pimentel
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Contributions

A.C.B.M. and G.D.P. contributed to the study design. A.C.B.M. participated in the collection of data. A.C.B.M., R.S.F., and G.D.P. performed the literature search and discussed the paper. A.C.B.M., R.S.F., and G.D.P. wrote the manuscript. A.C.B.M., G.D.P. participated in critical discussion of data and reviewed the manuscript. All authors critically revised the manuscript, agree to be fully accountable for ensuring the integrity and accuracy of the work, and read and approved the final manuscript.

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Correspondence to Gustavo Duarte Pimentel.

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All authors declare that they have no conflict of interest.

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None declared.

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Feitosa, R.S., Marini, A.C.B. & Pimentel, G.D. Association of Fat Mass with SARC-F in Older Patients Undergoing Haemodialysis. J Nutr Health Aging 26, 183–186 (2022). https://doi.org/10.1007/s12603-022-1737-4

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  • DOI: https://doi.org/10.1007/s12603-022-1737-4

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