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Inverse association between dietary habits with high total antioxidant capacity and prevalence of frailty among elderly Japanese women: A multicenter cross-sectional study

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The journal of nutrition, health & aging

Abstract

Objective

To examine the association of dietary habits with high total antioxidant capacity (TAC) with frailty among elderly Japanese women.

Design

Cross-sectional multicenter study.

Setting

Thirty-five of 47 prefectures in Japan.

Participants

2121 grandmothers or acquaintances of dietetic students aged 65 and older.

Measurements

Dietary TAC and food intakes were calculated using a validated brief-type self-administered diet history questionnaire. The TAC value of each food was assigned using four different assays, ferric reducing ability of plasma (FRAP), oxygen radical absorbance capacity (ORAC), Trolox equivalent antioxidant capacity (TEAC), and total radical-trapping antioxidant parameter (TRAP). Frailty was defined as the presence three or more of the following four components: slowness and weakness (two points), exhaustion, low physical activity, and unintentional weight loss.

Results

The number of subjects with frailty was 486 (23%). Multivariate adjusted ORs (95% CI) for frailty in the highest compared to the lowest quintile were 0.35 (0.24, 0.53) for FRAP, 0.35 (0.23, 0.52) for ORAC, 0.40 (0.27, 0.60) for TEAC, and 0.41 (0.28, 0.62) for TRAP. The intakes of green tea, coffee, vegetables, and fruits which contribute to dietary TAC were also associated with lower odds of frailty (the range of multivariate adjusted OR: 0.47 for vegetables to 0.77 for green tea), although the odds ratios were less marked than those of dietary TAC.

Conclusions

Dietary habits with high TAC showed a stronger inverse association with frailty in elderly Japanese women than the individual foods examined.

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References

  1. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56:M146–M156

    Article  CAS  PubMed  Google Scholar 

  2. Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc 2012;60:1487–1492

    Article  PubMed  Google Scholar 

  3. Nemoto M, Yabushita N, Kim MJ, Matsuo T, Seino S, Tanaka K. Assessment of vulnerable older adults’ physical function according to the Japanese Long-Term Care Insurance (LTCI) system and Fried’s criteria for frailty syndrome. Arch Gerontol Geriatr 2012;55:385–391

    Article  PubMed  Google Scholar 

  4. Doba N, Tokuda Y, Goldstein NE, Kushiro T, Hinohara S. A pilot trial to predict frailty syndrome: the Japanese Health Research Volunteer Study. Exp Gerontol 2012;47:638–643

    Article  PubMed  Google Scholar 

  5. Murayama H, Nishi M, Shimizu Y et al. The hatoyama cohort study: design and profile of participants at baseline. J Epidemiol 2012;22:551–558

    Article  PubMed  Google Scholar 

  6. National Institute on Aging, National Institutes of Health, US Department of Health and Human Services 2011 Global health and ageing. http://www.who.int/ageing/publications/global_health/en/ Accessed 4 November 2013

  7. Lee PH, Lee YS, Chan DC. Interventions targeting geriatric frailty: A systemic review. J Clin Gerontol Geriatr 2012;3:47–52

    Article  CAS  Google Scholar 

  8. Chan DC, Tsou HH, Yang RS et al. A pilot randomized controlled trial to improve geriatric frailty. BMC Geriatr 2012;12:58

    Article  PubMed Central  PubMed  Google Scholar 

  9. Hsiao PY, Mitchell DC, Coffman DL et al. Dietary patterns and diet quality among diverse older adults: the University of Alabama at Birmingham Study of Aging. J Nutr Health Aging 2013;17:19–25

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Dent E, Visvanathan R, Piantadosi C et al. Use of the Mini Nutritional Assessment to detect frailty in hospitalised older people. J Nutr Health Aging 2012;16:764–767

    Article  CAS  PubMed  Google Scholar 

  11. Mulero J, Zafrilla P, Martinez Cacha A. Oxidative stress, frailty and cognitive decline. J Nutr Health Aging 2011;15:756–760

    Article  CAS  PubMed  Google Scholar 

  12. Kaiser MJ, Bandinelli S, Lunenfeld B. The nutritional pattern of frailty — Proceedings from the 5th Italian Congress of Endocrinology of Aging, Parma, Italy, 2009;27–28 March 2009. Aging Male 12:87–94

  13. Ble A, Cherubini A, Volpato S et al. Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2006;61:278–283

    Article  PubMed  Google Scholar 

  14. Michelon E, Blaum C, Semba RD, Xue QL, Ricks MO, Fried LP. Vitamin and carotenoid status in older women: associations with the frailty syndrome. J Gerontol A Biol Sci Med Sci 2006;61:600–607

