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Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea

  • Published:
The journal of nutrition, health & aging

Abstract

Background

Obstructive sleep apnea (OSA) is associated with increased oxidative stress. Certain essential trace minerals have shown to play an important role in the maintenance of redox homeostasis. We determined the concentrations of trace minerals in OSA patients and assessed their relationships to OSA severity as indicated by the apnea/hypopnea index (AHI).

Methods

We enrolled 44 patients with newly diagnosed mild to moderate OSA and 20 without OSA. The following parameters were measured: polysomnographic values of nocturnal sleep; plasma trace minerals zinc (Zn), copper (Cu), iron (Fe), and erythrocyte selenium (Se); oxidative stress status; and plasma high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α).

Results

Compared to controls matched for age, gender, and body mass index, OSA patients had lower concentrations of plasma Zn and erythrocyte Se and higher plasma concentrations of Cu and Fe. OSA patients had significantly higher plasma concentrations of hs-CRP, TNF-α, and malondialdehyde (MDA), and lower erythrocyte antioxidant enzyme glutathione peroxidase (GPx) and superoxide dismutase activities. Significant differences in all the above parameters were also found in patients with moderate OSA compared to those with mild OSA. Furthermore, AHI values correlated significantly with neck circumference, GPx activity, and MDA, hs-CRP, and TNF-α concentrations in OSA patients. AHI values were also negatively associated with concentrations of plasma Zn and erythrocyte Se, but were positively linked to plasma concentrations of Fe and Cu.

Conclusions

Abnormal concentrations of these trace minerals may reflect oxidative damage and inflammatory response, thus increasing the severity of OSA.

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Authors and Affiliations

  1. Biomedical Nutrition & Micro-Nutrition Labs, Institute of Biomedical Nutrition, Hung Kuang University, Taichung, 433, Taiwan, Republic of China

    P. -C. Chen & C. -H. Guo

  2. Nutrition Room, Yuan-Rung General Hospital, Changhua, 510, Taiwan, Republic of China

    C. -J. Tseng

  3. Department of Otolaryngology, Cheng-Ching Hospital, Taiwan Boulevard, Taichung, 407, Taiwan, Republic of China

    K. -C. Wang

  4. Department of Otolaryngology & Nutrition and Naturopathic center, Cheng-Ching Hospital, Taiwan Boulevard, Taichung, 407, Taiwan, Republic of China

    Po-Jen Liu

  5. School of Nutrition, Chung Shan Medical University, Taichung, 402, Taiwan, Republic of China

    Po-Jen Liu

Authors
  1. P. -C. Chen
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  2. C. -H. Guo
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  3. C. -J. Tseng
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Correspondence to Po-Jen Liu.

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Chen, P.C., Guo, C.H., Tseng, C.J. et al. Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea. J Nutr Health Aging 17, 639–644 (2013). https://doi.org/10.1007/s12603-013-0023-x

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  • DOI: https://doi.org/10.1007/s12603-013-0023-x

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