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Oxidative stress, frailty and cognitive decline

  • Oxidative Stress, Frailty and Cognitive Decline
  • Published:
The journal of nutrition, health & aging

Abstract

Abstract

The causes of frailty are complex and must be accepted as multidimensional based on the interplay of genetic, biological, physical, psychological, social and environmental factors, although inflammation and oxidative stress are two factors that play an important role in the development of symptoms with those fragile states.

Objective

To establish the relationship between oxidative stress, frailty and decline cognitive.

Methods

A review of the literature and data abstraction from papers are showing the relationship between a) oxidative stress and frailty, b) oxidative stress and decline cognitive.

Results

The papers reviewed showed that we can establish a relationship between the progress of neurodegenerative disorders and increased oxidative stress. Also found in frailty, that oxidative stress plays an important role as one of the starting points for the appearance of permanent inflammatory states.

Conclusions

Although the literature indicates the relationship between oxidative stress, frailty and decline cognitive, more studies are needed in this regard, especially interventions that asses whether increased intake of antioxidants in older frailty may improve the progress of disease and slow cognitive decline.

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References

  1. Christensen K, McGue M, Petersen I, Jeune B, Vaupel JW (2008) Exceptional longevity does not result in excessive levels of disability. Proc Natl Acad Sci U S A 105:13274–13279

    Article  PubMed  CAS  Google Scholar 

  2. Fulop T, A Larbi A, Witkowski JM, McElhaney J, Loeb M, Mitnitski A, Pawelec G (2010) Aging, frailty and age-related diseases. Biogerontology 11:547–563

    Article  PubMed  CAS  Google Scholar 

  3. Montesanto A, Lagani V, Martino C, Dato S, De Rango F, Berardelli M, Corsonello A, Mazzei B, Mari V, Lattanzio F, Conforti D, Pass G (2010) A novel, populationspecific approach to define frailty. AGE 32:385–395

    Article  PubMed  Google Scholar 

  4. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA (2001) Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56: 146–156

    Article  Google Scholar 

  5. Fried LP, Walston J (2003) Frailty and failure to thrive. In: Hazzard WR, Blass JP, Ettinger WHJr, Halter JB, Ouslander J (eds) Principles of geriatric medicine and gerontology, 5th edn. McGraw-Hill, New York, pp 1487–1502

    Google Scholar 

  6. Bandeen-Roche K, Walston JD, Huang Y, Semba RD, Ferrucci L (2009) Measuring systemic inflammatory regulation in older adults: evidence and utility. Rejuvenation Res 12(6):403–410

    Article  PubMed  Google Scholar 

  7. Bergman H, Ferrucci L, Guralnik J, Hogan D, Hummel S, Karunananthan S, Wolfson C (2007) Frailty: an emerging research and clinical paradigm-issues and controversies. J Gerontol A Biol Sci Med Sci 62(7):731–737

    Article  PubMed  Google Scholar 

  8. Kanapuru B, Ershler WB (2009) Inflammation, coagulation, and the pathway to frailty. Am J Med 122(7):605–613

    Article  PubMed  CAS  Google Scholar 

  9. Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA, Ershler WB, Harris T, Fried LP (2006) Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 54:991–1001

    Article  PubMed  Google Scholar 

  10. Levers MJ, Estabrooks CA, Ross Kerr JC (2006) Factors contributing to frailty: literature review. J Adv Nurs 56:282–291

    Article  PubMed  Google Scholar 

  11. Ottenbacher KJ, Ostir GV, Peek MK, Snih SA, Raji MA, Markides KS (2005) Frailty in older mexican americans. J Am Geriatr Soc 53:1524–1531.

    Article  PubMed  Google Scholar 

  12. Buchman AS, Boyle PA, Wilson RS, Leurgans SE, Bennett DA (2007) Frailty is associated to with incident Alzheimer’s disease and cognitive decline in elderly. Psychosom Med 69:483–489.

    Article  PubMed  Google Scholar 

  13. Samper-Ternent R, Al Snih S, Raji MA, Markides KS, Ottenbacher KJ (2008). Relationship between Frailty and Cognitive Decline in Older Mexican Americans. J Am Geriatr Soc 56(10): 1845–1852

    Article  PubMed  Google Scholar 

  14. Rockwood K, Mitnitski A (2007) Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci 62(7):722–727

    Article  PubMed  Google Scholar 

  15. Ble A, Cherubini A, Volpato S, Bartali B, Walston JD, Windham BG, Bandinelli S, Lauretani F, Guralnik JM, Ferrucci L (2006) Lower Plasma Vitamin E Levels Are Associated With the Frailty Syndrome: The InCHIANTI Study J Gerontol A Biol Sci Med Sci 61(3): 278–283.