    Article  PubMed  Google Scholar 

  15. Semba RD, Bartali B, Zhou J, Blaum C, Ko CW, Fried LP. Low serum micronutrient concentrations predict frailty among older women living in the community. J Gerontol A Biol Sci Med Sci 2006;61:594–599

    Article  PubMed  Google Scholar 

  16. Bartali B, Frongillo EA, Bandinelli S et al. Low nutrient intake is an essential component of frailty in older persons. J Gerontol A Biol Sci Med Sci 2006;61:589–593

    Article  PubMed Central  PubMed  Google Scholar 

  17. Stanner SA, Hughes J, Kelly CN, Buttriss J. A review of the epidemiological evidence for the’ antioxidant hypothesis’. Public Health Nutr 2004;7:407–422

    Article  CAS  PubMed  Google Scholar 

  18. Pellegrini N, Salvatore S, Valtuena S et al. Development and validation of a food frequency questionnaire for the assessment of dietary total antioxidant capacity. J Nutr 2007;137:93–98

    CAS  PubMed  Google Scholar 

  19. Ghiselli A, Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med 2000;29:1106–1114

    Article  CAS  PubMed  Google Scholar 

  20. Brighenti F, Valtuena S, Pellegrini N et al. Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects. Br J Nutr 2005;93:619–625

    Article  CAS  PubMed  Google Scholar 

  21. Detopoulou P, Panagiotakos DB, Chrysohoou C et al. Dietary antioxidant capacity and concentration of adiponectin in apparently healthy adults: the ATTICA study. Eur J Clin Nutr 2010;64:161–168

    Article  CAS  PubMed  Google Scholar 

  22. Hermsdorff HH, Zulet MA, Puchau B, Martinez JA. Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutr Metab (Lond) 2010;7:42

    Article  Google Scholar 

  23. Valtuena S, Pellegrini N, Franzini L et al. Food selection based on total antioxidant capacity can modify antioxidant intake, systemic inflammation, and liver function without altering markers of oxidative stress. Am J Clin Nutr 2008;87:1290–1297

    CAS  PubMed  Google Scholar 

  24. Kobayashi S, Murakami K, Sasaki S et al. Dietary total antioxidant capacity from different assays in relation to serum C-reactive protein among young Japanese women. Nutr J 2012;11:91

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Ministry of Health, Labour, and Welfare. Dietary Reference Intakes for Japanese. 2010. Ministry of Health and Welfare, Tokyo (in Japanese), 2009.

    Google Scholar 

  26. Kobayashi S, Murakami K, Sasaki S et al. Comparison of relative validity of food group intakes estimated by comprehensive and brief-type self-administered diet history questionnaires against 16 d dietary records in Japanese adults. Public Health Nutr 2011;14:1200–1211

    Article  PubMed  Google Scholar 

  27. Kobayashi S, Honda S, Murakami K et al. Both comprehensive and brief self-administered diet history questionnaires satisfactorily rank nutrient intakes in Japanese adults. J Epidemiol 2012;22:151–159

    Article  PubMed Central  PubMed  Google Scholar 

  28. Science and Technology Agency, 2010. Standard Tables of Food Composition in Japan, 2010. Ministry of Education, Culture, Sports, Science and Technology, Tokyo (in Japanese)

    Google Scholar 

  29. Woods NF, LaCroix AZ, Gray SL et al. Frailty: emergence and consequences in women aged 65 and older in the Women’s Health Initiative Observational Study. J Am Geriatr Soc 2005;53:1321–1330

    Article  PubMed  Google Scholar 

  30. Fukuhara S, Bito S, Green J, Hsiao A, Kurokawa K. Translation, adaptation, and validation of the SF-36 Health Survey for use in Japan. J Clin Epidemiol 1998;51:1037–1044

    Article  CAS  PubMed  Google Scholar 

  31. Fukuhara S, Ware JE Jr, Kosinski M, Wada S, Gandek B. Psychometric and clinical tests of validity of the Japanese SF-36 Health Survey. J Clin Epidemiol 1998;51:1045–1053

    Article  CAS  PubMed  Google Scholar 

  32. Fukuhara S, Suzukamo Y, 2004. Manual of SF-36v2 Japanese version. Institute for Health Outcomes & Process Evaluation Research, Kyoto (in Japanese)

    Google Scholar 

  33. Ainsworth BE, Haskell WL, Herrmann SD et al. 2011 compendium of physical activities: a second update of codes and MET values. Med Sci Sports Exerc 2011;43:1575–1581

    Article  PubMed  Google Scholar 

  34. Wada K, Tanaka K, Theriault G et al. Validity of the Center for Epidemiologic Studies Depression Scale as a screening instrument of major depressive disorder among Japanese workers. Am J Ind Med 2007;50:8–12

