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Pharmacokinetics and depletion of florfenicol in striped catfish Pangasianodon hypophthalmus after oral administration

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  • Aquaculture
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Abstract

Florfenicol is commonly used to treat bacterial diseases in striped catfish Pangasianodon hypophthalmus aquaculture with limited knowledge of pharmacokinetic database, explaining treatment failures experienced by farmers. Striped catfish (100 g) were fed medicated feed (10 mg florfenicol/kg fish) by oral gavage. Plasma, liver, and kidney were collected up to 96.0 h after drug administration and analyzed for florfenicol. A single oral gavage dose of 10 mg florfenicol/kg fish revealed a rapid elimination, demonstrated by an elimination half-life (T1/2el) of 2.56 h. Florfenicol amine was found in liver and kidney tissue. The calculation of T > MIC (time that the concentration remains above the minimum inhibitory concentration) revealed a potential therapeutic effect on bacillary necrosis, a common disease in striped catfish if the dosing interval is 12 h. The depletion of florfenicol in striped catfish muscle was determined in feeding trials with medicated feed containing florfenicol at 10 mg/kg fish for five consecutive days in tank and pond conditions. The fast elimination of florfenicol resulted in a withdrawal time of two days (or 39 degree days) in proposed tank-rearing conditions and four days (or 112 degree days) in pond-rearing conditions.

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Acknowledgements

We would like to thank Mr. Nguyen Cong Luan for his contribution to the experiment setting up and sampling in this study. This study was funded in part by the Can Tho University Improvement Project VN14-P6, supported by a Japanese Overseas Development Agency loan.

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Authors and Affiliations

  1. College of Aquaculture and Fisheries, Can Tho University, 3/2 Street, Campus II, Can Tho, Vietnam

    Quang Vinh Pham, Quoc Thinh Nguyen, Thi Hoang Oanh Dang & Minh Phu Tran

  2. Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, 9820, Merelbeke, Belgium

    Mathias Devreese & Siska Croubels

  3. Faculty of Health and Medical Sciences, University of Copenhagen, Stigböjlen 4, 1870, Frederiksberg C, Denmark

    Anders Dalsgaard

  4. Laboratory of Fish Health Management, Tokyo University of Marine Science and Technology, Minato, Tokyo, 108-8477, Japan

    Masashi Maita

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  1. Quang Vinh Pham
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  2. Quoc Thinh Nguyen
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  3. Mathias Devreese
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  4. Siska Croubels
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  5. Thi Hoang Oanh Dang
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  6. Anders Dalsgaard
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  8. Minh Phu Tran
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Correspondence to Minh Phu Tran.

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All experiments were carried out in accordance with national guidelines on the protection and experimental animal welfare in Vietnam (Law of Animal Health 2015).

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Pham, Q.V., Nguyen, Q.T., Devreese, M. et al. Pharmacokinetics and depletion of florfenicol in striped catfish Pangasianodon hypophthalmus after oral administration. Fish Sci 89, 357–365 (2023). https://doi.org/10.1007/s12562-023-01682-w

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  • DOI: https://doi.org/10.1007/s12562-023-01682-w

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