    Article  PubMed  Google Scholar 

  16. Hunt KJ, Walsh BM, Voegeli D, Roberts HC (2010) Inflammation in aging part 1: physiology and immunological mechanisms. Biol Res Nurs 11:245–252

    Article  PubMed  CAS  Google Scholar 

  17. Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Castellani GC, Salvioli S (2007) Inflammaging and antiinflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128:92–105

    Article  PubMed  CAS  Google Scholar 

  18. Barzilay JI, Blaum C, Moore T, Xue QL, Hirsch CH, Walston JD, Fried LP (2007) Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health study. Arch Intern Med, 167: 635–41

    Article  PubMed  Google Scholar 

  19. Espinoza S, Walston JD (2005) Frailty in older adults: Insights and interventions. Cleve Clin J Med 72(12):1105–1112.

    Article  PubMed  Google Scholar 

  20. Ershler WB, Keller ET (2000) Age-associated increased interleukin-6 gene expression, late-life diseases and frailty. Ann Rev Med 51:245–270

    Article  PubMed  CAS  Google Scholar 

  21. Cesari M, Penninx BW, Pahor M, Lauretani F, Corsi AM, Rhys Williams G, Guralnik JM, Ferrucci L (2004) Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 59:242–248

    Article  PubMed  Google Scholar 

  22. Ferrucci L, Harris TB, Guralnik JM, Tracy RP, Corti MC, Cohen HJ, Penninx B, Pahor M, Wallace R, Havlik RJ (1999) Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc 47:639–646

    PubMed  CAS  Google Scholar 

  23. Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH, Gottdiener J, Fried LP (2002) Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med 162:2333–2341

    Article  PubMed  Google Scholar 

  24. Leng SX, Xue Q-L, Tian J, Walston JD, Fried LP (2007) Inflammation and frailty in older women. J Am Geriatr Soc 55:864–871

    Article  PubMed  Google Scholar 

  25. Maggio M, Guralnik JM, Longo DL, Ferrucci L (2006) Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol Med Sci 61:575–584

    Article  Google Scholar 

  26. Kregel KC, Zhang HJ (2007) An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol 292: 18–36

    Article  Google Scholar 

  27. Howard C, Ferrucci L, Sun K, Fried LP, Walston J, Varadhan R, Guralnik JM, Semba RD (2007) Oxidative protein damage is associated with poor grip strength among older women living in the community. J Appl Physiol 103: 17–20

    Article  PubMed  CAS  Google Scholar 

  28. Serviddio G, Romano AD, Greco A, Rollo T, Bellanti F, Altomare E, Vendemiale G (2009) Frailty syndrome is associated with altered circulating redox balance and increased markers of oxidative stress. Int J Immunopathol Pharmacol. 22:819–827

    PubMed  CAS  Google Scholar 

  29. Wu IC, Shiesh SC, Kuo PH, Lin XZ (2009) High oxidative stress is correlated with frailty in elderly chinese. J Am Geriatr Soc 57:1666–1671

    Article  PubMed  Google Scholar 

  30. Reid MB, Li YP (2001) Tumor necrosis factor-alpha and muscle wasting: a cellular perspective. Respir Res 2: 269–272

    Article  PubMed  CAS  Google Scholar 

  31. Carter CS, Hofer T, Seo AY, Leeuwenburgh C (2007). Molecular mechanisms of life- and health-span extension: role of calorie restriction and exercise intervention. Appl Physiol Nutr Metab 32:954–966

    Article  PubMed  CAS  Google Scholar 

  32. Giorgio M, Trinei m, Migliaccio E, Pelicci PG (2007) Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?. Nat Rev Mol Cell Biol 8: 722–728.

    Article  PubMed  CAS  Google Scholar 

  33. Kowaltowski Aj, Castilho RF, Vercesi AE (2001) Mitochondrial permeability transition and oxidative stress. FEBS Lett 495: 12–15

    Article  PubMed  CAS  Google Scholar 

  34. Paravicini TM, Touyz RM (2006) Redox signalin in hypertension. Caardiovasc Res 71: 247–258.

    Article  CAS  Google Scholar 

  35. Trujillo ME, Scherer PE (2006) Adipose tissue-derived factors: impact on health and disease. Endocr Rev 27: 762–778.

    PubMed  CAS  Google Scholar 

  36. Despre’s JP, Lemieux I, Bergeron J Pibarot P, Mathieu P, Larose E (2008) Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol 28:1039–1049

    Article  Google Scholar 

  37. Pou KM, Massaro JM, Hoffmann U Vasan RS, Maurovich-Horvat P, Larson MG (2007) Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation 116:1234–1241

    Article  PubMed  CAS  Google Scholar 

  38. Fulop T, Tessier D, Carpentier A (2006) The metabolic syndrome. Pathol Biol 54(7):375–386

    Article  PubMed  CAS  Google Scholar 

  39. Park DC, Reuter-Lorenz P (2009) The adaptive brain: aging and neurocognitive scaffolding. Annu Rev Psychol 60: 173–196

    Article  PubMed  Google Scholar 

  40. Wolf H, Hensel A, Kruggel F, Riedel-Heller SG, Arendt T, Wahlund LO, Gertz HJ (2004) Structural correlates of mild cognitive impairment. Neurobiol Aging 25: 913–924.

