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Metal-based inorganic nanocrystals for biological sonodynamic therapy applications: recent progress and perspectives

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Abstract

With the fast development of technology for the treatment of tumor and bacteria, photo-therapeutic strategies emerge as a kind of highly effective and common treatment, but the low tissue penetration depth of light limits their development. Sonodynamic therapy (SDT), as an efficient and non-invasive treatment, attracts more people's attention due to the inherent property of high tissue penetration. The soft tissue penetration depth of ultrasound (US) can even reach more than 10 cm, which has great advantage over that of light. Therefore, many sonosensitizers are studied and applied to SDT-based therapy. Metal-based inorganic nanocrystals are able to generate more reactive oxygen species (ROS) due to the special composition and band structure. The representative achievements and the specific functions of the nanocrystals sonosensitizers are summarized in this work, and the relationship of structure/composition-SDT performance and the internally regulated composite is revealed. Synergistic effects of SDT in combination with other therapeutic modalities are mainly highlighted. At the same time, the critical and potential issues and future perspectives are addressed.

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摘要

随着肿瘤和细菌治疗技术的飞速发展，光疗策略作为一种高效常用的治疗手段应运而生，但光的组织穿透深度低限制了其发展。声动力疗法（SDT）作为一种高效、无创的治疗方法，由于具有高组织穿透性的固有特性而受到更多人的关注。超声（US）的软组织穿透深度甚至可以达到10厘米以上，相比光有很大的优势。因此，许多声敏剂被研究并应用于SDT 的治疗。由于特殊的成分组成和能带结构，金属基无机纳米晶体能够产生更多的活性氧（ROS）。我们总结了这些纳米晶体声敏剂的代表性成果和具体功能，结构/组成与SDT性能与内部调节复合材料的关系。主要强调了 SDT 与其他治疗方式的协同作用。同时，也对关键和潜在的问题以及未来的前景进行了阐述

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Scheme 1
Fig. 1

Reproduced with permission from Ref. [49]. Copyright 2016, American Chemical Society

Fig. 2

Reproduced with permission from Ref. [53]. Copyright 2018, the Royal Society of Chemistry

Fig. 3

Reproduced with permission from Ref. [62]. Copyright 2020, Ivyspring International Publisher

Fig. 4

Reproduced with permission from Ref. [27]. Copyright 2017, American Chemical Society

Fig. 5

Reproduced with permission from Ref. [70]. Copyright 2020, American Chemical Society

Fig. 6

Reproduced with permission from Ref. [74]. Copyright 2019, WILEY–VCH

Fig. 7

Reproduced with permission from Ref. [77]. Copyright 2021, American Chemical Society

Fig. 8

Reproduced with permission from Ref. [80]. Copyright 2021, Elsevier Ltd

Fig. 9

Reproduced with permission from Ref. [86]. Copyright 2021, American Chemical Society

Fig. 10

Reproduced with permission from Ref. [87]. Copyright 2022, American Chemical Society

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Acknowledgements

This study was financially supported by the National Natural Science Foundation of China (Nos. 22105116, 51872030, 51631001, 51702016, 51902023 and 21801015), Joint R&D Plan of Hongkong, Macao, Taiwan and Beijing (No. Z191100001619002), the Fundamental Research Funds for the Central Universities (No. 2017CX01003) and Beijing Institute of Technology Research Fund Program for Young Scholars.

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  1. Institute of Medical-Industrial Integration, Beijing Key Laboratory of Structurally Controllable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China

    Dong Wang

  2. Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China

    Jia-Tao Zhang

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Jia-Tao Zhang is an editorial board member for Rare Metals and was not involved in the editorial review or the decision to publish this article. The authors declare that they have no conflict of interests.

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Wang, D., Zhang, JT. Metal-based inorganic nanocrystals for biological sonodynamic therapy applications: recent progress and perspectives. Rare Met. 43, 413–430 (2024). https://doi.org/10.1007/s12598-023-02450-6

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