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Plasma N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Intrinsic Capacity Decline in an Older Population

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The journal of nutrition, health & aging

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Abstract

Objectives

To determine the association between plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and intrinsic capacity in an older population.

Method

We recruited 283 participants aged 60∓97 years (mean 77.42±4.08 years). Intrinsic capacity was assessed with the World Health Organization Integrated Care for Older People (ICOPE) screening tool including six domains: cognition, locomotion, vitality, hearing, vision, and psychology. Multimorbidity, polypharmacy, gait speed, physical activity, lifestyles, and chronic inflammation were assessed. We used multivariate logistic regression and the Spearman’s correlation to assess the association between plasma NT-proBNP and intrinsic capacity.

Results

The average intrinsic capacity score was 4.53±1.34. The percentage of decreased intrinsic capacity was 75.3%. Participants with decreased intrinsic capacity were older, with more cardiovascular and cerebrovascular diseases and polypharmacy, and had lower gait speed and higher C-reactive protein. Plasma NT-proBNP was significantly higher in the decreased intrinsic capacity group (128.0[56.8∓280.8] pg/mL vs. 72.6[39.7∓120.0] pg/mL, p<0.001). Multivariate logistic regression analysis revealed that NT-proBNP was the only independent risk factor for decreased intrinsic capacity among multiple covariates (odds ratio=1.005, p=0.038). Elevated NT-proBNP levels were associated with abnormal locomotion, hearing, vision, and psychology domains. Additionally, NT-proBNP levels were inversely correlated with the intrinsic capacity score adjusted for both age and coronary artery disease (r=−0.371, p< 0.001).

Conclusion

Elevated NT-proBNP levels were associated with decreased intrinsic capacity in older persons, independent of age, multimorbidity, polypharmacy, and chronic inflammation. Further longitudinal studies are required to explore the predictive role of NT-proBNP on declines in intrinsic capacity.

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Acknowledgments

We thank Drs. Yumeng Chen, Yu Song, Ou Zhao, Bixi Li and Chuan Liu for their assistance in data collection, entry, and study coordination and all member of the team. We acknowledge all the people who participated in the study.

Funding

Funding: This work was supported by the following grants: National Key R&D Program of China (2018YFC1312001), the National Natural Science Foundation of Beijing (7202059), Beijing Municipal Hospital Scientific Research Training Project (PX2020036), and Milstein Medical Asian American Partnership Foundation Project Award in Geriatrics (2018).

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Authors and Affiliations

  1. Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Research Center for Geriatric Medicine, Beijing, China

    Lina Ma, Y. Zhang, P. Liu, S. Li, Y. Li, T. Ji, L. Zhang & Y. Li

  2. Department of Neurology and Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing, China

    J. K. Chhetri

Authors
  1. Lina Ma
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  2. Y. Zhang
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  3. P. Liu
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  4. S. Li
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  5. Y. Li
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  6. T. Ji
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  7. L. Zhang
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  8. J. K. Chhetri
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  9. Y. Li
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Contributions

Author Contributions: LM contributed to the design of the work. LM drafted the manuscript and wrote it together with JC. YZ, PL, SL, YL, and TJ recruited the participants. LM, JC, LZ and YL contributed to the analysis and interpretation of data. All the authors contributed to writing the paper and revising it critically and gave final approval of this version.

Corresponding author

Correspondence to Lina Ma.

Ethics declarations

Conflict of interest statement: There are no ethical/legal conflicts involved in the article.

Ethical standards: The present study followed the ethical guideline of the declaration of Helsinki and was approved by the Ethics Committees.

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Ma, L., Zhang, Y., Liu, P. et al. Plasma N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Intrinsic Capacity Decline in an Older Population. J Nutr Health Aging 25, 271–277 (2021). https://doi.org/10.1007/s12603-020-1468-3

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  • DOI: https://doi.org/10.1007/s12603-020-1468-3

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