    Article  PubMed  Google Scholar 

  41. Gallagher M, Landfield PW, McEwen B (1996) Hippocampal neurodegeneration in aging. Science 274: 484–485.

    Article  PubMed  CAS  Google Scholar 

  42. Schütt A, Bullock TH, Başar E (1999) Dynamics of potentials from Invertebrate brains. In: Başar, E. (Ed.), Brain Function and Oscillations: II. Integrative Brain Function. Neurophysiology and Cognitive Processes. Springer-Verlag, Heidelberg, pp. 91–108.

    Google Scholar 

  43. Rinaldi P, Polidori MC, Metasstasio A (2003) Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease. Neurobiol Aging 24: 915–919

    Article  PubMed  CAS  Google Scholar 

  44. Fraser HB, Khaitovich P, Plotkin JB, Paabo S, Eisen MB (2005) Aging and gene expression in the primate brain. Plos Biol 3, e274.

    Article  PubMed  Google Scholar 

  45. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H (2007) Trends in oxidative aging theories. Free Radic Biol Med 43: 477–503

    Article  PubMed  CAS  Google Scholar 

  46. Yankner B A, Lu T, Loerch P (2008) The aging brain. Annu Rev Pathol 3: 41–66

    Article  PubMed  CAS  Google Scholar 

  47. Wallace DC (1999) Mitochondrial diseases in man and mouse. Science 283: 1482–1488.

    Article  PubMed  CAS  Google Scholar 

  48. Migliore L, Fontana I, Trippi F, Colognato R, Coppedè F, Tognoni G, Nucciarone B, Siciliano G (2005) Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. Neurobiology of aging 26: 567–573

    Article  PubMed  CAS  Google Scholar 

  49. Practico D, Clark C, Liun F, Lee V, Trojanowski J (2002) Increase of Brain Oxidative Stress in Mild Cognitive Impairment. A Possible Predictor of Alzheimer Disease. Arch Neurol 59:972–976.

    Article  Google Scholar 

  50. Wang J, Xiong S, Xie C, Markesbery WR, Lovell M A (2005) Increased oxidative damage in nuclear and mithochondrial DNA in Alzheimer’s disease. J. Neurochem. 93: 953–962

    Article  PubMed  CAS  Google Scholar 

  51. Mohsen MMAE, Iravani MM, Spencer JPE, Rose S, Fahim AT, Motawi TMK, Ismail NAF, Jenner P (2005) Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants. Biochemical & Biophysical Res. Communications 336: 386–391

    Article  Google Scholar 

  52. Poon HF, Calabrese V, Calvani M, Butterfield DA (2006) Proteomics Analyses of Specific Protein Oxidation and Protein Expression in Aged Rat Brain and Its Modulation by L-Acetylcarnitine: Insights Into the Mechanisms of Action of This Proposed Therapeutic Agent for CNS Disorders Associated with Oxidative Stress. Antioxid Redox Signal 8: 381–394

    Article  PubMed  CAS  Google Scholar 

  53. Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120: 483–495

    Article  PubMed  CAS  Google Scholar 

  54. Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443: 787–795

    Article  PubMed  CAS  Google Scholar 

  55. Liu R, Liu IY, Bi X, Thompson RF, Doctrow SR, Malfroy B, Baudry M (2003) Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc Natl Acad Sci USA 100: 8526–8531.

    Article  PubMed  CAS  Google Scholar 

  56. Sigueira IR, Fochesatto C, Lucena da Silva Torres I, Dalmaz C, Netto CA (2005) Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats. Life Sci 78: 271–278.

    Article  Google Scholar 

  57. Navarro A, Gomez C, Lopez-Cepero JM, Boveris A (2004) Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer. Am J Physiol Regul Integr Comp Physiol 286: 505–511.

    Article  Google Scholar 

  58. Richwine AF, Godbout JP, Berg BM, Chen J, Escobar J, Millard DK, Johnson RW (2005) Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo brain interleukin-6 production. Brain Behav Immun 19: 512–520.

    Article  PubMed  CAS  Google Scholar 

  59. Dröge W, Schipper HM (2007) Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell 6: 361–370

    Article  PubMed  Google Scholar 

  60. Joseph JA, Shukitt-Hale B, Casadeus G, Fisher D (2005) Oxidative stress and inflammation in brain aging: Nutritonal Cons Neurochem Res 30: 927–935

    Article  CAS  Google Scholar 

  61. Scarmeas N, Luchsinger JA, Schupf N, Brickman AM, Cosentino S, Tang MX (2009) Physical activity, diet and Alzheimer’s disease risk. JAMA 302:2431–2431

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Food Technology and Nutrition, Catholic University of San Antonio, Murcia, 30107, Spain

    J. Mulero, P. Zafrilla & A. Martinez-Cacha

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  1. J. Mulero
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  2. P. Zafrilla
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  3. A. Martinez-Cacha
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Correspondence to J. Mulero.

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Mulero, J., Zafrilla, P. & Martinez-Cacha, A. Oxidative stress, frailty and cognitive decline. J Nutr Health Aging 15, 756–760 (2011). https://doi.org/10.1007/s12603-011-0130-5

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  • DOI: https://doi.org/10.1007/s12603-011-0130-5

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