Avoid common mistakes on your manuscript.
Case
An 82-year-old woman presented with exertional dyspnea that developed following a persistent low-grade fever of 37.5 °C for 10 days. She had been diagnosed with Mycobacterium avium pulmonary infection 24 years earlier and had intermittently received the standard antibiotics combination therapy. On admission, blood test results showed mildly elevated tumor markers with CEA and CA 125 of 5.2 ng/mL (ref: 0–5.0 ng/mL) and 39 U/mL, (ref: 0–35.0 U/mL) respectively. and elevated d-dimer of 5.04 μg/ml. An electrocardiogram confirmed atrial fibrillation (AF) with an average heart rate of 121/min, which had not been observed during a routine examination 2 months earlier. Chest radiographs showed abnormal opacity and decreased air volume, mainly in the superior left lung field, where computed tomography also showed destruction of the structures of the left superior lobe of the lung (Fig. 1a, b).
Transthoracic echocardiography (TTE) showed a left ventricular ejection fraction of 60%, normal left ventricular wall motion, and no significant left heart valvular dysfunction. Additionally, TTE also showed dilation of the left atrium (LA; volume index, 35.5 mL/m2) and a mobile mass-like structure within the LA, whereas no obvious structures were found within the left atrial appendage (LAA). To observe the structure in more detail, we performed observation from a higher intercostal space. The structure appeared to be protruding from the left superior pulmonary vein (LSPV) into the LA (Fig. 1c, d, Movie 1). It was still difficult to identify the site of attachment, and thrombus, myxoma, and metastatic tumor were considered as differential diagnoses.
At this time, she was started on treatment with apixaban and bisoprolol for tachycardic AF (CHA2DS2-VASc score 2). On day 19, TEE showed that the mass attached to the LA wall near the LSPV orifice (Fig. 1e). On 3D-TEE, the structure was observed to be club-shaped from the LSPV to the LA (Fig. 1f, Movie 2, 3). The mass eventually shrank and disappeared with anticoagulation by day 99, and we finally diagnosed it as thrombus (Movie 4).
Discussion
AF is the most common arrhythmia associated with stroke and embolism, and intra-atrial thrombi occurring in the LAA are the most frequently reported [1, 2]. Normal pulmonary venous blood flows continuously enter the LA, but in this case, in addition to AF tachycardia, tissue destruction in the left upper lobe reduced the return blood flow from the LSPV, causing a period of intermittent cessation of blood flow (Fig. 1g, h). As a result, the blood flow from the LSPV did not merge with the other three pulmonary venous blood flows in the LA and stagnated near the LA orifice of the LSPV, which may have led to thrombus formation outside the LAA. Pulmonary vein thrombosis is associated with early postoperative lobectomy, lung transplantation, and malignancy [3, 4], and thrombus formation at the LSPV stump after left upper lobectomy appears to have a similar pathogenesis [5].
Conclusion
This report described a rare case in which a thrombus is attached to the orifice of the LSPV, suggesting the importance of recognizing intra-atrial thrombus formation outside the LAA on TTE and TEE.
Abbreviations
- PT:
-
Prothrombin time
- AF:
-
Atrial fibrillation
- TTE:
-
Transthoracic echocardiography
- LA:
-
Left atrium
- LAA:
-
Left atrial appendage
- LSPV:
-
Left superior pulmonary vein
- TEE:
-
Transesophageal echocardiogram
References
Watoson T, Shantsila E, Lip GY. Mechanisms of thrombogenesis in atrial fibrillation: Virchow’s triad revisited. Lancet. 2009;373:155–66.
Thambidorai SK, Murray RD, Parakh K, et al. Utility of transesophageal echocardiography in identification of thrombogenic milieu in patients with atrial fibrillation (an ACUTE ancillary study). Am J Cardiol. 2005;96:935–41.
Chaaya G, Vishnubhotla P. Pulmonary vein thrombosis: a recent systematic review. Cureus. 2017;9:e993.
Nam H, Roldan CA, Shively BK. Pulmonary vein thrombosis. Chest. 1993;104:624–6.
Matsumoto M, Takegahara K, Inoue T, et al. 4D flow MR imaging reveals a decrease of left atrial blood flow in a patient with cardioembolic cerebral infarction after pulmonary left upper lobectomy. Magn Reson Med Sci. 2020;19:290–3.
Funding
Open Access funding provided by Saitama Medical University.
Author information
Authors and Affiliations
Contributions
Conceptualization: KN, YS and KY; Analysis and investigation: KN, YS and YN; Writing-original draft preparation: KN; Writing-review and editing: YS, TM, YN, Shiro Iwanaga and KY; Supervision: YN, SI, TM and KY.
Corresponding author
Ethics declarations
Conflict of interest
Kazuhiro Nomura, Yuna Shinohara, Yoshie Nakajima, Shiro Iwanaga, Takuya Maeda and Keiji Yamamoto declare that they have no conflict of interest.
Human rights statements and informed consent
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from the patient included in the report.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Supplementary file1 Movie 1 Transthoracic echocardiography shows a mobile mass (32 × 12 mm) protruding from the left superior pulmonary vein to the left atrium (MP4 1628 KB)
Supplementary file2 Movie 2 3D-transesophageal echocardiogram showed that the thrombus adhered to a site distinctly different from the left atrial appendage, and was observed to be club-shaped from the left superior pulmonary vein to the left atrium. MV, mitral valve; AV, aortic valve; Ao, aorta (MP4 30502 KB)
Supplementary file3 Movie 3 3D-transesophageal echocardiogram showed that the thrombus adhered to a site distinctly different from the left atrial appendage, and was observed to be club-shaped from the left superior pulmonary vein to the left atrium. MV, mitral valve; AV, aortic valve; Ao, aorta (MP4 33130 KB)
Supplementary file4 Movie 4 Transthoracic echocardiography showed that the thrombus tended to regress with anticoagulation (MP4 101901 KB)
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Nomura, K., Shinohara, Y., Nakajima, Y. et al. Left atrial thrombus attached to the orifice of the left superior pulmonary vein: a case report. J Echocardiogr (2024). https://doi.org/10.1007/s12574-024-00644-0
Received:
Revised:
Accepted:
Published:
DOI: https://doi.org/10.1007/s12574-024-00644-0