    Article  PubMed  Google Scholar 

  35. Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977;1:385–401

    Article  Google Scholar 

  36. Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986;124:17–27

    CAS  PubMed  Google Scholar 

  37. Niu K, Hozawa A, Kuriyama S et al. Green tea consumption is associated with depressive symptoms in the elderly. Am J Clin Nutr 2009;90:1615–1622

    Article  CAS  PubMed  Google Scholar 

  38. Chen X, Lu W, Zheng Y et al. Exercise, tea consumption, and depression among breast cancer survivors. J Clin Oncol 2010;28:991–998

    Article  PubMed Central  PubMed  Google Scholar 

  39. Lakey SL, Lacroix AZ, Gray SL et al. Antidepressant use, depressive symptoms, and incident frailty in women aged 65 and older from the Women’s Health Initiative Observational Study. J Am Geriatr Soc 2012;60:854–861

    Article  PubMed Central  PubMed  Google Scholar 

  40. Hubbard RE, Lang IA, Llewellyn DJ, et al. Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci 2010;65:377–381

    Article  PubMed  Google Scholar 

  41. Bollwein J, Diekmann R, Kaiser MJ et al. Dietary quality is related to frailty in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2013;68:483–489

    Article  PubMed  Google Scholar 

  42. Talegawkar SA, Bandinelli S, Bandeen Roche K et al. A higher adherence to a mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women. J Nutr 2012;142:2161–2166

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  43. Kolomvotsou Al, Rallidis LS, Mountzouris KC et al. Adherence to Mediterranean diet and close dietetic supervision increase total dietary antioxidant intake and plasma antioxidant capacity in subjects with abdominal obesity. Eur J Nutr 2013;52:37–48

    Article  CAS  PubMed  Google Scholar 

  44. La Vecchia C, Decarli A, Serafini M et al. Dietary total antioxidant capacity and colorectal cancer: A large case-control study in Italy. Int J Cancer 2013;133:1447–1451

    Article  CAS  PubMed  Google Scholar 

  45. Takebayashi J, Oki T, Chen J et al. Estimated average daily intake of antioxidants from typical vegetables consumed in Japan: a preliminary study. Biosci Biotechnol Biochem 2010;74:2137–2140

    Article  CAS  PubMed  Google Scholar 

  46. Pellegrini N, Serafini M, Colombi B et al. Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays. J Nutr 2003;133:2812–2819

    CAS  PubMed  Google Scholar 

  47. Rautiainen S, Serafini M, Morgenstern R, Prior RL, Wolk A. The validity and reproducibility of food-frequency questionnaire-based total antioxidant capacity estimates in Swedish women. Am J Clin Nutr 2008;87:1247–1253

    CAS  PubMed  Google Scholar 

  48. Serafini M, Del Rio D. Understanding the association between dietary antioxidants, redox status and disease: is the Total Antioxidant Capacity the right tool? Redox Rep 2004;9:145–152

    Article  CAS  PubMed  Google Scholar 

  49. Carlsen MH, Halvorsen BL, Holte K et al. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J 2010;9:3

    Article  PubMed Central  PubMed  Google Scholar 

  50. Ministry of Education, Culture, Sports, and Technology. General Survey of Schools. 2012 (in Japanese) http://www.mext.go.jp/component/b_menu/other/icsFiles/afieldfile/2012/12/21/1329238_l_l.pdf Accessed 21 March 2013

    Google Scholar 

  51. Raji MA, Al Snih S, Ostir GV, Markides KS, Ottenbacher KJ. Cognitive status and future risk of frailty in older Mexican Americans. J Gerontol A Biol Sci Med Sci 2010;65:1228–1234

    Article  PubMed  Google Scholar 

  52. Devore EE, Kang JH, Stampfer MJ, Grodstein F. Total antioxidant capacity of diet in relation to cognitive function and decline. Am J Clin Nutr 2010;92:1157–1164.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Social and Preventive Epidemiology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

    S. Kobayashi, H. Suga & S. Sasaki

  2. Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    K. Asakura & S. Sasaki

  3. Interfaculty Initiative in Information Studies, the University of Tokyo, Tokyo, Japan

    K. Asakura

Authors
  1. S. Kobayashi
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  2. K. Asakura
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  4. S. Sasaki
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The Three-Generation Study of Women on Diets and Health Study Groups

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Correspondence to S. Sasaki.

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Kobayashi, S., Asakura, K., Suga, H. et al. Inverse association between dietary habits with high total antioxidant capacity and prevalence of frailty among elderly Japanese women: A multicenter cross-sectional study. J Nutr Health Aging 18, 827–836 (2014). https://doi.org/10.1007/s12603-014-0556-7

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  • DOI: https://doi.org/10.1007/s12603-014-0556-7

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